Results 1 to 10 of about 4,312 (134)

Clinical Images: Anti-MDA5 dermatomyositis with rapidly progressive interstitial lung disease presenting with rapidly progressive glomerulonephritis due to C3 glomerulopathy. [PDF]

ACR Open Rheumatol
ACR Open Rheumatology, Volume 8, Issue 4, April 2026.
Lebhar J, Kellogg B, Herndon S, Sims CA, Maheswaranathan M, Howell D, Optican R.   +6 more
europepmc   +2 more sources

Eculizumab in C3 Glomerulopathy: A Systematic Review of Therapeutic Efficacy and Clinical Outcomes [PDF]

Pharmaceutics
Background: C3 glomerulopathies (C3G), including dense deposit disease (DDD) and C3 glomerulonephritis (C3GN), are rare kidney disorders driven by dysregulation of the alternative complement pathway.
Dominik Lewandowski, Mateusz Konieczny, Krzysztof Chrzanowski, Marta Jakubowska, Zuzanna Paryzek, Miłosz Miedziaszczyk, Ilona Idasiak-Piechocka   +6 more
doaj   +2 more sources

C3 Glomerulopathy Diagnosis, Current Treatments, and Emerging Therapies [PDF]

Kidney Medicine
C3 glomerulopathy (C3G) is characterized by prominent deposition of complement component C3 in the kidney glomeruli, leading to glomerular inflammation.
Mahtab Mashayekhi, Jonathan E. Zuckerman, Jonathan Barratt, Richard J. Glassock, Fernando Caravaca-Fontán, Raymond K. Hsu, Arun Rajasekaran, Edgar Lerma, Sahibzadi Mahrukh Noor, Amir Abdipour, Sayna Norouzi   +10 more
doaj   +2 more sources

Pregnancy outcomes in C3 glomerulopathy: a retrospective review [PDF]

BMC Nephrology
Background C3 Glomerulopathy (C3G) is an ultra-rare glomerular disease driven by dysregulation of the alternative pathway of complement. 30–50% of adult patients progress to end stage kidney disease (ESKD) within 10 years of diagnosis. Little is known of
Lauren O. Fergus, Meryl Waldman, Monica D. Hall, Lynn Vining, Jillian Hall, Tina Liu, Yuzhou Zhang, Patrick J. Walker, Richard J. H. Smith, Carla M. Nester   +9 more
doaj   +2 more sources

C3 glomerulopathy is highly prevalent in French Polynesia [PDF]

Journal of Translational Autoimmunity
Objective: To compare the natural history of C3 glomerulopathy (C3G) to acute post-infectious glomerulonephritis (APIGN) in a cohort of patients with a relative homogeneity of environment conditions and genetic background.
Nelly Candela, Nicolas Benichou, Mathilde Lefebvre, Lorraine Gueguen, Paula Vieira-Martins, Carine El Sissy, Hervé Sartelet, Pascale Testevuide, Ronan Delaval, Stanislas Faguer   +9 more
doaj   +2 more sources

Pathology of C3 Glomerulopathy [PDF]

Childhood Kidney Diseases, 2019
C3 glomerulopathy is a renal disorder involving dysregulation of alternative pathway complement activation. In most instances, a membranoproliferative pattern of glomerular injury with a prevalence of C3 deposition is observed by immunofluorescence ...
Su-Jin Shin, Yoonje Seong, Beom Jin Lim
doaj   +1 more source

Heterozygous laminin β2 mutation in C3 glomerulopathy

Saudi Journal of Kidney Diseases and Transplantation, 2021
C3 glomerulopathy is usually seen with the presence of C3 nephritic factor, homozygous or heterozygous mutations in the regulatory complement proteins factor H, factor I, or C3. We describe the presence of heterozygous laminin β2 mutation in a patient of
Manish R Balwani, Amit S Pasari, Amol R Bhawane, Priyanka R Tolani   +3 more
doaj   +1 more source

Diagnostic Problems in C3 Glomerulopathy

Biomedicines, 2023
Background: C3 glomerulopathies (C3GN) are a group of rare kidney diseases associated with impaired complement regulation. The effects of this disease include the accumulation of complement C3 in the kidneys. Based on the clinical data, as well as light,
Leszek Niepolski, Anna Czekała, Monika Seget-Dubaniewicz, Magdalena Frydrychowicz, Patrycja Talarska-Markiewicz, Angelika Kowalska, Jagoda Szmelter, Wiesława Salwa-Żurawska, Tomasz Sirek, Dawid Sobański, Beniamin Oskar Grabarek, Jakub Żurawski   +11 more
doaj   +1 more source

C3 glomerulopathy associated with both hypertensive retinopathy and purtscher-like retinopathy

American Journal of Ophthalmology Case Reports, 2022
Purpose: This article reports the case of a 21-year-old woman with both hypertensive retinopathy and Purtscher-like retinopathy in association with C3 glomerulopathy.
Moosa Zaidi, Kapil Mishra, Huy Vu Nguyen, Paul Peter Miller, Hashem Ghoraba, Irmak Karaca, Wataru Matsumiya, Quan Dong Nguyen, Loh-Shan Bryan Leung   +8 more
doaj   +1 more source

Favorable effect of bortezomib in dense deposit disease associated with monoclonal gammopathy: a case report

BMC Nephrology, 2018
Background Complement component 3 (C3) glomerulopathy, which includes dense deposit disease (DDD) and C3 glomerulonephritis, is caused by dysregulation of the alternative complement pathway.
Shuma Hirashio, Ayaka Satoh, Takahiro Arima, Kouichi Mandai, Tadasuke Awaya, Kumi Oshima, Shigeo Hara, Takao Masaki   +7 more
doaj   +1 more source