Results 21 to 30 of about 33,694 (246)

Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models

Acta Neuropathologica Communications, 2022
Complement is involved in developmental synaptic pruning and pathological synapse loss in Alzheimer’s disease. It is posited that C1 binding initiates complement activation on synapses; C3 fragments then tag them for microglial phagocytosis. However, the
Sarah M. Carpanini, Megan Torvell, Ryan J. Bevan, Robert A. J. Byrne, Nikoleta Daskoulidou, Takashi Saito, Takaomi C. Saido, Philip R. Taylor, Timothy R. Hughes, Wioleta M. Zelek, B. Paul Morgan   +10 more
doaj   +1 more source

Pseudomonas aeruginosa and the Complement System: A Review of the Evasion Strategies

Microorganisms, 2023
The increasing emergence of multidrug resistant isolates of P. aeruginosa causes major problems in hospitals worldwide. This concern is particularly significant in bloodstream infections that progress rapidly, with a high number of deaths within the ...
Alex González-Alsina, Margalida Mateu-Borrás, Antonio Doménech-Sánchez, Sebastián Albertí   +3 more
doaj   +1 more source

Integration of a virus membrane protein into the lipid bilayer of target cells as a prerequisite for immune cytolysis [PDF]

, 1979
Structural requirements for membrane antigens on target cells to mediate immune cytolysis were studied in a model system with purified membrane proteins from Semliki Forest virus (SFV). These SFV spike proteins were isolated in the form of detergent- and
Schirrmacher, V., B Morein, V Schirrmacher, Koszinowski, Ulrich H., Morein, B., D Barz, Barz, D., U Koszinowski   +7 more
core   +1 more source

Internalization of the Membrane Attack Complex Triggers NLRP3 Inflammasome Activation and IL-1β Secretion in Human Macrophages

Frontiers in Immunology, 2021
Interleukin 1β (IL-1β) plays a major role in inflammation and is secreted by immune cells, such as macrophages, upon recognition of danger signals. Its secretion is regulated by the inflammasome, the assembly of which results in caspase 1 activation ...
Ines Diaz-del-Olmo, Jonathan Worboys, Fatima Martin-Sanchez, Anna Gritsenko, Ashley R. Ambrose, Gillian M. Tannahill, Eva-Maria Nichols, Gloria Lopez-Castejon, Daniel M. Davis   +8 more
doaj   +1 more source

Complement and platelets: prothrombotic cell activation requires membrane attack complex–induced release of danger signals [PDF]

, 2023
Complement activation in the diseases paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) results in cytolysis and fatal thrombotic events, which are largely refractory to anticoagulation and/or antiplatelet therapy ...
Mannes, Marco,, Wohlgemuth, Lisa,, Nilsson Ekdahl, Kristina,, Marco Mannes, Oskar Eriksson, Bo Nilsson, Markus Huber-Lang, Hoenig, Manfred,, Jacobsen, Eva -Maria, Hafner, Susanne,, Jacobsen, Eva -Maria,, Nilsson Ekdahl, Kristina, Susanne Hafner, David Alexander Christian Messerer, Manivel, Vivek Anand, Lisa Wohlgemuth, Schrezenmeier, Hubert, Hubert Schrezenmeier, Arthur Dopler, Kristina N. Ekdahl, Christian K. Braun, Messerer, David Alexander Christian,, Nilsson, Bo, Mannes, Marco, Manfred Hoenig, Christoph Q. Schmidt, Dopler, Arthur,, Pechtl, Veronika, Messerer, David Alexander Christian, Braun, Christian K., Braun, Christian K.,, Schrezenmeier, Hubert,, Dopler, Arthur, Nilsson, Bo,, Eva-Maria Jacobsen, Eriksson, Oskar,, Hoenig, Manfred, Pechtl, Veronika,, Vivek Anand Manivel, Manivel, Vivek Anand,, Schmidt, Christoph Q., Schmidt, Christoph Q.,, Wohlgemuth, Lisa, Veronika Pechtl, Hafner, Susanne, Huber-Lang, Markus, Eriksson, Oskar, Huber-Lang, Markus,   +47 more
core   +2 more sources

Intravitreal Therapy Against the Complement Factor C5 Prevents Retinal Degeneration in an Experimental Autoimmune Glaucoma Model

Frontiers in Pharmacology, 2019
In glaucoma, studies revealed an involvement of the complement system. In an experimental autoimmune glaucoma model, immunization with an optic nerve homogenate antigen (ONA) led to retinal ganglion cell (RGC) loss, while intraocular pressure (IOP ...
Sabrina Reinehr, Sara C. Gomes, Caroline J. Gassel, M. Ali Asaad, Gesa Stute, Marc Schargus, Marc Schargus, H. Burkhard Dick, Stephanie C. Joachim   +8 more
doaj   +1 more source

Microvesicles in disease [PDF]

, 2014
On activation cells shed vesicles from their surface by the process of ectocytosis. These micro-vesicles or Ectosomes express phosphatidyl-serine (PS) on their surface, which can elicit a range of biological effects from immune-suppression to the ...
Čumpelik, Arun
core   +1 more source

Ravulizumab in Myasthenia Gravis: A Review of the Current Evidence

Neuropsychiatric Disease and Treatment, 2023
Tuan Vu,1 Heinz Wiendl,2 Masahisa Katsuno,3 Stephen W Reddel,4 James F Howard Jr5 1Department of Neurology, University of South Florida Morsani College of Medicine, Tampa, FL, USA; 2Department of Neurology with Institute of Translational Neurology ...
Vu T, Wiendl H, Katsuno M, Reddel SW, Howard JF Jr   +4 more
doaj  

Complement activation in human prion disease

Neurobiology of Disease, 2004
The central event in the neuropathological process of prion diseases (PrD) is the accumulation of abnormal prion protein accompanied by severe neuronal loss.
Gabor G Kovacs, Philippe Gasque, Thomas Ströbel, Elisabeth Lindeck-Pozza, Michaela Strohschneider, James W Ironside, Herbert Budka, Marin Guentchev   +7 more
doaj   +1 more source

Structural basis for membrane attack complex inhibition by CD59 [PDF]

, 2023
CD59 is an abundant immuno-regulatory receptor that protects human cells from damage during complement activation. Here we show how the receptor binds complement proteins C8 and C9 at the membrane to prevent insertion and polymerization of membrane ...
Voisin, Tomas, Tate, Edward, Gardner, Scott, Tate, Edward W., Couves, Emma, Bickel, Jasmine, Tate, Edward W, Voisin, Tomas B., Bubeck, Doryen, Bickel, Jasmine K., Couves, Emma C, Stansfeld, Phillip J, Stansfeld, Phillip J., Couves, Emma C., Voisin, Tomas B, Bickel, Jasmine K, Stansfeld, Phillip   +16 more
core   +1 more source