Results 31 to 40 of about 343,249 (291)
Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis [PDF]
Kidney Research and Clinical Practice, 2023 Background Alternative complement pathway dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and ...
Jiwon Ryu +14 more
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Quantitative Modeling of the Alternative Pathway of the Complement System. [PDF]
PLoS ONE, 2016 The complement system is an integral part of innate immunity that detects and eliminates invading pathogens through a cascade of reactions. The destructive effects of the complement activation on host cells are inhibited through versatile regulators that
Nehemiah Zewde +3 more
doaj +1 more source
Mathematical Modelling of Alternative Pathway of Complement System [PDF]
Bulletin of Mathematical Biology, 2020 AbstractThe complement system (CS) is an integral part of innate immunity and can be activated via three different pathways. The alternative pathway (AP) has a central role in the function of the CS. The AP of complement system is implicated in several human disease pathologies.
Suruchi Bakshi +10 more
openaire +2 more sources
Frontiers in Immunology, 2015 The complement system is a major constituent of the innate immune system. It not only bridges innate and adaptive arms of the immune system but also links the immune system with the coagulation system.
Hany Ibrahim Kenawy +2 more
doaj +1 more source
Frontiers in Immunology, 2022 ObjectiveThe pathogenesis of thrombotic microangiopathy (TMA) in lupus nephritis (LN) remains complicated. This study aimed to detect the deposition of complement lectin pathway (LP) and alternative pathway (AP) components in renal tissues, then evaluate
Binshan Zhang, Guolan Xing
doaj +1 more source
Human complement factor H. Two factor H proteins are derived from alternatively spliced transcripts [PDF]
, 1991 The human complement factor H is an important component in the control of the alternative pathway of complement activation. We have previously shown that at least three factor H homologous mRNA species of 4.3 kb, 1.8 kb and 1.4 kb in length are ...
Alsenz +23 more
core +1 more source
Alternative complement pathway deregulation is correlated with dengue severity. [PDF]
PLoS ONE, 2009 BACKGROUND:The complement system, a key component that links the innate and adaptive immune responses, has three pathways: the classical, lectin, and alternative pathways. In the present study, we have analyzed the levels of various complement components
Eduardo J M Nascimento +6 more
doaj +1 more source
The Emerging Role of Complement Proteins as a Target for Therapy of IgA Nephropathy
Frontiers in Immunology, 2019 IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is necessary for diagnosis, with routine immunofluorescence microscopy revealing dominant ...
Dana V. Rizk +7 more
doaj +1 more source
Mannose binding lectin is required for alphavirus-induced arthritis/myositis [PDF]
, 2015 Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis.
Blevins, Lance K. +10 more
core +1 more source
Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease [PDF]
, 2011 Background Complement proteins and activation products have been found associated with neuropathology in Alzheimer's disease (AD). Recently, a C5a receptor antagonist was shown to suppress neuropathology in two murine models of AD, Tg2576 and
Maria I Fonseca +6 more
core +2 more sources