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Pathology of C3 Glomerulopathy [PDF]

Childhood Kidney Diseases, 2019
C3 glomerulopathy is a renal disorder involving dysregulation of alternative pathway complement activation. In most instances, a membranoproliferative pattern of glomerular injury with a prevalence of C3 deposition is observed by immunofluorescence ...
Su-Jin Shin, Yoonje Seong, Beom Jin Lim
doaj   +8 more sources

Diagnostic Problems in C3 Glomerulopathy

Biomedicines, 2023
Background: C3 glomerulopathies (C3GN) are a group of rare kidney diseases associated with impaired complement regulation. The effects of this disease include the accumulation of complement C3 in the kidneys. Based on the clinical data, as well as light,
Leszek Niepolski, Anna Czekała, Monika Seget-Dubaniewicz, Magdalena Frydrychowicz, Patrycja Talarska-Markiewicz, Angelika Kowalska, Jagoda Szmelter, Wiesława Salwa-Żurawska, Tomasz Sirek, Dawid Sobański, Beniamin Oskar Grabarek, Jakub Żurawski   +11 more
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Remissions and progression of C3 glomerulopathy

Терапевтический архив, 2022
Aim. To analyze the outcomes of C3-glomerulopathy (C3-GP) and determine the associated factors. Materials and methods. A retrospective single-center study included 60 patients with newly diagnosed C3-GP (with primary C3-GP pC3-GP 82%). Of these, 48 (
Anna V. Karunnaya, Vladimir A. Dobronravov   +1 more
doaj   +3 more sources

C3 Glomerulopathy Diagnosis, Current Treatments, and Emerging Therapies. [PDF]

Kidney Med
C3 glomerulopathy (C3G) is characterized by prominent deposition of complement component C3 in the kidney glomeruli, leading to glomerular inflammation.
Mashayekhi M, Zuckerman JE, Barratt J, Glassock RJ, Caravaca-Fontán F, Hsu RK, Rajasekaran A, Lerma E, Noor SM, Abdipour A, Norouzi S.   +10 more
europepmc   +2 more sources

Eculizumab in C3 Glomerulopathy: A Systematic Review of Therapeutic Efficacy and Clinical Outcomes. [PDF]

Pharmaceutics
Background: C3 glomerulopathies (C3G), including dense deposit disease (DDD) and C3 glomerulonephritis (C3GN), are rare kidney disorders driven by dysregulation of the alternative complement pathway.
Lewandowski D, Konieczny M, Chrzanowski K, Jakubowska M, Paryzek Z, Miedziaszczyk M, Idasiak-Piechocka I.   +6 more
europepmc   +2 more sources

Pregnancy outcomes in C3 glomerulopathy: a retrospective review. [PDF]

BMC Nephrol
Background C3 Glomerulopathy (C3G) is an ultra-rare glomerular disease driven by dysregulation of the alternative pathway of complement. 30–50% of adult patients progress to end stage kidney disease (ESKD) within 10 years of diagnosis. Little is known of
Fergus LO, Waldman M, Hall MD, Vining L, Hall J, Liu T, Zhang Y, Walker PJ, Smith RJH, Nester CM.   +9 more
europepmc   +2 more sources

C3 glomerulopathy is highly prevalent in French Polynesia. [PDF]

J Transl Autoimmun
Objective: To compare the natural history of C3 glomerulopathy (C3G) to acute post-infectious glomerulonephritis (APIGN) in a cohort of patients with a relative homogeneity of environment conditions and genetic background.
Candela N, Benichou N, Lefebvre M, Gueguen L, Vieira-Martins P, El Sissy C, Sartelet H, Testevuide P, Delaval R, Faguer S.   +9 more
europepmc   +2 more sources

Heterozygous laminin β2 mutation in C3 glomerulopathy

Saudi Journal of Kidney Diseases and Transplantation, 2021
C3 glomerulopathy is usually seen with the presence of C3 nephritic factor, homozygous or heterozygous mutations in the regulatory complement proteins factor H, factor I, or C3. We describe the presence of heterozygous laminin β2 mutation in a patient of
Manish R Balwani, Amit S Pasari, Amol R Bhawane, Priyanka R Tolani   +3 more
doaj   +1 more source

C3 glomerulopathy associated with both hypertensive retinopathy and purtscher-like retinopathy

American Journal of Ophthalmology Case Reports, 2022
Purpose: This article reports the case of a 21-year-old woman with both hypertensive retinopathy and Purtscher-like retinopathy in association with C3 glomerulopathy.
Moosa Zaidi, Kapil Mishra, Huy Vu Nguyen, Paul Peter Miller, Hashem Ghoraba, Irmak Karaca, Wataru Matsumiya, Quan Dong Nguyen, Loh-Shan Bryan Leung   +8 more
doaj   +1 more source

Favorable effect of bortezomib in dense deposit disease associated with monoclonal gammopathy: a case report

BMC Nephrology, 2018
Background Complement component 3 (C3) glomerulopathy, which includes dense deposit disease (DDD) and C3 glomerulonephritis, is caused by dysregulation of the alternative complement pathway.
Shuma Hirashio, Ayaka Satoh, Takahiro Arima, Kouichi Mandai, Tadasuke Awaya, Kumi Oshima, Shigeo Hara, Takao Masaki   +7 more
doaj   +1 more source