C3 glomerulopathies: dense deposit disease and C3 glomerulonephritis [PDF]
Frontiers in Medicine, 2023 Dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are types of membranoproliferative glomerulonephritis classified as C3 glomerulopathies.
Claudio Ponticelli +4 more
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The impact of reclassification of C3 predominant glomerulopathies on diagnostic accuracy, outcome and prognosis in patients with C3 glomerulonephritis [PDF]
BMC Nephrology, 2020 Background C3 glomerulonephritis is a recently described entity with heterogeneous histopathological features. This study was conducted to assess the effect of reclassification of C3 glomerulopathies on renal outcomes, mortality, and response to therapy.
P. Puri +5 more
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C3-glomerulonephritis in New Zealand – a case series [PDF]
BMC Nephrology, 2020 Background C3-glomerulonephritis can lead to progressive renal impairment from complement-mediated glomerular injury. Incidence and outcomes of C3-glomerulonephritis are not known in the New Zealand population.
Luke J. Sutherland, Hari Talreja
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Pembrolizumab induced-C3 glomerulonephritis and RBC cast nephropathy: a case report. [PDF]
BMC Nephrol, 2023 Background Immune checkpoint inhibitors (ICIs) are increasingly being used in the treatment of several cancers. Pembrolizumab is an anti-programmed cell death-1 (anti-PD-1) monoclonal antibody that is approved for the treatment of metastatic non-small ...
Yang Z, Xu H, Gou S, Wu H, Hu Z.
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C3 Glomerulonephritis Associated with Monoclonal Gammopathy of Renal Significance
Acta Médica Portuguesa, 2021 Introduction: Monoclonal gammopathy of renal significance (MGRS) is described as a hematologic condition characterized by nephrotoxic monoclonal proteins produced by a non-malignant B-cell or plasma cell clone. Nevertheless, MGRS can cause serious renal
Inês Gomes-Alves, Inês Castro-Ferreira
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Case Report: Chronic Lymphocytic Leukemia With Recurrent Complement-Mediated Thrombotic Microangiopathy and C3 Glomerulonephritis. [PDF]
Front Med (Lausanne), 2022 Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a monoclonal B cell lymphocytosis that produces nephrotoxic monoclonal immunoglobulin (MIg).
Ma T, Wang H, Su T, Wang S.
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Co-existence of Alport syndrome and C3 glomerulonephritis in a proband with family history. [PDF]
Eur J Med Res, 2021 Background Alport syndrome and C3 glomerulonephritis (C3GN) are rare kidney diseases, frequently responsible for familial haematuria, proteinuria, and renal impairment.
Ding Y +6 more
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C3 glomerulonephritis associated with monoclonal gammopathy: a retrospective case series study from a single institute in China. [PDF]
Ren Fail, 2021 Objective To investigate the demographic and clinicopathological features and renal outcomes of Chinese patients with C3 glomerulonephritis in the setting of monoclonal gammopathy.
Zhang X +5 more
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Demographic, clinical characteristics and treatment outcomes of immune-complex membranoproliferative glomerulonephritis and C3 glomerulonephritis in Japan: A retrospective analysis of data from the Japan Renal Biopsy Registry. [PDF]
PLoS One, 2021 The reclassification of membranoproliferative glomerulonephritis (MPGN) into immune-complex MPGN (IC-MPGN) and C3 glomerulopathy (C3G) based on immunofluorescence findings in kidney biopsies has provided insights into these two distinct diseases.
Nakagawa N +19 more
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Pegcetacoplan for the Treatment of Paediatric C3 Glomerulonephritis: A Case Report. [PDF]
Nephrology (Carlton)Complement 3 glomerulonephritis (C3GN) is a rare glomerular disease involving dysregulation of the complement system. We describe our experience using pegcetacoplan, an inhibitor of C3 and its activation fragment, C3b, for treatment‐resistant C3GN in a 9‐
Guzman GL, Perry KW.
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