Results 11 to 20 of about 1,857,462 (287)
The Complement System in Kidney Transplantation
Cells, 2023 Kidney transplantation is the therapy of choice for patients who suffer from end-stage renal diseases. Despite improvements in surgical techniques and immunosuppressive treatments, long-term graft survival remains a challenge.
Donata Santarsiero, Sistiana Aiello
doaj +1 more source
Current Biology, 1998 Work in the authors' laboratories is supported by grants from the Arthritis and Rheumatism Council and the Wellcome Trust.
Taylor, Philip +2 more
openaire +2 more sources
Antimicrobial Peptide Arenicin-1 Derivative Ar-1-(C/A) as Complement System Modulator
Marine Drugs, 2020 Antimicrobial peptides (AMPs) are not only cytotoxic towards host pathogens or cancer cells but also are able to act as immunomodulators. It was shown that some human and non-human AMPs can interact with complement proteins and thereby modulate ...
Ilia A. Krenev +11 more
doaj +1 more source
Proprotein Convertases and the Complement System
Frontiers in Immunology, 2022 Proteins destined for secretion - after removal of the signal sequence - often undergo further proteolytic processing by proprotein convertases (PCs).
József Dobó +3 more
doaj +1 more source
The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host’s Complement System
Biomolecules, 2022 The complement system exerts crucial functions both in innate immune responses and adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen invasions including protozoan parasites.
Sajad Rashidi +5 more
doaj +1 more source
The complement system and autoimmune diseases
Chronic Diseases and Translational Medicine, 2022 The complement system plays a key role in the pathogenesis of autoimmune diseases, which usually injures the kidney. More and more studies have shown the pathogenic role and indicated that abnormal activation of the complement system was highly involved ...
Changhao Jia, Ying Tan, Minghui Zhao
doaj +1 more source
Cell and Tissue Research, 2010 The complement system consists of a tightly regulated network of proteins that play an important role in host defense and inflammation. Complement activation results in opsonization of pathogens and their removal by phagocytes, as well as cell lysis.
Sarma, J. Vidya, Ward, Peter A.
openaire +3 more sources
Quantitative multiplex profiling of the complement system to diagnose complement‐mediated diseases
Clinical & Translational Immunology, 2020 Objectives Complement deficiencies are difficult to diagnose because of the variability of symptoms and the complexity of the diagnostic process. Here, we applied a novel ‘complementomics’ approach to study the impact of various complement deficiencies ...
Esther Willems +23 more
doaj +1 more source
Respiratory Research, 2022 Background The efficacy and safety of complement inhibition in COVID-19 patients is unclear. Methods A multicenter randomized controlled, open-label trial.
Elisabeth De Leeuw +27 more
doaj +1 more source
Complement System in Alzheimer’s Disease [PDF]
International Journal of Molecular Sciences, 2021 Alzheimer’s disease is a type of dementia characterized by problems with short-term memory, cognition, and difficulties with activities of daily living. It is a progressive, neurodegenerative disorder. The complement system is an ancient part of the innate immune system and comprises of more than thirty serum and membrane-bound proteins.
Akash Shah +2 more
openaire +3 more sources