Results 11 to 20 of about 392,488 (288)

Urinary complement factor D is increased in primary malignant hypertension: a single-center, cross-sectional study [PDF]

Scientific Reports
Kidney injury is one of the detrimental consequences of primary malignant hypertension (pMHTN). There is a paucity of non-invasive biomarkers to enhance diagnosis and elucidate the underlying mechanisms.
Yaqi Cheng, Weiwei Qin, Liling Lin, Youhe Gao, Mingxi Li   +4 more
doaj   +2 more sources

Complement factor D (adipsin) mediates pressure-pain hypersensitivity post destabilization of medial meniscus injury [PDF]

Arthritis Research & Therapy
Background Osteoarthritis (OA) is the leading cause of pain worldwide. However, clinical discordance between pain and cartilage damage presents challenges in determining the mechanisms of OA pain, thus creating a need for well-controlled models that ...
Priscilla M. Tjandra, Bethany A. Andoko, Jooyoung A. Kim, Jacob G. Brockert, Andreana G. Gomez, Sonya Sar, Megha R. Aepala, Tiffany T.K. Pham, Darren Dumlao, Hope D. Welhaven, Kelsey H. Collins   +10 more
doaj   +2 more sources

Complement factor D in age-related macular degeneration. [PDF]

Invest Ophthalmol Vis Sci, 2011
To examine the role of complement factor D (CFD) in age-related macular degeneration (AMD) by analysis of genetic association, copy number variation, and plasma CFD concentrations.Single nucleotide polymorphisms (SNPs) in the CFD gene were genotyped and the results analyzed by binary logistic regression.
Stanton CM, Yates JR, den Hollander AI, Seddon JM, Swaroop A, Stambolian D, Fauser S, Hoyng C, Yu Y, Atsuhiro K, Branham K, Othman M, Chen W, Kortvely E, Chalmers K, Hayward C, Moore AT, Dhillon B, Ueffing M, Wright AF.   +19 more
europepmc   +6 more sources

Small Molecule-Induced Complement Factor D (Adipsin) Promotes Lipid Accumulation and Adipocyte Differentiation. [PDF]

PLoS ONE, 2016
Adipocytes are differentiated by various transcriptional cascades integrated on the master regulator, Pparγ. To discover new genes involved in adipocyte differentiation, preadipocytes were treated with three newly identified pro-adipogenic small ...
No-Joon Song, Suji Kim, Byung-Hyun Jang, Seo-Hyuk Chang, Ui Jeong Yun, Ki-Moon Park, Hironori Waki, Dean Y Li, Peter Tontonoz, Kye Won Park   +9 more
doaj   +2 more sources

Adsorption of complement factor D by polyacrylonitrile dialysis membranes [PDF]

Kidney International, 1993
Factor D, an essential enzyme of the alternative pathway (AP) of complement, accumulates in end-stage renal failure (ESRF). Polyacrylonitrile (PAN) membrane activates complement poorly and has been shown to adsorb C3a, the main anaphylatoxin released during complement activation. In the present work we investigated whether factor D might be adsorbed on
Pascual M, Schifferli JA
openaire   +4 more sources

Metabolism of complement factor D in renal failure [PDF]

Kidney International, 1988
Factor D is an essential enzyme of the alternative pathway of complement. Its plasma concentration increases approximately tenfold in end-stage renal failure (ESRF). To analyze its metabolism in humans, we injected purified radiolabelled factor D into 5 healthy individuals and 12 patients with various renal diseases or renal failure.
Pascual M, Steiger G, Estreicher J, Macon K, Volanakis JE, Schifferli JA   +5 more
openaire   +4 more sources

Association of Complement Factor D and H Polymorphisms with Recurrent Pregnancy Loss. [PDF]

Int J Mol Sci, 2019
Recurrent pregnancy loss (RPL) is defined as two or more consecutive pregnancy losses prior to 20 weeks of gestation, and the incidence of RPL is estimated at 1% of all pregnancies. While the etiologies of RPL are diverse, immune function is considered to be an important cause of RPL.
Cho HY, Park HS, Ko EJ, Ryu CS, Kim JO, Kim YR, Ahn EH, Lee WS, Kim NK.   +8 more
europepmc   +4 more sources

Mesangial immune complex glomerulonephritis due to complement factor D deficiency [PDF]

Kidney International, 2007
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.
Abrera-Abeleda, M.A., Xu, Y., Pickering, M.C., Smith, R.J.H., Sethi, S.   +4 more
openaire   +4 more sources

Inhibition of degranulation of human polymorphonuclear leukocytes by complement factor D [PDF]

FEBS Letters, 1995
A degranulation inhibiting protein could be isolated from human plasma ultrafiltrate by a three‐step purification method including ion‐exchange chromatography, gelfiltration and affinity‐chromatography. The protein was identified as complement factor D by means of sequence analysis.
BALKE, N, HOLTKAMP, U, HORL, WH, Tschesche, Harald   +3 more
openaire   +5 more sources

The effect of lutein supplementation on blood plasma levels of complement factor D, C5a and C3d. [PDF]

PLoS ONE, 2013
Lutein is selectively taken up by the primate retina and plays an important role as a filter for harmful blue light and as an antioxidant. Recent studies have shown that lutein has systemic anti-inflammatory properties. Dietary lutein has been associated
Yuan Tian, Aize Kijlstra, Rob L P van der Veen, Maria Makridaki, Ian J Murray, Tos T J M Berendschot   +5 more
doaj   +2 more sources