Results 11 to 20 of about 93,626 (282)

PRELP protein inhibits the formation of the complement membrane attack complex. [PDF]

J Biol Chem, 2012
Background: PRELP binds the complement inhibitor C4b-binding protein and may have other complement regulatory functions. Results: PRELP inhibits the formation of the membrane attack complex and thereby inhibits all three pathways of complement ...
Happonen KE, Fürst CM, Saxne T, Heinegård D, Blom AM.   +4 more
europepmc   +3 more sources

Interference of the Zika Virus E-Protein With the Membrane Attack Complex of the Complement System

Frontiers in Immunology, 2020
The complement system has developed different strategies to clear infections by several effector mechanisms, such as opsonization, which supports phagocytosis, attracting immune cells by C3 and C5 cleavage products, or direct killing of pathogens by the ...
Zahra Malekshahi, Britta Schiela, Sarah Bernklau, Zoltan Banki, Reinhard Würzner, Heribert Stoiber   +5 more
doaj   +2 more sources

Bacterial killing by complement requires membrane attack complex formation via surface‐bound C5 convertases

EMBO Journal, 2019
The immune system kills bacteria by the formation of lytic membrane attack complexes (MACs), triggered when complement enzymes cleave C5. At present, it is not understood how the MAC perturbs the composite cell envelope of Gram‐negative bacteria.
D. Heesterbeek, B. Bardoel, Edward S. Parsons, Isabel Bennett, M. Ruyken, Dennis J. Doorduijn, Ronald D. Gorham, Evelien T. M. Berends, Alice L. B. Pyne, B. Hoogenboom, S. Rooijakkers   +10 more
semanticscholar   +3 more sources

CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells

Journal of Experimental Medicine, 1989
A novel cell surface antigen has been identified on a wide range of lymphoid cells and erythrocytes. A mAb YTH 53.1 (CD59) against this antigen enhanced the lysis of human red cells and lymphocytes by homologous complement.
Alexandra, Davies, L. David, Simmons, Geoff, Hale, A. Richard, Harrison, Helen, Tighe, Peterj, Lachmann, Herman Waldmanns   +12 more
semanticscholar   +3 more sources

Selective accumulation of the complement membrane attack complex in aging choriocapillaris. [PDF]

Exp Eye Res, 2016
Chirco KR, Tucker BA, Stone EM, Mullins RF.   +3 more
europepmc   +2 more sources

Active Human Complement Reduces the Zika Virus Load via Formation of the Membrane-Attack Complex

Frontiers in Immunology, 2018
Although neglected in the past, the interest on Zika virus (ZIKV) raised dramatically in the last several years. The rapid spread of the virus in Latin America and the association of the infection with microcephaly in newborns or Guillain-Barré Syndrome ...
Britta Schiela, Sarah Bernklau, Zahra Malekshahi, Daniela Deutschmann, Iris Koske, Zoltan Banki, Nicole M. Thielens, Reinhard Würzner, Cornelia Speth, Guenter Weiss, Karin Stiasny, Eike Steinmann, Heribert Stoiber   +12 more
doaj   +2 more sources

Soluble MAC is primarily released from MAC-resistant bacteria that potently convert complement component C5

eLife, 2022
The membrane attack complex (MAC or C5b-9) is an important effector of the immune system to kill invading microbes. MAC formation is initiated when complement enzymes on the bacterial surface convert complement component C5 into C5b.
Dennis J Doorduijn, Marie V Lukassen, Marije FL van 't Wout, Vojtech Franc, Maartje Ruyken, Bart W Bardoel, Albert JR Heck, Suzan HM Rooijakkers   +7 more
doaj   +1 more source

Complement Regulator CD59 Protects Against Atherosclerosis by Restricting the Formation of Complement Membrane Attack Complex

Circulation Research, 2009
Gongxiong Wu, Weiguo Hu, A. Shahsafaei, Wenping Song, Martín Dobarro, G. Sukhova, R. Bronson, G. Shi, R. Rother, J. Halperin, X. Qin   +10 more
semanticscholar   +3 more sources

Complement and platelets: prothrombotic cell activation requires membrane attack complex–induced release of danger signals

Blood Advances, 2023
Key Points • Proximal and terminal complement activation products fail to directly induce prothrombotic platelet activation.• MAC-mediated release of intracellular ADP is sufficient and necessary for complement-mediated platelet activation.
Marco Mannes, Veronika Pechtl, S. Hafner, Arthur Dopler, O. Eriksson, V. Manivel, Lisa Wohlgemuth, D. Messerer, H. Schrezenmeier, K. Ekdahl, B. Nilsson, Eva Jacobsen, Manfred Hoenig, M. Huber-Lang, C. Braun, C. Schmidt   +15 more
semanticscholar   +1 more source

Complement-dependent cytotoxicity of human autoantibodies against myelin oligodendrocyte glycoprotein

Frontiers in Neuroscience, 2023
BackgroundThe autoantibody to myelin oligodendrocyte glycoprotein (MOG), a component of the central nervous system myelin, has been identified in a subset of demyelinating diseases.
Kuniko Kohyama, Hiroya Nishida, Kimihiko Kaneko, Tatsuro Misu, Ichiro Nakashima, Hiroshi Sakuma   +5 more
doaj   +1 more source