Results 61 to 70 of about 2,294,616 (302)

The Human Platelet as an Innate Immune Cell: Interactions Between Activated Platelets and the Complement System

Frontiers in Immunology, 2019
Platelets play an essential role in maintaining homeostasis in the circulatory system after an injury by forming a platelet thrombus, but they also occupy a central node in the intravascular innate immune system.
Oskar Eriksson, Camilla Mohlin, Bo Nilsson, Kristina N. Ekdahl, Kristina N. Ekdahl   +4 more
doaj   +1 more source

Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking

Nature Communications, 2021
Understanding nanomaterials interactions with complement is important for a number of applications. Here, the authors study the interaction of sub 6 nm dendrimers with complement and show the small dendrimers escape complement activation but do interact ...
Lin-Ping Wu, Mario Ficker, Jørn B. Christensen, Dmitri Simberg, Panagiotis N. Trohopoulos, Seyed M. Moghimi   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Sample processing time but not storage time affects complement activation markers C4a, C4d, C3a, iC3b, Bb, C5a, and sC5b-9 levels in EDTA-plasma of individuals at clinical high-risk for psychosis

Biomarkers in Neuropsychiatry
The complement system is an important part of the innate immune system and plays a key role in inflammatory processes. Concentrations of complement activation fragments in plasma are markers of systemic activation and have been found to be altered in a ...
Eleftheria Kodosaki, Colm Healy, Jonah F. Byrne, Melanie Föcking, Mary Cannon, Diana O. Perkins, David Cotter, Meike Heurich   +7 more
doaj   +1 more source

Complement and Cancer—A Dysfunctional Relationship?

Antibodies, 2020
Although it was long believed that the complement system helps the body to identify and remove transformed cells, it is now clear that complement activation contributes to carcinogenesis and can also help tumors to escape immune-elimination.
Joshua M. Thurman, Jennifer Laskowski, Raphael A. Nemenoff   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Hematopoietic cell transplantation-associated thrombotic microangiopathy: a review of pathophysiology, diagnosis, and treatment

Journal of Blood Medicine, 2016
Joseph Rosenthal Department of Pediatrics, City of Hope National Medical Center, Duarte, CA, USA Abstract: Transplant-associated thrombotic microangiopathy (TA-TMA) is a multifactorial disorder caused by systemic vascular endothelial injury that can be ...
Rosenthal J
doaj  

VERSATILITY OF THE COMPLEMENT SYSTEM IN NEUROINFLAMMATION, NEURODEGENERATION AND BRAIN HOMEOSTASIS

Frontiers in Cellular Neuroscience, 2014
The immune response after brain injury is highly complex and involves both local and systemic events at the cellular and molecular level. It is associated to a dramatic over-activation of enzyme systems, the expression of proinflammatory genes and the ...
Franca eOrsini, Daiana eDe Blasio, Daiana eDe Blasio, Rosalia eZangari, Rosalia eZangari, Elisa R. Zanier, Maria-Grazia eDe Simoni   +6 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Identification and functional characterisation of Complement Regulator Acquiring Surface Protein-1 of serum resistant Borrelia garinii OspA serotype 4 [PDF]

, 2010
Background: B. burgdorferi sensu lato (sl) is the etiological agent of Lyme borreliosis in humans. Spirochetes have adapted themselves to the human immune system in many distinct ways.
Peter F. Zipfel, Dam, A.P. van, Schuijt, Tim J., Kraiczy, Peter, Nathalie D. van Burgel, Nathalie D. van Burgel, van Burgel Nathalie D, Burgel, N.D. van, Burgel, Nathalie D. van, Schuijt Tim J, Tim J. Schuijt, Kraiczy Peter, Schuijt, T.J., van Dam Alje P, Zipfel Peter F, Kraiczy, P., Zipfel, Peter F., Alje P. van Dam, Peter Kraiczy, Zipfel, P.F., Dam, Alje P. van   +20 more
core   +1 more source