Results 21 to 30 of about 93,626 (282)

Structural basis of soluble membrane attack complex packaging for clearance

Nature Communications, 2021
To prevent unregulated complement activation, extracellular chaperones capture soluble precursors to the membrane attack complex (sMAC). Here, structural analysis of sMAC reveals how clusterin recognizes heterogeneous sMAC complexes and inhibits ...
Anaïs Menny, Marie V. Lukassen, Emma C. Couves, Vojtech Franc, Albert J. R. Heck, Doryen Bubeck   +5 more
doaj   +1 more source

Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex

Journal of Innate Immunity, 2022
Damage and disease of nerves activates the complement system. We demonstrated that activation of the terminal pathway of the complement system leads to the formation of the membrane attack complex (MAC) and delays regeneration in the peripheral nervous ...
Heidi Gytz Olesen, Iliana Michailidou, Wioleta M. Zelek, Jeroen Vreijling, Patrick Ruizendaal, Ferry de Klein, J. Arnoud Marquart, Thomas B. Kuipers, Hailiang Mei, Yuchun Zhang, Muhammad Ahasan, Krista K. Johnson, Yi Wang, B. Paul Morgan, Marcus van Dijk, Kees Fluiter, Gregers Rom Andersen, Frank Baas   +17 more
doaj   +1 more source

A Case of Neisseria sicca Bacteremia Due to Eculizumab Therapy

Annals of Internal Medicine: Clinical Cases, 2023
Eculizumab is a monoclonal antibody indicated for the treatment of complement-mediated disorders. Despite its utility, eculizumab increases risk for infection with Neisseria species, owing to membrane attack complex inhibition.
Kelly A. Russo, Ted Louie
doaj   +1 more source

Complement System Part I – Molecular Mechanisms of Activation and Regulation [PDF]

, 2015
Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger ...
Lubka T. Roumenina, Nicolas S. Merle, Sarah Elizabeth Church, Veronique Fremeaux-Bacchi   +3 more
core   +8 more sources

Astrocyte- and Neuron-Derived Extracellular Vesicles from Alzheimer’s Disease Patients Effect Complement-Mediated Neurotoxicity

Cells, 2020
We have previously shown that blood astrocytic-origin extracellular vesicles (AEVs) from Alzheimer’s disease (AD) patients contain high complement levels.
Carlos J. Nogueras-Ortiz, Vasiliki Mahairaki, Francheska Delgado-Peraza, Debamitra Das, Konstantinos Avgerinos, Erden Eren, Matthew Hentschel, Edward J. Goetzl, Mark P. Mattson, Dimitrios Kapogiannis   +9 more
doaj   +1 more source

Trichinella spiralis paramyosin binds to C8 and C9 and protects the tissue-dwelling nematode from being attacked by host complement. [PDF]

PLoS Neglected Tropical Diseases, 2011
BACKGROUND: Paramyosin is a thick myofibrillar protein found exclusively in invertebrates. Evidence suggested that paramyosin from helminths serves not only as a structural protein but also as an immunomodulatory agent.
Zhifei Zhang, Jing Yang, Junfei Wei, Yaping Yang, Xiaoqin Chen, Xi Zhao, Yuan Gu, Shijuan Cui, Xinping Zhu   +8 more
doaj   +1 more source

Clinical Isolates of Acinetobacter spp. Are Highly Serum Resistant Despite Efficient Recognition by the Complement System

Frontiers in Immunology, 2022
Gram-negative bacteria from the genus Acinetobacter are responsible for life-threating hospital-related infections such as pneumonia, septicemia, and meningitis, especially in immunocompromised patients.
Michal Magda, Serena Bettoni, Maisem Laabei, Derek Fairley, Thomas A. Russo, Kristian Riesbeck, Anna M. Blom   +6 more
doaj   +1 more source

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]

, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
A Alitalo, A Alitalo, A Alitalo, A Seling, AC Steere, AM Blom, Andreas Klos, AP van Dam, B Stevenson, C Hammerschmidt, C Siegel, C Siegel, Christine Skerka, Claudia Hammerschmidt, CS Brooks, Dania Richter, E Diza, F Strle, Franz-Rainer Matuschka, H Jiang, H Michel, J Hellwage, J Pietikainen, J Potempa, Jasmin Schwab, JD Lambris, JV McDowell, K Hartmann, K Haupt, K Kurtenbach, K Kurtenbach, K Saito, K Whaley, KM Hovis, KP Hunfeld, L Beinrohr, M Collares-Pereira, M Jusko, M Józsi, MJ Walport, MK Pangburn, MR Bhide, MR Bhide, MR Kenedy, MS Metts, N Marr, ND van Burgel, P Herzberger, P Herzberger, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Ramu, Peter F. Zipfel, Peter Kraiczy, PF Zipfel, PF Zipfel, R Dieterich, R Wallich, Reinhard Wallich, RG Discipio, RJ Ziccardi, S Breitner-Ruddock, S Grosskinsky, S Grosskinsky, S Heinen, S Kühn, SC Bock, SG Rijpkema, SH Rooijakkers, T Fujita, T Fujita, V Brade, Y Terao   +76 more
core   +17 more sources

Hijacking Factor H for Complement Immune Evasion

Frontiers in Immunology, 2021
The complement system is an essential player in innate and adaptive immunity. It consists of three pathways (alternative, classical, and lectin) that initiate either spontaneously (alternative) or in response to danger (all pathways). Complement leads to
Sara R. Moore, Smrithi S. Menon, Claudio Cortes, Viviana P. Ferreira   +3 more
doaj   +1 more source

Complement system activation contributes to the ependymal damage induced by microbial neuraminidase [PDF]

, 2016
Background In the rat brain, a single intracerebroventricular injection of neuraminidase from Clostridium perfringens induces ependymal detachment and death.
A Ascherio, A Vakeva, AH Stephan, AJ Jimenez, B. Paul Morgan, BH Heijnen, BK Rima, BP Morgan, BP Morgan, C Canova, C Casarsa, C Costa, CA Molgaard, D Bhole, D Orth, D Ricklin, DA Lim, DP Schafer, EM Rodriguez, ER Podack, F Doetsch, FH Brennan, G Margolis, H Ninomiya, HJ Muller-Eberhard, IL Graves, J Finsterer, J Li, J Schneider-Schaulies, JE Bruni, Jesús M. Grondona, JJ Alexander, JM Grondona, JM Grondona, JM Grondona, JP Melis, Krista Johnson, L Petit, M Takahashi, María Dolores López-Ávalos, MB Marques, MC Gomez-Roldan, MD Kazatchkine, MG Dixhoorn van, MK Pangburn, MK Pangburn, MK Pangburn, N Donin, N Rawal, OB Spiller, P Gasque, P Granados-Duran, P Paez, Pablo Granados-Durán, Paul P. Tamburini, Pedro Fernández-Llebrez, PF Stahel, PF Stahel, PK Lauf, PL Leenaerts, Q Shi, R Kornfeld, RA Marrie, RG Medicus, RJ Mead, RM Peckham, RP Rother, RT Johnson, RT Johnson, S Kuchler, S Meri, SA Rollins, SA Rollins, SB Laursen, SH Fatemi, SM Lucas, SR Barnum, T Ebert, T Fujita, T Takano, Timothy R. Hughes, V Coskun, V Ramaglia, WA Tompkins, WS Carbonell   +84 more
core   +2 more sources