Results 11 to 20 of about 135,986 (295)

Alternative Complement Pathway Inhibition by Lampalizumab

Ophthalmology Science, 2023
Purpose: Lampalizumab, an antigen-binding fragment of a humanized monoclonal antibody directed against complement factor D (CFD), is designed to treat geographic atrophy (GA) secondary to age-related macular degeneration.
Rose Edmonds, MS, Verena Steffen, MSc, Lee A. Honigberg, PhD, Michael C. Chang, PhD   +3 more
doaj   +2 more sources

Complement alternative pathway activation in human nonalcoholic steatohepatitis. [PDF]

PLoS ONE, 2014
The innate immune system plays a major role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Recently we reported complement activation in human NASH.
Filip M Segers, Froukje J Verdam, Charlotte de Jonge, Bas Boonen, Ann Driessen, Ronit Shiri-Sverdlov, Nicole D Bouvy, Jan Willem M Greve, Wim A Buurman, Sander S Rensen   +9 more
doaj   +2 more sources

Alternative Complement Pathway Inhibition Abrogates Pneumococcal Opsonophagocytosis in Vaccine-Naïve, but Not in Vaccinated Individuals

Frontiers in Immunology, 2021
To assess the relative contribution of opsonisation by antibodies, classical and alternative complement pathways to pneumococcal phagocytosis, we analyzed killing of pneumococci by human blood leukocytes collected from vaccine-naïve and PCV13-vaccinated ...
Lukas Muri, Lukas Muri, Emma Ispasanie, Emma Ispasanie, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke, Gerd Pluschke   +10 more
doaj   +2 more sources

Autoantibodies against alternative complement pathway proteins in renal pathologies

Nefrología (English Edition), 2016
Complement system activation plays an important role in several renal pathologies, including antibody-mediated glomerulonephritis, ischaemia–reperfusion injury of transplanted kidneys or renal allograft rejection.
Pilar Nozal, Margarita López-Trascasa
doaj   +2 more sources

Activation of the Alternative Complement Pathway by Fonsecaea pedrosoi

Journal of Investigative Dermatology, 1984
Human sera were examined for evidence of complement activation by Fonsecaea pedrosoi. The serum that had been incubated with F. pedrosoi showed immunoelectrophoretic C3 conversion and generation of C5a, as measured by radioimmunoassay. C3 conversion and C5a generation did not occur in serum chelated with EDTA, or in serum heated to 56 degrees C for 30 ...
Torinuki, Wakio, Okohchi, Kyoko, Takematsu, Hideaki, Tagami, Hachiro   +3 more
openaire   +3 more sources

Blocking the alternative complement pathway [PDF]

Nature Reviews Drug Discovery, 2016
Sarah Crunkhorn
exaly   +2 more sources

Complement factor D is linked to platelet activation in human and rodent sepsis

Intensive Care Medicine Experimental, 2021
Background The complement factor D (CFD) exerts a regulatory role during infection. However, its physiological function in coagulopathy and its impact on the course of an infection remains unclear. Materials Wild-type and CFD-deficient mice (n = 91) were
O. Sommerfeld, K. Dahlke, M. Sossdorf, R. A. Claus, A. Scherag, M. Bauer, F. Bloos   +6 more
doaj   +1 more source

The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases

Frontiers in Immunology, 2021
The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu, Shaopeiwen Luo, Stefanie A. Ma, Priyanka Saminathan, Herman Li, Jenny M. Gunnersen, Harris A. Gelbard, Jennetta W. Hammond   +7 more
doaj   +1 more source

Complement Alternative and Mannose-Binding Lectin Pathway Activation Is Associated With COVID-19 Mortality

Frontiers in Immunology, 2021
BackgroundThe SARS-CoV-2 infection triggers excessive immune response resulting in increased levels of pro-inflammatory cytokines, endothelial injury, and intravascular coagulopathy.
Federica Defendi, Corentin Leroy, Corentin Leroy, Olivier Epaulard, Olivier Epaulard, Giovanna Clavarino, Antoine Vilotitch, Marion Le Marechal, Marie-Christine Jacob, Tatiana Raskovalova, Martine Pernollet, Audrey Le Gouellec, Audrey Le Gouellec, Jean-Luc Bosson, Pascal Poignard, Pascal Poignard, Matthieu Roustit, Matthieu Roustit, Nicole Thielens, Chantal Dumestre-Pérard, Chantal Dumestre-Pérard, Jean-Yves Cesbron   +21 more
doaj   +1 more source

The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation [PDF]

, 2023
OBJECTIVES: The complement system is an important component of innate immunity. The alternative pathway (AP) amplification loop is considered an essential feed forward mechanism for complement activation. However, the role of the AP in classical pathway (
Zeerleder, S., Mieke C Brouwer, Thielen, A.J., Spaapen, Robbert M, Boer, E.C. de, Rispens, Theo, Jongerius, Ilse, Ilse Jongerius, Spaapen, R.M., Rispens, T., Brouwer, Mieke C, Langereis, J.D., Angela Kamp, Esther CW deBoer, Langereis, Jeroen D, Marlieke L Jongsma, Diana Wouters, Kamp, Angela, Jongsma, Marlieke L, Pouw, Richard B, Theo Rispens, Kamp, A., Jongerius, I., Thielen, Astrid JF, Wouters, D., Baral, A.J., Sacha Zeerleder, Pouw, R.B., de Boer, Esther CW, Oskam, Nienke, Jongsma, Marlieke L., Jeroen D Langereis, Astrid JF Thielen, Brouwer, M.C.T., Baral, April J, Vidarsson, G., Esther CW de Boer, Zeerleder, Sacha, Wouters, Diana, Gestur Vidarsson, Nienke Oskam, Robbert M Spaapen, Oskam, N., April J Baral, Richard B Pouw, Vidarsson, Gestur   +45 more
core   +1 more source