Results 31 to 40 of about 18,807 (198)
Timing of eculizumab therapy for C3 glomerulonephritis. [PDF]
Clin Kidney J, 2015 Eculizumab is an anti-C5 antibody that inhibits C5 cleavage and prevents the generation of the terminal complement complex C5b-9. Eculizumab is licensed to treat paroxysmal nocturnal haemoglobinuria or atypical haemolytic uraemic syndrome (aHUS). Clinical trials are ongoing for C3 glomerulopathy.
Rodriguez-Osorio L, Ortiz A.
europepmc +3 more sources
Clinico-Pathogenic Similarities and Differences between Infection-Related Glomerulonephritis and C3 Glomerulopathy [PDF]
, 2023 Recently, the comprehensive concept of “infection-related glomerulonephritis (IRGN)” has replaced that of postinfectious glomerulonephritis (PIGN) because of the diverse infection patterns, epidemiology, clinical features, and pathogenesis ...
Kazuhiro Takeuchi +8 more
core +1 more source
Effectiveness of mycophenolate mofetil in C3 glomerulonephritis [PDF]
Kidney International, 2015 C3 glomerulonephritis is a clinicopathologic entity defined by the presence of isolated or dominant deposits of C3 on immunofluorescence. To explore the effect of immunosuppression on C3 glomerulonephritis, we studied a series of 60 patients in whom a complete registry of treatments was available over a median follow-up of 47 months.
Cristina, Rabasco +30 more
openaire +3 more sources
Immune Complex-Mediated Crescentic Glomerulonephritis [PDF]
Journal of Clinical and Diagnostic Research, 2022 Immune complex-mediated Glomerulonephritis (GN) comprises a group of disorders including Immunoglobulin A (IgA) nephropathy, IgA vasculitis, lupus nephritis, infection-related GN {poststreptococcal, Hepatitis C Virus (HCV)}, and fibrillary GN with ...
Dhruvi Reddy +2 more
doaj +1 more source
Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance [PDF]
, 2010 Complement activation is known to have deleterious effects on organ transplantation. On the other hand, the complement system is also known to have an important role in regulating immune responses.
Cook, T +21 more
core +1 more source
Urinary Excretion of C3 Antigen in Glomerulonephritis [PDF]
BMJ, 1974 C3 and fibrin degradation products (F.D.P.) have been measured in early morning urine samples from 38 normal people and 123 patients with glomerulonephritis. Normal urine contained less than 0.3 mug of either antigen per ml. C3 and F.D.P. were both detected in the urine of many patients with glomerulonephritis. Levels above 1 mug/ml were exceptional in
B D, Williams +4 more
openaire +2 more sources
Immune complex glomerulonephritis in C4- and C3-deficient mice [PDF]
, 1998 Immune complex glomerulonephritis in C4- and C3-deficient mice. In this study, we examined the roles of C4 and C3 in immune complex glomerulonephritis by actively immunizing C4-deficient (C4 –/–), C3 deficient (C3 –/–) and wild-type mice with apoferritin.
Alexander, Jessy J. +11 more
core +1 more source
C3 Glomerulopathy: recent advances and an update on management [PDF]
Brazilian Journal of NephrologyC3 glomerulopathy (C3G) is a clinicopathologic entity characterized by glomerular inflammation with dominant staining for C3 on immunofluorescence microscopy.
Lilian Monteiro Pereira Palma +2 more
doaj +4 more sources
Frontiers in Pediatrics, 2022 Coronavirus disease 2019 (COVID-19) may cause a wide spectrum of kidney pathologies. The impact of COVID-19 is unclear in the context of the complement system abnormalities, including C3 glomerulopathy (C3G).
Nastaran Daneshgar +7 more
doaj +1 more source
Eculizumab as a New Treatment for Severe Acute Post-infectious Glomerulonephritis: Two Case Reports
Frontiers in Medicine, 2021 Acute post-infections glomerulonephritis (APIGN) is a frequent cause of glomerulonephritis and represents the most common cause of acute glomerulonephritis in children.
Hassib Chehade +12 more
doaj +1 more source