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Diagnosis of complement alternative pathway disorders [PDF]
Kidney International, 2016 Kidney diseases resulting from abnormal control of the complement alternative pathway include atypical hemolytic uremic syndrome, C3 glomerulonephritis, and dense-deposit disease, as well as atypical postinfectious glomerulonephritis. Although clinically diverse, they all result from loss of surface or fluid-phase complement control, caused by acquired
Andrea Angioi +2 more
exaly +5 more sources
Looking back on the alternative complement pathway [PDF]
Immunobiology, 2018 The alternative pathway of complement originated from the Properdin pathway originally described by the Pillemer laboratory in the 1950s. This work generated great controversy and it took several decades for a consensus on its components, its reaction sequence and its functions to emerge.
Peter Lachmann
exaly +6 more sources
Low-molecular weight inhibitors of the alternative complement pathway [PDF]
Immunological Reviews, 2023 Dysregulation of the alternative complement pathway predisposes individuals to a number of diseases. It can either be evoked by genetic alterations in or by stabilizing antibodies to important pathway components and typically leads to severe diseases ...
Joerg Eder, Tobias Junt, Stefanie Flohr
exaly +3 more sources
Quantitative Modeling of the Alternative Pathway of the Complement System. [PDF]
PLoS ONE, 2016 The complement system is an integral part of innate immunity that detects and eliminates invading pathogens through a cascade of reactions. The destructive effects of the complement activation on host cells are inhibited through versatile regulators that
Nehemiah Zewde +3 more
doaj +3 more sources
Complement-Mediated Kidney Diseases: Role of Alternative Pathway in Glomerular Inflammation
Kidney International ReportsComplement-mediated kidney diseases (CMKDs) comprise a diverse group of rare disorders characterized by the activation of the complement system, leading to glomerular inflammation, kidney injury, and in some cases, kidney failure.
Jonathan Barratt +4 more
doaj +2 more sources
Complement alternative pathway activation in human nonalcoholic steatohepatitis. [PDF]
PLoS ONE, 2014 The innate immune system plays a major role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Recently we reported complement activation in human NASH.
Filip M Segers +9 more
doaj +2 more sources
Autoantibodies against alternative complement pathway proteins in renal pathologies
Nefrología (English Edition), 2016 Complement system activation plays an important role in several renal pathologies, including antibody-mediated glomerulonephritis, ischaemia–reperfusion injury of transplanted kidneys or renal allograft rejection.
Pilar Nozal, Margarita López-Trascasa
doaj +2 more sources
Activation of the Alternative Complement Pathway by Fonsecaea pedrosoi [PDF]
Journal of Investigative Dermatology, 1984 Human sera were examined for evidence of complement activation by Fonsecaea pedrosoi. The serum that had been incubated with F. pedrosoi showed immunoelectrophoretic C3 conversion and generation of C5a, as measured by radioimmunoassay. C3 conversion and C5a generation did not occur in serum chelated with EDTA, or in serum heated to 56 degrees C for 30 ...
Torinuki, Wakio +3 more
openaire +3 more sources
Severe COVID-19 is associated with hyperactivation of the alternative complement pathway. [PDF]
J Allergy Clin Immunol, 2022 International audienceBackground: Severe coronavirus disease 2019 (COVID-19) is characterized by impaired type I interferon activity and a state of hyperinflammation leading to acute respiratory distress syndrome.
Boussier J +16 more
europepmc +2 more sources
Complement factor D is linked to platelet activation in human and rodent sepsis
Intensive Care Medicine Experimental, 2021 Background The complement factor D (CFD) exerts a regulatory role during infection. However, its physiological function in coagulopathy and its impact on the course of an infection remains unclear. Materials Wild-type and CFD-deficient mice (n = 91) were
O. Sommerfeld +6 more
doaj +1 more source