Results 21 to 30 of about 2,166,159 (300)

Complement activation and protein adsorption by carbon nanotubes [PDF]

, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel, Sim, Robert B., Sloan, Jeremy, Green, Malcolm L.H., Sim, Edith, Salvador-Morales, Carolina, Green, Malcolm L. H.   +6 more
core   +1 more source

Pulmonary complement depositions in autopsy of critically ill patients have no relation with ARDS

Intensive Care Medicine Experimental, 2019
Background The complement system has frequently been suggested to play a role in the pathophysiology of acute respiratory distress syndrome (ARDS).
Friso M. de Beer, Mark P. V. Begieneman, Joris J. T. H. Roelofs, Janneke Horn, Hans W. M. Niessen, Marcus J. Schultz, Wim K. Lagrand   +6 more
doaj   +1 more source

Engineering novel complement activity into a pulmonary surfactant protein [PDF]

, 2010
Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Toth, Julia, Wilhelm J. Schwaeble, Christopher Furze, Russell Wallis, Keeble, A. H., Julia Toth, Keeble, Anthony H., Girija, Umakhanth Venkatraman, Wallis, Russell, Mitchell, D. A., Daniel A. Mitchell, Toth, J., Schwaeble, W. J., Schwaeble, Wilhelm J., Anthony H. Keeble, Furze, C., Umakhanth Venkatraman Girija, Furze, Christopher M., Mitchell, Daniel A., Wallis, R., Venkatraman Girija, U.   +20 more
core   +1 more source

The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation

Clinical & Translational Immunology, 2023
Objectives The complement system is an important component of innate immunity. The alternative pathway (AP) amplification loop is considered an essential feed forward mechanism for complement activation.
Esther CW deBoer, Astrid JF Thielen, Jeroen D Langereis, Angela Kamp, Mieke C Brouwer, Nienke Oskam, Marlieke L Jongsma, April J Baral, Robbert M Spaapen, Sacha Zeerleder, Gestur Vidarsson, Theo Rispens, Diana Wouters, Richard B Pouw, Ilse Jongerius   +14 more
doaj   +1 more source

COMPLEMENT-MEDIATED ADIPOCYTE LYSIS BY NEPHRITIC FACTOR SERA [PDF]

, 1993
Recent data indicate a previously unsuspected link between the complement system and adipocyte biology. Murine adipocytes produce key components of the alternative pathway of complement and are able to activate this pathway.
Lachmann, PJ, Peters, DK, P J Lachmann, D K Peters, P W Mathieson, Oliveira, DBG, R Würzner, D B Oliveria, Mathieson, PW, Würzner, R, Oliveria, DB   +10 more
core   +1 more source

Leukocyte sequestration in pulmonary microvessels and lung injury following systemic complement activation in rabbits [PDF]

, 1999
Inflammatory reactions are associated with sequestration of leukocytes in the lung. Complement activation leads to accumulation of leukocytes in alveolar septa and alveoli, to lung edema and hemorrhage.
Kuhnle, Gerhard E. H., Kuebler, Wolfgang M., Kiefmann, Rainer, Groh, Joachim, Goetz, Alwin Eduard, Sckell, Axel   +5 more
core   +1 more source

A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB. [PDF]

, 2010
Viruses have evolved to evade the host's complement system. The open reading frames 4 (ORF4) of gammaherpesviruses encode homologs of regulators of complement activation (RCA) proteins, which inhibit complement activation at the level of C3 and C4 ...
Stewart, James P., Stipan, J., Adler, Heiko, James P Stewart, Adler Barbara, Adler, Barbara, Heiko Adler, Beatrix Steer, Barbara Adler, Jonjic Stipan, Stipan Jonjic, Steer, Beatrix, Steer Beatrix, Steer, B., Adler Heiko, Stewart James P., Adler, H., Adler, B., Jonjic, Stipan, James P. Stewart, Stewart, J.P.   +20 more
core   +1 more source

Clinical relevance of glomerular IgM deposition in patients with lupus nephritis

BMC Immunology, 2021
Background The aim of the study was to investigate the clinical relevance of IgM deposition in patients with lupus nephritis (LN) in a large cohort. Results 217 patients with renal biopsy-proven active LN were enrolled.
Fengmei Wang, Jirong Yu, Lei Zhang, Yan Zhang, Jie Zhang, Bicheng Liu, Xiaowei Yang   +6 more
doaj   +1 more source

Acidosis activates complement system in vitro

Mediators of Inflammation, 1998
We investigated the in vitro effect of different form s of acidosis (pH 7.0) on the formation of anaphylatoxins C3a and C5a. Metabolic acidosis due to addition of hydrochloric acid (10 μ mol/ml blood) or lactic acid (5.5 μ mol/ml) to heparin blood (N=12)
Michael Emeis, Josef Sonntag, Carsten Willam, Evelyn Strauss, Matthias M. Walka, Michael Obladen   +5 more
doaj   +1 more source

Using animal models to determine the significance of complement activation in Alzheimer's disease

Journal of Neuroinflammation, 2004
Complement inflammation is a major inflammatory mechanism whose function is to promote the removal of microorganisms and the processing of immune complexes.
Loeffler David A
doaj   +1 more source