Results 51 to 60 of about 135,678 (188)
Frontiers in Immunology, 2023 Properdin acts as an essential positive regulator of the alternative pathway of complement by stabilizing enzymatic convertases. Identical properdin monomers form head-to-tail associations of oligomers in a reported 20:54:26 ratio (most often described ...
Sara R. Moore +5 more
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Activation of the Alternative Complement Pathway by Fungal Melanins [PDF]
Clinical and Vaccine Immunology, 2002 ABSTRACTMelanins are complex biological pigments formed by the oxidative polymerization of phenolic and/or indolic compounds. These pigments have been implicated in the pathogenesis of some microbial infections, malignancies, degenerative disorders, and autoimmune diseases.
A L, Rosas +4 more
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Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae [PDF]
, 2007 The physiological functions of the acute phase protein serum amyloid P (SAP) component are not well defined, although they are likely to be important, as no natural state of SAP deficiency has been reported.
Brown, JS +7 more
core
PLoS Pathogens, 2019 Ecotin is a serine protease inhibitor produced by hundreds of microbial species, including pathogens. Here we show, that ecotin orthologs from Escherichia coli, Yersinia pestis, Pseudomonas aeruginosa and Leishmania major are potent inhibitors of MASP-1 ...
Zoltán Attila Nagy +10 more
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Activation of the alternative complement pathway by Sporothrix schenckii [PDF]
Infection and Immunity, 1986 We studied the activation of complement by Sporothrix schenckii yeast cells. Total complement activity, and the effect of various activators on this activity, were assayed on aliquots of fresh nonimmune human serum with and without prior treatment with chelators.
E N, Scott, H G, Muchmore, D P, Fine
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Bloqueo del complemento: promesas terapéuticas y retos pendientes en la práctica clínica
NefrologíaResumen: La comprensión del complemento en las glomerulopatías ha avanzado notablemente, mostrando que este sistema, más allá de la inmunidad innata, es un mediador clave del daño renal en un amplio espectro de nefropatías, desde las mediadas por ...
Gema Fernández-Juárez +9 more
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Components of the alternative complement pathway in patients with psoriasis
Acta Dermatovenerologica Alpina Pannonica et Adriatica, 2017 Psoriasis is a chronic inflammatory skin disease. Adipose tissue plays important roles in the events that regulate body metabolism. This study determined the levels of complement 3 ( C3), acylation-stimulating protein (ASP), and adipsin, which take part in the alternate complement pathway, and are synthesized in and secreted by adipose tissue.Thirty ...
Bugdayci, Guler, Sereflican, Betul
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Methylprednisolone inhibits the alternative and amplification pathways of complement [PDF]
Infection and Immunity, 1982 Methylprednisolone sodium succinate limited the ability of zymosan or lipopolysaccharide to activate complement in normal serum by the alternative amplification pathways. Methylprednisolone limited B consumption in a reaction mixture which contained purified C3b, D, and B, indicating that soluble steroid directly inhibited the amplification pathway ...
J M, Weiler, B D, Packard
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Blockade of Alternative Complement Pathway in Dense Deposit Disease
Case Reports in Nephrology, 2014 A patient aged 17 with dense deposit disease associated with complement activation, circulating C3 Nef, and Factor H mutation presented with nephrotic syndrome and hypertension.
Aurore Berthe-Aucejo +6 more
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Haematologica, 2017 Paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome are diseases of excess activation of the alternative pathway of complement that are treated with eculizumab, a humanized monoclonal antibody against the terminal complement ...
Xuan Yuan +8 more
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