Results 81 to 90 of about 651,857 (304)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Plasma complement biomarkers distinguish multiple sclerosis and neuromyelitis optica spectrum disorder [PDF]

, 2016
Background: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are autoimmune demyelinating diseases distinguished clinically by selective involvement in NMOSD of optic nerves and spinal cord. Early clinical manifestations are
Evans, David R. S., Hakobyan, Svetlana, Harding, Katharine, Loveless, Samantha, Luppe, Sebastian, Morgan, Bryan Paul, Robertson, Neil P.   +6 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Complement Activation in Inflammatory Skin Diseases

Frontiers in Immunology, 2018
The complement system is a fundamental part of the innate immune system, playing a crucial role in host defense against various pathogens, such as bacteria, viruses, and fungi. Activation of complement results in production of several molecules mediating
Jenny Giang, Marc A. J. Seelen, Martijn B. A. van Doorn, Robert Rissmann, Errol P. Prens, Jeffrey Damman   +5 more
doaj   +1 more source

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M, Kishore, U, Kouser, L, Nayak, A, Sim, RB, Stover, CM   +5 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Complement activation in human prion disease

Neurobiology of Disease, 2004
The central event in the neuropathological process of prion diseases (PrD) is the accumulation of abnormal prion protein accompanied by severe neuronal loss.
Gabor G Kovacs, Philippe Gasque, Thomas Ströbel, Elisabeth Lindeck-Pozza, Michaela Strohschneider, James W Ironside, Herbert Budka, Marin Guentchev   +7 more
doaj   +1 more source

Human complement factor H. Two factor H proteins are derived from alternatively spliced transcripts [PDF]

, 1991
The human complement factor H is an important component in the control of the alternative pathway of complement activation. We have previously shown that at least three factor H homologous mRNA species of 4.3 kb, 1.8 kb and 1.4 kb in length are ...
Alsenz, Alsenz, Aruffo, Chirgwin, Church, Conrad, Day, Feinberg, Fontaine, Kristensen, Laemmli, Maniatis, McAleer, Misasi, Pangburn, Ripoche, Schulz, Schulz, Schwaeble, Seed, Sim, Towbin, Whaley, Whaley   +23 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets

Haematologica, 2019
High titers of HLA antibodies are associated with platelet refractoriness, causing poor platelet increments after transfusions in a subset of patients with HLA antibodies.
Maaike Rijkers, David Schmidt, Nina Lu, Cynthia S.M. Kramer, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Frank W.G. Leebeek, A.J. Gerard Jansen, Ilse Jongerius, Sacha S. Zeerleder, Gestur Vidarsson, Jan Voorberg, Masja de Haas   +14 more
doaj   +1 more source