Results 41 to 50 of about 392,488 (288)

Structural basis for complement factor H-linked age-related macular degeneration [PDF]

, 2007
Nearly 50 million people worldwide suffer from age-related macular degeneration (AMD), which causes severe loss of central vision. A single-nucleotide polymorphism in the gene for the complement regulator factor H (FH), which causes a Tyr-to-His ...
Pietro Roversi, Clark, S, Robert B. Sim, Susan M. Lea, Jowitt, Thomas A., Beverly E. Prosser, Prosser, Beverly E., Prosser, B, Day, Anthony J., Herbert, AP, Dušan Uhrín, Sim, Robert B., Uhrin, Dusan, Barlow, P, Johnson, S, Lea, SM, Steven Johnson, Blaum, Barbel S., Barlow, Paul N., Herbert, A, Barlow, PN, Sim, RB, Simon J. Clark, Roversi, P, Uhrín, D, Johnson, Steven, Thomas A. Jowitt, Day, A, Jowitt, Thomas A.; id_orcid, Edward Tarelli, Jess Tyrrell, Lea, Susan M., Tyrrell, J, Blaum, BS, Herbert, Andrew P., Clark, Simon J., Tyrrell, Jess, Day, Anthony J.; id_orcid, Lea, Susan, Tarelli, E, Clark, SJ, Paul N. Barlow, Bärbel S. Blaum, Clark, Simon; id_orcid, Tarelli, Edward, Prosser, BE, Jowitt, TA, Day, AJ, Andrew P. Herbert, Roversi, Pietro, Anthony J. Day   +50 more
core   +1 more source

Alternative complement pathway deregulation is correlated with dengue severity. [PDF]

PLoS ONE, 2009
BACKGROUND:The complement system, a key component that links the innate and adaptive immune responses, has three pathways: the classical, lectin, and alternative pathways. In the present study, we have analyzed the levels of various complement components
Eduardo J M Nascimento, Ana M Silva, Marli T Cordeiro, Carlos A Brito, Laura H V G Gil, Ulisses Braga-Neto, Ernesto T A Marques   +6 more
doaj   +1 more source

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity [PDF]

, 2009
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
Schott, Melanie, Sonja Grosskinsky, Markus M. Simon, Grosskinsky, Sonja, Cutler, Sally J., Schott, M., Simon, M., Kraiczy, P., Zipfel, Peter F., Grosskinsky, S., Peter Kraiczy, Sally J Cutler, Peter F Zipfel, Peter F. Zipfel, Brenner, Christiane, Wallich, R., Kraiczy, Peter, Brenner, C., Christiane Brenner, Simon, Markus M., Markus M Simon, Wallich, Reinhard, Sally J. Cutler, Reinhard Wallich, Cutler, S., Zipfel, P., Melanie Schott   +26 more
core   +1 more source

Solubilization of immune precipitates by complement in the absence of properdin or factor D [PDF]

FEBS Letters, 1988
Various experiments have demonstrated that immune precipitates (IPs) are not solubilized by complement in the absence of alternative pathway function. To determine whether the characteristics of the IPs were responsible for these observations, we studied the solubilization (Sol) of IPs formed by bovine serum albumin (BSA)‐rabbit antiBSA and tetanus ...
Späth, P.J., Pascual, M., Meyer-Hänni, Liselotte, Schaad, U.B., Schifferli, J.A.   +4 more
openaire   +2 more sources

Recombinant complement factor H in complement-mediated diseases [PDF]

, 2022
Complement Factor H (FH) is a 155-kDa plasma glycoprotein that regulates the alternative pathway of the complement system. Mutations or deficiencies in FH are associated with some cases of the kidney diseases C3 glomerulopathy and atypical ...
Kerr, Heather
core   +1 more source

Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Endothelial microparticles are associated with chronic kidney disease (CKD) and complement activation. We hypothesized that the complement pathway is activated in patients with CKD via endothelial microparticles and that complement activation ...
Diana Jalal, Brandon Renner, Jennifer Laskowski, Erik Stites, James Cooper, Karissa Valente, Zhiying You, Loni Perrenoud, Moglie Le Quintrec, Ismaeel Muhamed, Uwe Christians, Jelena Klawitter, Margaret A. Lindorfer, Ronald P. Taylor, V. Michael Holers, Joshua M. Thurman   +15 more
doaj   +1 more source

Biochemical and functional studies of a novel complement inhibitor, CRIT, with its interaction partners [PDF]

, 2005
Complement C2 receptor trispanning (CRIT), a three transmembrane receptor, was first discovered on the surface of the parasite Schistosoma haematobium and formerly termed Schistosoma trispanning orphan receptor (Sh-TOR). This receptor acts as decoy C2-
Hui, Kwok-Min
core   +1 more source

CipA mediates complement resistance of Acinetobacter baumannii by formation of a factor I-dependent quadripartite assemblage

Frontiers in Immunology, 2022
Multidrug-resistant Acinetobacter baumannii is known to be one of the leading pathogens that cause severe nosocomial infections. To overcome eradication by the innate immune system during infection, A.
Julia I. Ries, Marie Heß, Noura Nouri, Thomas A. Wichelhaus, Stephan Göttig, Franco H. Falcone, Peter Kraiczy   +6 more
doaj   +1 more source

Pneumococcal histidine triad proteins are regulated by the Zn(2+)-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H [PDF]

, 2009
The pneumococcal histidine triad (Pht) proteins are a recently recognized family of surface proteins, comprising 4 members: PhtA, PhtB, PhtD, and PhtE. They are being promoted for inclusion in a multicomponent pneumococcal protein vaccine currently under
Sadlon, T., Cook, J., Sadlon, Tania A., Mahdi, Layla K., Ogunniyi, A., Paton, James Cleland, Cook, Jan, Paton, J., Ogunniyi, A D, Gordon, David Llewellyn, Ogunniyi, Abiodun D., Sadlon, Tania, Grabowicz, Marcin, Paton, James C., Grabowicz, M., Gordon, D., Gordon, David L., Mahdi, L.   +17 more
core   +1 more source

Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors. [PDF]

ACS Med Chem Lett, 2016
Aberrant activation of the complement system is associated with diseases, including paroxysmal nocturnal hemoglobinuria and age-related macular degeneration.
Yang CY, Phillips JG, Stuckey JA, Bai L, Sun H, Delproposto J, Brown WC, Chinnaswamy K.   +7 more
europepmc   +2 more sources