Results 61 to 70 of about 651,857 (304)

Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway

Frontiers in Immunology, 2021
The complement system is central to first-line defense against invading pathogens. However, excessive complement activation and/or the loss of complement regulation contributes to the development of autoimmune diseases, systemic inflammation, and ...
Jonathan Barratt, Jonathan Barratt, Ilene Weitz   +2 more
doaj   +1 more source

The Lectin Pathway of Complement Activation Is a Critical Component of the Innate Immune Response to Pneumococcal Infection [PDF]

, 2012
The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Ali, Youssif M., Andrew, Peter W., Dudler, Thomas, Endo, Yuichi, Fujita, Teizo, Girija, Umakhanth V., Haleem, Kashif S., Hansen, Soren, Holmskov, Uffe, Kadioglu, Aras, Lynch, Nicholas J., Schwaeble, Wilhelm J., Stahl, Gregory L., Stover, Cordula M., Takahashi, Kazue, Wallis, Russell   +15 more
core   +4 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Pentraxins in Complement Activation and Regulation

Frontiers in Immunology, 2018
The complement is the first line of immune defense system involved in elimination of invading pathogens and dying host cells. Its activation is mainly triggered by immune complexes or pattern recognition molecules (PRMs) upon recognition against non-self
Ying Jie Ma, Peter Garred
doaj   +1 more source

Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF [PDF]

, 2016
Cholesterol crystals are known to be a hallmark of atherosclerosis with recent studies demonstrating deposition of these crystals in early fatty streak formation as well as penetrating the intima following plaque rupture.
Espevik, Terje, Mollnes, Tom Eirik, Niyonzima, Nathalie, Nymo, Stig Haugset   +3 more
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

VERSATILITY OF THE COMPLEMENT SYSTEM IN NEUROINFLAMMATION, NEURODEGENERATION AND BRAIN HOMEOSTASIS

Frontiers in Cellular Neuroscience, 2014
The immune response after brain injury is highly complex and involves both local and systemic events at the cellular and molecular level. It is associated to a dramatic over-activation of enzyme systems, the expression of proinflammatory genes and the ...
Franca eOrsini, Daiana eDe Blasio, Daiana eDe Blasio, Rosalia eZangari, Rosalia eZangari, Elisa R. Zanier, Maria-Grazia eDe Simoni   +6 more
doaj   +1 more source

Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking

Nature Communications, 2021
Understanding nanomaterials interactions with complement is important for a number of applications. Here, the authors study the interaction of sub 6 nm dendrimers with complement and show the small dendrimers escape complement activation but do interact ...
Lin-Ping Wu, Mario Ficker, Jørn B. Christensen, Dmitri Simberg, Panagiotis N. Trohopoulos, Seyed M. Moghimi   +5 more
doaj   +1 more source

Complement activation by recombinant adenoviruses [PDF]

Gene Therapy, 2001
Recombinant adenoviruses are currently the most important vector system in gene therapy. Adenoviruses frequently cause upper respiratory tract infections in humans and anti-adenoviral antibodies are found in 35-70% of the population. Therefore in the majority of potential patients receiving adenoviral gene therapy, the contact of virus particles and ...
Cichon, G, Boeckh-Herwig, S, Schmidt, HH, Wehnes, E, Müller, T, Pring-Akerblom, P, Burger, R   +6 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source