Results 41 to 50 of about 651,857 (304)

Activation of human complement system by dextran-coated iron oxide nanoparticles is not affected by dextran/Fe ratio, hydroxyl modifications and crosslinking

Frontiers in Immunology, 2016
While having tremendous potential as therapeutic and imaging tools, the clinical use of engineered nanoparticles has been associated with serious safety concerns. Activation of the complement cascade and release of proinflammatory factors C3a and C5a may
Guankui Wang, Fangfang Chen, Nirmal Banda, VM Holers, Linping Wu, Moein Moghimi, Dmitri Simberg   +6 more
doaj   +1 more source

Complement C3 variant and the risk of age-related macular degeneration [PDF]

, 2007
Background: Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors.
Armbrecht, AM, Bird, AC, Clayton, DG, Deary, IJ, Dhillon, B, Genetic Factors AMD Study G, Hayward, C, Khan, JC, Matharu, BK, Moore, AT, Morgan, J, Redmond, E, Sepp, T, Shahid, H, Thurlby, DA, Wright, AF, Yates, JRW   +16 more
core   +1 more source

Nanoporesize affects complement activation

Journal of Biomedical Materials Research Part A, 2008
AbstractIn the present study, we have shown the vast importance of biomaterial nanotexture when evaluating inflammatory response. For the first time in an in vitro whole blood system, we have proven that a small increase in nanoporesize, specifically 180 nm (from 20 to 200 nm), has a huge effect on the complement system.
Ferraz, Natalia, Nilsson, Bo, Hong, Jaan, Karlsson Ott, Marjam   +3 more
openaire   +4 more sources

Variation in innate immunity in relation to ectoparasite load, age and season : a field experiment in great tits (Parus major) [PDF]

, 2010
It remains largely unknown which factors affect the innate immune responses of free-living birds. Nevertheless, the degree of innate immunity may play a crucial role in an individual's survival as it procures the first defence against pathogens.
Apanius, Ardia, Ardia, Bandeira, Baumgarth, Bayyari, Bentley, Boes, Buechler, Buehler, Buehler, Christe, de Lope, Duffy, Greives, Grindstaff, Harper, Hasselquist, Hasselquist, Heeb, Huber, Ilmonen, Janeway, Kenward, Ketterson, Kilpimaa, Klasing, Klasing, Lee, Lee, Lindström, Lochmiller, Martin, Matson, Mauck, Mendes, Morales, Moreno, Moreno, Mougeot, Møller, Møller, Nilsson, Norris, Ochsenbein, Pacejka, Palacios, Parejo, Parejo, Pihlaja, Pomeroy, Reid, Richner, Ricklefs, Råberg, Sheldon, Star, Stier, Svensson, Thomson, Thornton, Tschirren, Whiteman, Wingfield, Zuk, Zuk   +65 more
core   +1 more source

Feasibility and Preliminary Efficacy of Integrative Neuromuscular Training for Childhood Cancer Survivors: A Pilot Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of childhood acute lymphoblastic leukemia (ALL) often exhibit early deficits in muscle and movement competence, which can compromise long‐term health. Integrative neuromuscular training (INT), a multifaceted approach combining fundamental movement activities with strength exercises, may help address these deficits during ...
Anna Maria Markarian, Robert U. Newton, Dennis R. Taaffe, Nicholas G. Gottardo, Santosh Valvi, Carolyn J. Peddle‐McIntyre, Jodie Cochrane Wilkie, Daniel A. Galvão   +7 more
wiley   +1 more source

C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy [PDF]

, 2016
Introduction Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options.
Barrie, Jennifer A., Cunningham, Madeleine E., Fewou, Simon N., Furukawa, Koichi, McGonigal, Rhona, Sankaranarayanan, Sethu, Willison, Hugh J., Yao, Denggao, Yednock, Ted A.   +8 more
core   +2 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

NETosing neutrophils activate complement both on their own NETs and bacteria via alternative and non-alternative pathways

Frontiers in Immunology, 2016
Neutrophils deposit antimicrobial proteins such as myeloperoxidase and proteases on chromatin, which they release as neutrophil extracellular traps (NETs). Neutrophils also carry key components of the complement alternative pathway (AP) such as properdin
Joshua eYuen, Fred G. Pluthero, David N. Douda, Magdalena eRiedl, Ahmed eCherry, Marina eUlanova, Walter H.A. Kahr, Walter H.A. Kahr, Nades ePalaniyar, Christoph eLicht, Christoph eLicht   +10 more
doaj   +1 more source

The differential ability of human IgG1 and IgG4 to activate complement is determined by the COOH-terminal sequence of the CH2 domain. [PDF]

, 1991
Using domain switch chimeric antibodies, we confirm the important role of CH2 in complement activation. In addition, we demonstrate that the structures responsible for the differential ability of human IgG1 and IgG4 to activate complement are located at ...
Canfield, SM, Morrison, SL, Tao, MH
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source