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C3 glomerulopathy [version 1; referees: 4 approved] [PDF]

F1000Research, 2017
C3 glomerulopathy is a recently defined entity that encompasses a group of kidney diseases caused by abnormal control of complement activation with deposition of complement component C3 in glomeruli leading to variable glomerular inflammation. Before the
H. Terence Cook
doaj   +6 more sources

Pathology of C3 Glomerulopathy [PDF]

Childhood Kidney Diseases, 2019
C3 glomerulopathy is a renal disorder involving dysregulation of alternative pathway complement activation. In most instances, a membranoproliferative pattern of glomerular injury with a prevalence of C3 deposition is observed by immunofluorescence ...
Su-Jin Shin, Yoonje Seong, Beom Jin Lim
doaj   +7 more sources

Diagnostic Problems in C3 Glomerulopathy

Biomedicines, 2023
Background: C3 glomerulopathies (C3GN) are a group of rare kidney diseases associated with impaired complement regulation. The effects of this disease include the accumulation of complement C3 in the kidneys. Based on the clinical data, as well as light,
Leszek Niepolski, Anna Czekała, Monika Seget-Dubaniewicz, Magdalena Frydrychowicz, Patrycja Talarska-Markiewicz, Angelika Kowalska, Jagoda Szmelter, Wiesława Salwa-Żurawska, Tomasz Sirek, Dawid Sobański, Beniamin Oskar Grabarek, Jakub Żurawski   +11 more
doaj   +4 more sources

Acquired drivers of C3 glomerulopathy. [PDF]

Clin Kidney J
C3 glomerulopathy (C3G) is a group of heterogeneous ultrarare kidney diseases characterized by dysregulated activation of the complement alternative pathway (AP) leading to excessive C3 cleavage.
Welsh SJ, Zhang Y, Smith RJH.
europepmc   +4 more sources

Pregnancy outcomes in C3 glomerulopathy: a retrospective review [PDF]

BMC Nephrology
Background C3 Glomerulopathy (C3G) is an ultra-rare glomerular disease driven by dysregulation of the alternative pathway of complement. 30–50% of adult patients progress to end stage kidney disease (ESKD) within 10 years of diagnosis. Little is known of
Lauren O. Fergus, Meryl Waldman, Monica D. Hall, Lynn Vining, Jillian Hall, Tina Liu, Yuzhou Zhang, Patrick J. Walker, Richard J. H. Smith, Carla M. Nester   +9 more
doaj   +3 more sources

Clinical characteristics and short term outcomes of childhood immune complex membranoproliferative glomerulonephritis and C3 glomerulopathy: a single centre retrospective study [PDF]

BMC Nephrology
Background Membranoproliferative glomerulonephritis, with its immune complex variety and C3 glomerulopathy, is a rare glomerular disease in children. The objective of this study was to determine the clinical features and short-term outcomes in children ...
Irshad Ali Bajeer, Sabeeta Khatri, Pawan Kumar, Seema Hashmi, Mohammed Mubarak, Ali Asghar Lanewala   +5 more
doaj   +3 more sources

Updates on C3 Glomerulopathy in Kidney Transplantation: Pathogenesis and Treatment Options [PDF]

Int J Mol Sci
C3 glomerulopathy is a rare disease, characterized by an abnormal activation of the complement’s alternative pathway that leads to the accumulation of the C3 component in the kidney.
Bartoli G, Dello Strologo A, Grandaliano G, Pesce F.   +3 more
europepmc   +3 more sources

Iptacopan Reduces Proteinuria and Stabilizes Kidney Function in C3 Glomerulopathy [PDF]

Kidney Int Rep
C3 glomerulopathy; Iptacopan; TransplantationGlomerulopatia C3; Iptacopan; TrasplantamentGlomerulopatía C3; Iptacopan; TrasplanteIntroduction C3 glomerulopathy (C3G) is a complex, chronic, ultra rare, progressive primary glomerulonephritis, resulting ...
Nester C, Eisenberger U, Karras A, le Quintrec M, Lightstone L, Praga M, Remuzzi G, Soler M, Liu J, Meier M, Tawfik R, Junge G, Biondani A, Trapani A, Webb N, Wong E.   +15 more
europepmc   +3 more sources

An Interdisciplinary Diagnostic Approach to Guide Therapy in C3 Glomerulopathy [PDF]

Frontiers in Immunology, 2022
Since the re-classification of membranoproliferative glomerulonephritis the new disease entity C3 glomerulopathy is diagnosed if C3 deposition is clearly dominant over immunoglobulins in immunohistochemistry or immunofluorescence.
Tilman Schmidt, Sara Afonso, Luce Perie, Karin Heidenreich, Sonia Wulf, Christian F. Krebs, Christian F. Krebs, Peter F. Zipfel, Peter F. Zipfel, Thorsten Wiech   +9 more
doaj   +2 more sources

Kidney transplant in patients with C3 glomerulopathy. [PDF]

Clin Kidney J
Complement protein 3 (C3) glomerulopathy (C3G) is a rare and progressive kidney disease primarily affecting young individuals and frequently advancing to end-stage kidney disease (ESKD).
Attieh RM, Bharati J, Sharma P, Nair G, Ayehu G, Jhaveri KD.   +5 more
europepmc   +2 more sources