Results 31 to 40 of about 135,986 (295)

Alternative complement pathway deregulation is correlated with dengue severity. [PDF]

PLoS ONE, 2009
BACKGROUND:The complement system, a key component that links the innate and adaptive immune responses, has three pathways: the classical, lectin, and alternative pathways. In the present study, we have analyzed the levels of various complement components
Eduardo J M Nascimento, Ana M Silva, Marli T Cordeiro, Carlos A Brito, Laura H V G Gil, Ulisses Braga-Neto, Ernesto T A Marques   +6 more
doaj   +1 more source

The Emerging Role of Complement Proteins as a Target for Therapy of IgA Nephropathy

Frontiers in Immunology, 2019
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is necessary for diagnosis, with routine immunofluorescence microscopy revealing dominant ...
Dana V. Rizk, Nicolas Maillard, Bruce A. Julian, Barbora Knoppova, Barbora Knoppova, Todd J. Green, Jan Novak, Robert J. Wyatt   +7 more
doaj   +1 more source

The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure

Frontiers in Immunology, 2021
ObjectiveDysregulation of the complement system has been described in patients with heart failure (HF). However, data on the alternative pathway are scarce and it is unknown if levels of factor B (FB) and the C3 convertase C3bBbP are elevated in these ...
Margrethe Flesvig Holt, Margrethe Flesvig Holt, Annika E. Michelsen, Annika E. Michelsen, Negar Shahini, Elisabeth Bjørkelund, Christina Holt Bendz, Richard J. Massey, Richard J. Massey, Camilla Schjalm, Bente Halvorsen, Bente Halvorsen, Kaspar Broch, Kaspar Broch, Thor Ueland, Thor Ueland, Thor Ueland, Lars Gullestad, Lars Gullestad, Lars Gullestad, Per H. Nilsson, Per H. Nilsson, Pål Aukrust, Pål Aukrust, Pål Aukrust, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Mieke C. Louwe   +29 more
doaj   +1 more source

Complement 1 Inhibitor Is a Regulator of the Alternative Complement Pathway [PDF]

The Journal of Experimental Medicine, 2001
We studied complement 1 inhibitor (C1-INH) as an inhibitor of the alternative complement pathway. C1-INH prevented lysis, induced by the alternative complement pathway, of paroxysmal nocturnal hemoglobinuria (PNH) erythrocytes in human serum. It inhibited the binding of both factors B and C3 to PNH and rabbit erythrocytes and blocked the ability of ...
H, Jiang, E, Wagner, H, Zhang, M M, Frank   +3 more
openaire   +2 more sources

C2 by-pass: cross-talk between the complement classical and alternative pathways

, 2022
Several disorders associated with the total or partial absence of components of the human complement system are known. Deficiencies of classical pathway (CP) components are generally linked to systemic lupus erythematosus (SLE) or SLE-like syndromes ...
Patel, H., Sim, R.B., Laich, A., Zarantonello, A., Inal, J.M.   +4 more
core   +1 more source

Low molecular weight polysialic acid binds to properdin and reduces the activity of the alternative complement pathway

Scientific Reports, 2022
Sialic acids as the terminal caps of the cellular glycocalyx play an essential role in self-recognition and were shown to modulate complement processes via interaction between α2,3-linked sialic acids and complement factor H. Previously, it was suggested
Anahita Shahraz, Yuchen Lin, Joshua Mbroh, Jonas Winkler, Huan Liao, Marie Lackmann, Annemarie Bungartz, Peter F. Zipfel, Christine Skerka, Harald Neumann   +9 more
doaj   +1 more source

Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]

, 2012
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Teresia Hallström, Peter F. Zipfel, Zipfel, Peter F, Christine Skerka, Hallström, Teresia, Kraiczy, Peter, Skerka, Christine, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Zipfel, Peter F., Reinhard Wallich, Peter Kraiczy, Stevenson, Brian, Brian Stevenson   +14 more
core   +1 more source

COMPLEMENT-MEDIATED ADIPOCYTE LYSIS BY NEPHRITIC FACTOR SERA

, 1993
Recent data indicate a previously unsuspected link between the complement system and adipocyte biology. Murine adipocytes produce key components of the alternative pathway of complement and are able to activate this pathway.
Lachmann, PJ, Peters, DK, P J Lachmann, D K Peters, P W Mathieson, Oliveira, DBG, R Würzner, D B Oliveria, Mathieson, PW, Würzner, R, Oliveria, DB   +10 more
core   +1 more source

Plasma Proteomic Analysis Reveals the Potential Role of Lectin and Alternative Complement Pathways in IgA Vasculitis Pathogenesis

Diagnostics, 2023
Background: IgA vasculitis (IgAV) is the most common form of childhood vasculitis. A better understanding of its pathophysiology is required to identify new potential biomarkers and treatment targets.
Selcan Demir, Idil Yet, Melis Sardan Ekiz, Erdal Sag, Yelda Bilginer, Omur Celikbicak, Incilay Lay, Seza Ozen   +7 more
doaj   +1 more source

Heme Interactions as Regulators of the Alternative Pathway Complement Responses and Implications for Heme-Associated Pathologies

Current Issues in Molecular Biology, 2023
Heme (Fe2+-protoporphyrin IX) is a pigment of life, and as a prosthetic group in several hemoproteins, it contributes to diverse critical cellular processes. While its intracellular levels are tightly regulated by networks of heme-binding proteins (HeBPs)
Stefanos A. Tsiftsoglou
doaj   +1 more source