Results 91 to 100 of about 651,857 (304)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Complexity of Finding Effectors

, 2015
The NP-hard EFFECTORS problem on directed graphs is motivated by applications in network mining, particularly concerning the analysis of probabilistic information-propagation processes in social networks.
Bulteau, Laurent, Fafianie, Stefan, Froese, Vincent, Niedermeier, Rolf, Talmon, Nimrod   +4 more
core   +1 more source

Material properties in complement activation

Advanced Drug Delivery Reviews, 2011
Uncontrolled complement activation can induce many inflammatory and life threatening conditions. Accordingly, the role of complement in initiation of adverse reactions to polymers and nanoparticulate drug carriers is receiving increasing attention and has prompted extensive 'structure-immune performance' relationship studies in nanomedicine research at
Moghimi, Seyed Moein, Andersen, Alina Joukainen, Ahmadvand, Davoud, Wibroe, Peter P., Andresen, Thomas Lars, Hunter, A. Christy   +5 more
openaire   +4 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Editorial: The complement system in autoimmunity

Frontiers in Immunology, 2022
Eveline Y. Wu, Eveline Y. Wu, Jessy J. Alexander, Shoichi Fukui, Shoichi Fukui, Shoichi Fukui, Shoichi Fukui   +6 more
doaj   +1 more source

Trichinella spiralis Calreticulin Binds Human Complement C1q As an Immune Evasion Strategy

Frontiers in Immunology, 2017
As a multicellular parasitic nematode, Trichinella spiralis regulates host immune responses by producing a variety of immunomodulatory molecules to escape from host immune attack, but the mechanisms underlying the immune evasion are not well understood ...
Limei Zhao, Limei Zhao, Shuai Shao, Shuai Shao, Yi Chen, Yi Chen, Ximeng Sun, Ximeng Sun, Ran Sun, Jingjing Huang, Jingjing Huang, Bin Zhan, Xinping Zhu, Xinping Zhu   +13 more
doaj   +1 more source

Complementing antibody profiles: Assessing antibody function on antigen microarrays [PDF]

, 2012
Antibody effector functions other than neutralization depend on interactions with soluble and cellular components of the immune system. Antigen recognition is usually oligoclonal, with the different clones of antibodies belonging to different ...
Papp, Krisztián, Prechl, József, Szittner, Zoltán   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Complement activation in wasp venom-induced acute kidney injury

Renal Failure
Previous studies have highlighted the significant role of complement activation in kidney injuries induced by rhabdomyolysis, intravascular hemolysis, sepsis, and ischemia-reperfusion.
Rui Cheng, Liang Xu, Jianhua Gong, Fanglin Yu, Ying Lv, Hai Yuan, Fengqi Hu   +6 more
doaj   +1 more source

Complement Evasion: An Effective Strategy That Parasites Utilize to Survive in the Host

Frontiers in Microbiology, 2019
Parasitic infections induce host immune responses that eliminate the invading parasites. However, parasites have evolved to develop many strategies to evade host immune attacks and survive in a hostile environment. The complement system acts as the first
Shuai Shao, Ximeng Sun, Yi Chen, Bin Zhan, Xinping Zhu   +4 more
doaj   +1 more source