Results 11 to 20 of about 135,678 (188)

Low molecular weight polysialic acid binds to properdin and reduces the activity of the alternative complement pathway [PDF]

Scientific Reports, 2022
Sialic acids as the terminal caps of the cellular glycocalyx play an essential role in self-recognition and were shown to modulate complement processes via interaction between α2,3-linked sialic acids and complement factor H. Previously, it was suggested
Anahita Shahraz, Yuchen Lin, Joshua Mbroh, Jonas Winkler, Huan Liao, Marie Lackmann, Annemarie Bungartz, Peter F. Zipfel, Christine Skerka, Harald Neumann   +9 more
doaj   +2 more sources

PolySialic Acid Nanoparticles Actuate Complement-Factor-H-Mediated Inhibition of the Alternative Complement Pathway: A Safer Potential Therapy for Age-Related Macular Degeneration [PDF]

Pharmaceuticals
The alternative pathway of the complement system is implicated in the etiology of age-related macular degeneration (AMD). Complement depletion with pegcetacoplan and avacincaptad pegol are FDA-approved treatments for geographic atrophy in AMD that, while
Sheri L. Peterson, Anitha Krishnan, Diyan Patel, Ali Khanehzar, Amit Lad, Jutamas Shaughnessy, Sanjay Ram, David Callanan, Derek Kunimoto, Mohamed A. Genead, Michael J. Tolentino   +10 more
doaj   +2 more sources

Dengue virus and the complement alternative pathway [PDF]

FEBS Letters, 2020
Dengue disease is an inflammatory‐driven pathology, and complement overactivation is linked to disease severity and vascular leakage. Additionally, dysregulation of complement alternative pathway (AP) components has been described, such as upregulation of complement factor D and downregulation of complement factor H (FH), which activate and inhibit the
Jillian M Carr
exaly   +3 more sources

Complement-Mediated Kidney Diseases: Role of Alternative Pathway in Glomerular Inflammation

Kidney International Reports
Complement-mediated kidney diseases (CMKDs) comprise a diverse group of rare disorders characterized by the activation of the complement system, leading to glomerular inflammation, kidney injury, and in some cases, kidney failure.
Jonathan Barratt, Peter Garred, Richard A. Lafayette, Hong Zhang, Jürgen Floege   +4 more
doaj   +2 more sources

Complement alternative pathway activation in human nonalcoholic steatohepatitis. [PDF]

PLoS ONE, 2014
The innate immune system plays a major role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Recently we reported complement activation in human NASH.
Filip M Segers, Froukje J Verdam, Charlotte de Jonge, Bas Boonen, Ann Driessen, Ronit Shiri-Sverdlov, Nicole D Bouvy, Jan Willem M Greve, Wim A Buurman, Sander S Rensen   +9 more
doaj   +2 more sources

Alternative Complement Pathway in Carotid Atherosclerosis: Low Plasma Properdin Levels Associate With Long‐Term Cardiovascular Mortality [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in ...
Mieke C. Louwe, Chrysostomi Gialeli, Annika E. Michelsen, Sverre Holm, Andreas Edsfeldt, Karolina Skagen, Tove Lekva, Maria Belland Olsen, Vigdis Bjerkeli, Therese Schjørlien, Kristine Stø, Xiang Yi Kong, Tuva B. Dahl, Per H. Nilsson, Peter Libby, Pål Aukrust, Tom Eirik Mollnes, Thor Ueland, Mona Skjelland, Isabel Gonçalves, Bente Halvorsen   +20 more
doaj   +2 more sources

Autoantibodies against alternative complement pathway proteins in renal pathologies

Nefrología (English Edition), 2016
Complement system activation plays an important role in several renal pathologies, including antibody-mediated glomerulonephritis, ischaemia–reperfusion injury of transplanted kidneys or renal allograft rejection.
Pilar Nozal, Margarita López-Trascasa
doaj   +2 more sources

Activation of the Alternative Complement Pathway by Fonsecaea pedrosoi

Journal of Investigative Dermatology, 1984
Human sera were examined for evidence of complement activation by Fonsecaea pedrosoi. The serum that had been incubated with F. pedrosoi showed immunoelectrophoretic C3 conversion and generation of C5a, as measured by radioimmunoassay. C3 conversion and C5a generation did not occur in serum chelated with EDTA, or in serum heated to 56 degrees C for 30 ...
Torinuki, Wakio, Okohchi, Kyoko, Takematsu, Hideaki, Tagami, Hachiro   +3 more
openaire   +3 more sources

Severe COVID-19 is associated with hyperactivation of the alternative complement pathway. [PDF]

J Allergy Clin Immunol, 2022
International audienceBackground: Severe coronavirus disease 2019 (COVID-19) is characterized by impaired type I interferon activity and a state of hyperinflammation leading to acute respiratory distress syndrome.
Boussier J, Yatim N, Marchal A, Hadjadj J, Charbit B, El Sissy C, Carlier N, Pène F, Mouthon L, Tharaux PL, Bergeron A, Smadja DM, Rieux-Laucat F, Duffy D, Kernéis S, Frémeaux-Bacchi V, Terrier B.   +16 more
europepmc   +2 more sources

Mutations in the alternative complement pathway in multiple myeloma patients with carfilzomib-induced thrombotic microangiopathy. [PDF]

Blood Cancer J, 2023
Thrombotic microangiopathy (TMA) has been reported to occur in multiple myeloma (MM) patients in association with treatment with carfilzomib, an irreversible proteasome inhibitor (PI).
Moscvin M, Liacos CI, Chen T, Theodorakakou F, Fotiou D, Hossain S, Rowell S, Leblebjian H, Regan E, Czarnecki P, Bagnoli F, Bolli N, Richardson P, Rennke HG, Dimopoulos MA, Kastritis E, Bianchi G.   +16 more
europepmc   +2 more sources