Results 31 to 40 of about 2,166,159 (300)

Essential Role of Complement in Pregnancy: From Implantation to Parturition and Beyond

Frontiers in Immunology, 2020
The complement cascade was identified over 100 years ago, yet investigation of its role in pregnancy remains an area of intense research. Complement inhibitors at the maternal-fetal interface prevent inappropriate complement activation to protect the ...
Guillermina Girardi, Joshua J. Lingo, Sherry D. Fleming, Jean F. Regal   +3 more
doaj   +1 more source

Beyond Binding: The Outcomes of Antibody-Dependent Complement Activation in Human Malaria

Frontiers in Immunology, 2021
Antibody immunity against malaria is effective but non-sterile. In addition to antibody-mediated inhibition, neutralisation or opsonisation of malaria parasites, antibody-mediated complement activation is also important in defense against infection ...
Dilini Rathnayake, Elizabeth H. Aitken, Stephen J. Rogerson   +2 more
doaj   +1 more source

Complement-Activating Capacity of Autoantibodies Correlates With Disease Activity in Bullous Pemphigoid Patients

Frontiers in Immunology, 2018
Background: Bullous pemphigoid is a subepidermal blistering skin disease, associated with autoantibodies to hemidesmosomal proteins, complement activation at the dermal-epidermal junction, and dermal granulocyte infiltration.
Roxana M. Chiorean, Roxana M. Chiorean, Adrian Baican, Mayson B. Mustafa, Annette Lischka, Daniel-Corneliu Leucuta, Vasile Feldrihan, Michael Hertl, Cassian Sitaru, Cassian Sitaru   +9 more
doaj   +1 more source

Plasma samples from mouse strains and humans demonstrate different in vitro susceptibilities to complement activation

Precision Nanomedicine, 2018
Complement activation can be evaluated in vitro using plasma or serum from animals and human donors, and in vivo using animal models. Despite many years of research, there is no harmonized approach for the selection of matrix and animal models. Herein,
Barry W Neun, Gábor Szénási, János Szebeni, Marina Dobrovolskaia   +3 more
doaj   +1 more source

Profiling Complement System Components in Primary CNS Vasculitis

Cells, 2021
Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji, Christian W. Keller, Simon Koch, Heinz Wiendl, Christian Gerloff, Tim Magnus, Jan D. Lünemann   +6 more
doaj   +1 more source

Early complementopathy predicts the outcomes of patients with trauma

Trauma Surgery & Acute Care Open, 2019
Background Complementopathy (rapid complement activation and consumption after trauma) has been reported in trauma patients, but the underlying mechanism of these phenomena and their clinical significance remain unclear. This study aimed to determine the
Bin Liu, Yansong Li, Qingwei Zhao, Alexander Dixon, Leopoldo Cancio, Michael Dubick, Jurandir Dalle Lucca   +6 more
doaj   +1 more source

Complement Proteins as Soluble Pattern Recognition Receptors for Pathogenic Viruses

Viruses, 2021
The complement system represents a crucial part of innate immunity. It contains a diverse range of soluble activators, membrane-bound receptors, and regulators.
Valarmathy Murugaiah, Praveen M. Varghese, Nazar Beirag, Syreeta De Cordova, Robert B. Sim, Uday Kishore   +5 more
doaj   +1 more source

Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1

, 2010
It has been reported that complement is activated on the surface of activated platelets, despite the presence of multiple regulators of complement activation. To reinvestigate the mechanisms by which activated platelets bind to complement components, the
Nilsson Ekdahl, Kristina,, Lambris, John D., Hamad, Osama A.,, Hamad, Osama, Nilsson, Per H., Nilsson, Bo,, Hamad, Osama A., Nilsson, Per H.,, Ekdahl, Kristina N.,, Ekdahl, Kristina N., Wouters, Diana, Nilsson, Bo, Lambris, John   +12 more
core   +1 more source

Carbohydrate recognition and complement activation by rat ficolin-B [PDF]

, 2010
Ficolins are innate immune components that bind to PAMPs and structures on apoptotic cells. Humans produce two serum forms (L-and H-ficolin) and a leukocyte-associated form (M-ficolin), whereas rodents and most other mammals produce ficolins-A and -B ...
Roscher, Silke, Umakhanth Venkatraman Girija, Russell Wallis, Mitchell, Daniel A., Girija, Umakhanth Venkatraman, Wallis, Russell, Wallis, R., Mitchell, D. A., Venkatraman Girija, U., Roscher, S., Daniel A. Mitchell, Silke Roscher   +11 more
core   +1 more source

Complement Activation and Inhibition in Wound Healing

Clinical and Developmental Immunology, 2012
Complement activation is needed to restore tissue injury; however, inappropriate activation of complement, as seen in chronic wounds can cause cell death and enhance inflammation, thus contributing to further injury and impaired wound healing. Therefore,
Gwendolyn Cazander, Gerrolt N. Jukema, Peter H. Nibbering   +2 more
doaj   +1 more source