Clinical Images: Anti‐MDA5 dermatomyositis with rapidly progressive interstitial lung disease presenting with rapidly progressive glomerulonephritis due to C3 glomerulopathy [PDF]
ACR Open RheumatolACR Open Rheumatology, Volume 8, Issue 4, April 2026.
Lebhar J +6 more
europepmc +2 more sources
Eculizumab in C3 Glomerulopathy: A Systematic Review of Therapeutic Efficacy and Clinical Outcomes [PDF]
PharmaceuticsBackground: C3 glomerulopathies (C3G), including dense deposit disease (DDD) and C3 glomerulonephritis (C3GN), are rare kidney disorders driven by dysregulation of the alternative complement pathway.
Dominik Lewandowski +6 more
doaj +2 more sources
C3 Glomerulopathy Diagnosis, Current Treatments, and Emerging Therapies [PDF]
Kidney MedicineC3 glomerulopathy (C3G) is characterized by prominent deposition of complement component C3 in the kidney glomeruli, leading to glomerular inflammation.
Mahtab Mashayekhi +10 more
doaj +2 more sources
C3 Glomerulopathy: Novel Treatment Paradigms [PDF]
Kidney International ReportsC3 glomerulopathy (C3G) is diagnosed by kidney biopsy, with immunofluorescence showing isolated or dominant C3 staining, indicating hyperactivity of the alternative complement pathway as the key driver of glomerular injury.
Blanca Tarragon Estebanez +1 more
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Pregnancy outcomes in C3 glomerulopathy: a retrospective review [PDF]
BMC NephrologyBackground C3 Glomerulopathy (C3G) is an ultra-rare glomerular disease driven by dysregulation of the alternative pathway of complement. 30–50% of adult patients progress to end stage kidney disease (ESKD) within 10 years of diagnosis. Little is known of
Lauren O. Fergus +9 more
doaj +2 more sources
C3 glomerulopathy is highly prevalent in French Polynesia [PDF]
Journal of Translational AutoimmunityObjective: To compare the natural history of C3 glomerulopathy (C3G) to acute post-infectious glomerulonephritis (APIGN) in a cohort of patients with a relative homogeneity of environment conditions and genetic background.
Nelly Candela +9 more
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Clinical characteristics and short term outcomes of childhood immune complex membranoproliferative glomerulonephritis and C3 glomerulopathy: a single centre retrospective study [PDF]
BMC NephrologyBackground Membranoproliferative glomerulonephritis, with its immune complex variety and C3 glomerulopathy, is a rare glomerular disease in children. The objective of this study was to determine the clinical features and short-term outcomes in children ...
Irshad Ali Bajeer +5 more
doaj +2 more sources
Pathology of C3 Glomerulopathy [PDF]
Childhood Kidney Diseases, 2019 C3 glomerulopathy is a renal disorder involving dysregulation of alternative pathway complement activation. In most instances, a membranoproliferative pattern of glomerular injury with a prevalence of C3 deposition is observed by immunofluorescence ...
Su-Jin Shin, Yoonje Seong, Beom Jin Lim
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Unraveling the Role of Allo-Antibodies and Transplant Injury. [PDF]
, 2016 Alloimmunity driving rejection in the context of solid organ transplantation can be grossly divided into mechanisms predominantly driven by either T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR), though the co-existence of both ...
Matsuda, Yoshiko, Sarwal, Minnie M
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Heterozygous laminin β2 mutation in C3 glomerulopathy
Saudi Journal of Kidney Diseases and Transplantation, 2021 C3 glomerulopathy is usually seen with the presence of C3 nephritic factor, homozygous or heterozygous mutations in the regulatory complement proteins factor H, factor I, or C3. We describe the presence of heterozygous laminin β2 mutation in a patient of
Manish R Balwani +3 more
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