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Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway [PDF]
Frontiers in Immunology, 2021 The complement system is central to first-line defense against invading pathogens. However, excessive complement activation and/or the loss of complement regulation contributes to the development of autoimmune diseases, systemic inflammation, and ...
Jonathan Barratt +2 more
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Alternative Complement Pathway Inhibition by Lampalizumab [PDF]
Ophthalmology Science, 2023 Purpose: Lampalizumab, an antigen-binding fragment of a humanized monoclonal antibody directed against complement factor D (CFD), is designed to treat geographic atrophy (GA) secondary to age-related macular degeneration.
Rose Edmonds, MS +3 more
doaj +3 more sources
Diagnosis of complement alternative pathway disorders [PDF]
Kidney International, 2016 Kidney diseases resulting from abnormal control of the complement alternative pathway include atypical hemolytic uremic syndrome, C3 glomerulonephritis, and dense-deposit disease, as well as atypical postinfectious glomerulonephritis. Although clinically diverse, they all result from loss of surface or fluid-phase complement control, caused by acquired
Andrea Angioï +2 more
exaly +5 more sources
Alternative Complement Pathway Inhibition Abrogates Pneumococcal Opsonophagocytosis in Vaccine-Naïve, but Not in Vaccinated Individuals [PDF]
Frontiers in Immunology, 2021 To assess the relative contribution of opsonisation by antibodies, classical and alternative complement pathways to pneumococcal phagocytosis, we analyzed killing of pneumococci by human blood leukocytes collected from vaccine-naïve and PCV13-vaccinated ...
Lukas Muri +10 more
doaj +3 more sources
Looking back on the alternative complement pathway [PDF]
Immunobiology, 2018 The alternative pathway of complement originated from the Properdin pathway originally described by the Pillemer laboratory in the 1950s. This work generated great controversy and it took several decades for a consensus on its components, its reaction sequence and its functions to emerge.
P J Lachmann
exaly +5 more sources
Quantitative Modeling of the Alternative Pathway of the Complement System. [PDF]
PLoS ONE, 2016 The complement system is an integral part of innate immunity that detects and eliminates invading pathogens through a cascade of reactions. The destructive effects of the complement activation on host cells are inhibited through versatile regulators that
Nehemiah Zewde +3 more
doaj +7 more sources
Low‐molecular weight inhibitors of the alternative complement pathway [PDF]
Immunological Reviews, 2023 Dysregulation of the alternative complement pathway predisposes individuals to a number of diseases. It can either be evoked by genetic alterations in or by stabilizing antibodies to important pathway components and typically leads to severe diseases ...
Anna Schubart +2 more
exaly +3 more sources
The alternative complement pathway revisited [PDF]
Journal of Cellular and Molecular Medicine, 2008 Introduction Methods to study and modify the alternative pathway Influence of AP amplification on the effect of specific activation of the other initial pathways Properdin Influence of AP in deficiency states Complement in sepsis Concluding remarks AbstractAlternative pathway amplification plays a major role for the final effect of initial specific ...
Tom Eirik Mollnes
exaly +3 more sources
DYSFUNCTION OF COMPLEMENT SYSTEM IN FAMILIAL MEDITERRANEAN FEVER
Медицинская иммунология, 2014 . During attacks of familial mediterranean fever (FMF), multiple systemic events are triggered, most of which promote autoinflammatory reactions. A molecular pattern of immune abnormalities in FMF is yet unclear.
G. M. Mkrtchyan +4 more
doaj +3 more sources
The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure [PDF]
Frontiers in Immunology, 2021 ObjectiveDysregulation of the complement system has been described in patients with heart failure (HF). However, data on the alternative pathway are scarce and it is unknown if levels of factor B (FB) and the C3 convertase C3bBbP are elevated in these ...
Margrethe Flesvig Holt +29 more
doaj +2 more sources