Results 21 to 30 of about 2,294,616 (302)

Using animal models to determine the significance of complement activation in Alzheimer's disease

Journal of Neuroinflammation, 2004
Complement inflammation is a major inflammatory mechanism whose function is to promote the removal of microorganisms and the processing of immune complexes.
Loeffler David A
doaj   +1 more source

Essential Role of Complement in Pregnancy: From Implantation to Parturition and Beyond

Frontiers in Immunology, 2020
The complement cascade was identified over 100 years ago, yet investigation of its role in pregnancy remains an area of intense research. Complement inhibitors at the maternal-fetal interface prevent inappropriate complement activation to protect the ...
Guillermina Girardi, Joshua J. Lingo, Sherry D. Fleming, Jean F. Regal   +3 more
doaj   +1 more source

Complement-Coagulation Cross-Talk: A Potential Mediator of the Physiological Activation of Complement by Low pH. [PDF]

, 2015
The complement system is a major constituent of the innate immune system. It not only bridges innate and adaptive arms of the immune system but also links the immune system with the coagulation system.
H. I. Kenawy (7637687), Alan Bevington (7240580), Ismet Boral (7637690)   +2 more
core   +3 more sources

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b [PDF]

, 2012
Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel, Christine Skerka, Kraiczy, Peter, Michael Reuter, Reuter, Michael, Skerka, Christine, Barthel, Diana, Diana Barthel, Koch, Tina K., Elsen, Jean van den, Böhm, Sascha, Zipfel, Peter F., Jean van den Elsen, Peter Kraiczy, Tina K Koch, Sascha Böhm, Peter F Zipfel, Tina K. Koch, Kraiczy Peter, Böhm Sascha, van den Elsen Jean, Koch Tina K., Skerka Christine, Reuter Michael, Zipfel Peter F., Barthel Diana   +25 more
core   +1 more source

Complement-Activating Capacity of Autoantibodies Correlates With Disease Activity in Bullous Pemphigoid Patients

Frontiers in Immunology, 2018
Background: Bullous pemphigoid is a subepidermal blistering skin disease, associated with autoantibodies to hemidesmosomal proteins, complement activation at the dermal-epidermal junction, and dermal granulocyte infiltration.
Roxana M. Chiorean, Roxana M. Chiorean, Adrian Baican, Mayson B. Mustafa, Annette Lischka, Daniel-Corneliu Leucuta, Vasile Feldrihan, Michael Hertl, Cassian Sitaru, Cassian Sitaru   +9 more
doaj   +1 more source

Beyond Binding: The Outcomes of Antibody-Dependent Complement Activation in Human Malaria

Frontiers in Immunology, 2021
Antibody immunity against malaria is effective but non-sterile. In addition to antibody-mediated inhibition, neutralisation or opsonisation of malaria parasites, antibody-mediated complement activation is also important in defense against infection ...
Dilini Rathnayake, Elizabeth H. Aitken, Stephen J. Rogerson   +2 more
doaj   +1 more source

Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces [PDF]

, 2004
The regulators of complement activation (RCA) are critical to health and disease because their role is to ensure that a complement-mediated immune response to infection is proportionate and targeted.
Krystyna Bromek, Uhrin, D, O'Leary, JM, Xuefeng Wang, Stanislava Uhrinova, Joanne M. O'Leary, Black, GM, Wang, XF, Malgorzata Krych, John P. Atkinson, Uhrinova, S, Dusan Uhrin, Atkinson, JP, Gordon M. Black, Krych, M, Schmitz, C, Paul N. Barlow, Bromek, K, Barlow, PN, Christian Schmitz   +19 more
core   +1 more source

Plasma samples from mouse strains and humans demonstrate different in vitro susceptibilities to complement activation

Precision Nanomedicine, 2018
Complement activation can be evaluated in vitro using plasma or serum from animals and human donors, and in vivo using animal models. Despite many years of research, there is no harmonized approach for the selection of matrix and animal models. Herein,
Barry W Neun, Gábor Szénási, János Szebeni, Marina Dobrovolskaia   +3 more
doaj   +1 more source

Carbohydrate recognition and complement activation by rat ficolin-B [PDF]

, 2010
Ficolins are innate immune components that bind to PAMPs and structures on apoptotic cells. Humans produce two serum forms (L-and H-ficolin) and a leukocyte-associated form (M-ficolin), whereas rodents and most other mammals produce ficolins-A and -B ...
Roscher, Silke, Umakhanth Venkatraman Girija, Russell Wallis, Mitchell, Daniel A., Girija, Umakhanth Venkatraman, Wallis, Russell, Wallis, R., Mitchell, D. A., Venkatraman Girija, U., Roscher, S., Daniel A. Mitchell, Silke Roscher   +11 more
core   +1 more source

Early complementopathy predicts the outcomes of patients with trauma

Trauma Surgery & Acute Care Open, 2019
Background Complementopathy (rapid complement activation and consumption after trauma) has been reported in trauma patients, but the underlying mechanism of these phenomena and their clinical significance remain unclear. This study aimed to determine the
Bin Liu, Yansong Li, Qingwei Zhao, Alexander Dixon, Leopoldo Cancio, Michael Dubick, Jurandir Dalle Lucca   +6 more
doaj   +1 more source