Results 11 to 20 of about 33,694 (246)

The membrane attack complex as an indicator of complement hyperactivation in type 2 diabetes mellitus

Сахарный диабет, 2011
Aim. Comparative analysis of the levels of the membrane attack complex (MAC) - an end product of complement activation, and of hemolytic activitiesof C1 and C3 complement components in sera of patients with diabetes mellitus 2 (DM2) and healthy subjects.
Elina Alexandrovna Arakelova, Meri Robertovna Ovsepyan, Anna Surenovna Boyadzhyan, Arsen Artashesovich Arakelyan, Astkhik Artavazdovna Gevorkyan, Ashot Andreevich Mamikonyan   +5 more
doaj   +3 more sources

PRELP protein inhibits the formation of the complement membrane attack complex. [PDF]

J Biol Chem, 2012
PRELP is a 58-kDa proteoglycan found in a variety of extracellular matrices, including cartilage and at several basement membranes. In rheumatoid arthritis (RA), the cartilage tissue is destroyed and fragmented molecules, including PRELP, are released ...
Happonen KE, Fürst CM, Saxne T, Heinegård D, Blom AM.   +4 more
europepmc   +4 more sources

Astrocyte- and Neuron-Derived Extracellular Vesicles from Alzheimer’s Disease Patients Effect Complement-Mediated Neurotoxicity

Cells, 2020
We have previously shown that blood astrocytic-origin extracellular vesicles (AEVs) from Alzheimer’s disease (AD) patients contain high complement levels.
Carlos J. Nogueras-Ortiz, Vasiliki Mahairaki, Francheska Delgado-Peraza, Debamitra Das, Konstantinos Avgerinos, Erden Eren, Matthew Hentschel, Edward J. Goetzl, Mark P. Mattson, Dimitrios Kapogiannis   +9 more
doaj   +1 more source

A Case of Neisseria sicca Bacteremia Due to Eculizumab Therapy

Annals of Internal Medicine: Clinical Cases, 2023
Eculizumab is a monoclonal antibody indicated for the treatment of complement-mediated disorders. Despite its utility, eculizumab increases risk for infection with Neisseria species, owing to membrane attack complex inhibition.
Kelly A. Russo, Ted Louie
doaj   +1 more source

Trichinella spiralis paramyosin binds to C8 and C9 and protects the tissue-dwelling nematode from being attacked by host complement. [PDF]

PLoS Neglected Tropical Diseases, 2011
BACKGROUND: Paramyosin is a thick myofibrillar protein found exclusively in invertebrates. Evidence suggested that paramyosin from helminths serves not only as a structural protein but also as an immunomodulatory agent.
Zhifei Zhang, Jing Yang, Junfei Wei, Yaping Yang, Xiaoqin Chen, Xi Zhao, Yuan Gu, Shijuan Cui, Xinping Zhu   +8 more
doaj   +1 more source

Clinical Isolates of Acinetobacter spp. Are Highly Serum Resistant Despite Efficient Recognition by the Complement System

Frontiers in Immunology, 2022
Gram-negative bacteria from the genus Acinetobacter are responsible for life-threating hospital-related infections such as pneumonia, septicemia, and meningitis, especially in immunocompromised patients.
Michal Magda, Serena Bettoni, Maisem Laabei, Derek Fairley, Thomas A. Russo, Kristian Riesbeck, Anna M. Blom   +6 more
doaj   +1 more source

Hijacking Factor H for Complement Immune Evasion

Frontiers in Immunology, 2021
The complement system is an essential player in innate and adaptive immunity. It consists of three pathways (alternative, classical, and lectin) that initiate either spontaneously (alternative) or in response to danger (all pathways). Complement leads to
Sara R. Moore, Smrithi S. Menon, Claudio Cortes, Viviana P. Ferreira   +3 more
doaj   +1 more source

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]

, 2015
The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Dimitrios Stampoulis, M. Francesca Cordeiro, Williams, JA, Jennifer A. E. Williams, Stampoulis, D, Li Guo, Shi, H, Guo, L, Moss, SE, Francesca Cordeiro, M, Stephen E. Moss, Hui Shi   +11 more
core   +1 more source

Neuropathophysiological potential of Guillain-Barré syndrome anti-ganglioside-complex antibodies at mouse motor nerve terminals [PDF]

, 2011
Objectives:  Anti-ganglioside antibodies are present in approximately half of Guillain–Barré syndrome (GBS) patients. Recently, it has been shown that a considerable proportion of these patients has serum antibodies against antigenic epitopes formed by a
Susumu Kusunoki, Tio-Gillen, Anne P., Plomp, J.J., Kusunoki, Susumu, Tio-Gillen, A.P., Willison, H.J., Broos, Ludo A.M., Ueda, M., Mark L. Kuijf, Ludo A. M. Broos, Kuijf, Mark L., Jacobs, B.C., Greenshields, Kay N., Jacobs, Bart C., Zitman, F.M.P., Hugh J. Willison, Anne P. Tio-Gillen, Masami Ueda, Kuijf, M.L., Jaap J. Plomp, Kusunoki, S., Greenshields, K.N., Plomp, Jaap J., Femke M. P. Zitman, Broos, L.A.M., Kay N. Greenshields, Ken-ichi Kaida, Willison, Hugh J., Bart C. Jacobs, Kaida, Ken Ichi, Kaida, K.I., Ueda, Masami, Zitman, Femke M.P.   +32 more
core   +1 more source

Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59

Cell Reports, 2013
Pore-forming proteins containing the structurally conserved membrane attack complex/perforin fold play an important role in immunity and host-pathogen interactions.
Steven Johnson, Nicholas J. Brooks, Richard A.G. Smith, Susan M. Lea, Doryen Bubeck   +4 more
doaj   +1 more source