Results 21 to 30 of about 135,678 (188)

Blocking the alternative complement pathway [PDF]

Nature Reviews Drug Discovery, 2016
Sarah Crunkhorn
exaly   +2 more sources

Complement factor D is linked to platelet activation in human and rodent sepsis

Intensive Care Medicine Experimental, 2021
Background The complement factor D (CFD) exerts a regulatory role during infection. However, its physiological function in coagulopathy and its impact on the course of an infection remains unclear. Materials Wild-type and CFD-deficient mice (n = 91) were
O. Sommerfeld, K. Dahlke, M. Sossdorf, R. A. Claus, A. Scherag, M. Bauer, F. Bloos   +6 more
doaj   +1 more source

The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases

Frontiers in Immunology, 2021
The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu, Shaopeiwen Luo, Stefanie A. Ma, Priyanka Saminathan, Herman Li, Jenny M. Gunnersen, Harris A. Gelbard, Jennetta W. Hammond   +7 more
doaj   +1 more source

Preanalytical classical and alternative complement pathway activity loss. [PDF]

Biochem Med (Zagreb), 2019
Introduction: Complement functional analyses provide insight into the integrity of the entire complement reaction cascade. These tests are suitable for investigating suspected complement deficiencies.
Vercauteren KOA, Lambrecht S, Delanghe J.   +2 more
europepmc   +2 more sources

Complement Alternative and Mannose-Binding Lectin Pathway Activation Is Associated With COVID-19 Mortality

Frontiers in Immunology, 2021
BackgroundThe SARS-CoV-2 infection triggers excessive immune response resulting in increased levels of pro-inflammatory cytokines, endothelial injury, and intravascular coagulopathy.
Federica Defendi, Corentin Leroy, Corentin Leroy, Olivier Epaulard, Olivier Epaulard, Giovanna Clavarino, Antoine Vilotitch, Marion Le Marechal, Marie-Christine Jacob, Tatiana Raskovalova, Martine Pernollet, Audrey Le Gouellec, Audrey Le Gouellec, Jean-Luc Bosson, Pascal Poignard, Pascal Poignard, Matthieu Roustit, Matthieu Roustit, Nicole Thielens, Chantal Dumestre-Pérard, Chantal Dumestre-Pérard, Jean-Yves Cesbron   +21 more
doaj   +1 more source

The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation [PDF]

, 2023
OBJECTIVES: The complement system is an important component of innate immunity. The alternative pathway (AP) amplification loop is considered an essential feed forward mechanism for complement activation. However, the role of the AP in classical pathway (
Zeerleder, S., Mieke C Brouwer, Thielen, A.J., Spaapen, Robbert M, Boer, E.C. de, Rispens, Theo, Jongerius, Ilse, Ilse Jongerius, Spaapen, R.M., Rispens, T., Brouwer, Mieke C, Langereis, J.D., Angela Kamp, Esther CW deBoer, Langereis, Jeroen D, Marlieke L Jongsma, Diana Wouters, Kamp, Angela, Jongsma, Marlieke L, Pouw, Richard B, Theo Rispens, Kamp, A., Jongerius, I., Thielen, Astrid JF, Wouters, D., Baral, A.J., Sacha Zeerleder, Pouw, R.B., de Boer, Esther CW, Oskam, Nienke, Jongsma, Marlieke L., Jeroen D Langereis, Astrid JF Thielen, Brouwer, M.C.T., Baral, April J, Vidarsson, G., Esther CW de Boer, Zeerleder, Sacha, Wouters, Diana, Gestur Vidarsson, Nienke Oskam, Robbert M Spaapen, Oskam, N., April J Baral, Richard B Pouw, Vidarsson, Gestur   +45 more
core   +1 more source

The Complement System and ANCA Associated Vasculitis in the Era of Anti-Complement Drugs

Frontiers in Immunology, 2022
ANCA (anti-neutrophil cytoplasmic antibody)-associated vasculitis (AAV) is the condition in which ANCA, as an autoantibody, is associated with the pathogenesis of vasculitis in small blood vessels, mainly in the ear, nose, throat, kidney, lung, and ...
Yasutaka Kimoto, Takahiko Horiuchi
doaj   +1 more source

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Kouser, L, Cordula M. Stover, Munirah Abdul-Aziz, Robert B. Sim, Nayak, A, Lubna Kouser, L. Kouser (7639589), Kishore, U, M. Abdul-Aziz (7677725), R. B. Sim (7584038), U. Kishore (7639601), Cordula M. Stover (7117046), Abdul-Aziz, M, Annapurna Nayak, A. Nayak (7334981), Stover, CM, Sim, RB, Uday Kishore   +17 more
core   +1 more source

Be on Target: Strategies of Targeting Alternative and Lectin Pathway Components in Complement-Mediated Diseases

Frontiers in Immunology, 2018
The complement system has moved into the focus of drug development efforts in the last decade, since its inappropriate or uncontrolled activation has been recognized in many diseases.
József Dobó, Andrea Kocsis, Péter Gál   +2 more
doaj   +1 more source

Complement activation and protein adsorption by carbon nanotubes [PDF]

, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel, Sim, Robert B., Sloan, Jeremy, Green, Malcolm L.H., Sim, Edith, Salvador-Morales, Carolina, Green, Malcolm L. H.   +6 more
core   +1 more source