Results 31 to 40 of about 24,964 (213)
C3 Glomerulopathy: A Rare Entity with Future Directions
Revista Portuguesa de Nefrologia e Hipertensão, 2023 C3 glomerulopathies are a rare group of glomerular diseases resulting from excessive activation of the alternative complement pathway. The pathogenesis involves genetic, acquired, or immunologic defects in regulators of the alternative complement ...
Sara Vilela +5 more
doaj +1 more source
COMPLEMENT-MEDIATED ADIPOCYTE LYSIS BY NEPHRITIC FACTOR SERA [PDF]
, 1993 Recent data indicate a previously unsuspected link between the complement system and adipocyte biology. Murine adipocytes produce key components of the alternative pathway of complement and are able to activate this pathway.
Lachmann, PJ +4 more
core +1 more source
IgA Vasculitis and C3 Glomerulonephritis: One Patient... Various Autoimmune Diseases
Gazeta Médica, 2022 Leucocytoclastic vasculitis refers to a small vessel vasculitis caused by immune complexes, infections and medications. IgA or IgM/IgG immune complexes can be found in direct immunofluorescence studies suggesting specific forms of leucocytoclastic ...
Ana Margarida Pedro Antunes Ferreira Gaudêncio +2 more
doaj +4 more sources
C3 glomerulonephritis: two pediatric cases
Paediatria Croatica, 2013 C3 glomerulopathy defi nes a group of diseases characterized with deposition of C3 alone in the glomeruli in the absence of deposition of immunoglobulin or other complement products. These diseases include dense deposit disease, type 1 membranoproliferative glomerulonephritis (MPGN), familial type 3 MPGN, familial C3 glomerulonephritis associated with ...
Alaygut, Demet +5 more
openaire +2 more sources
Frontiers in Immunology, 2021 BackgroundFactor H-related protein 5 (FHR-5) is a member of the complement Factor H protein family. Due to the homology to Factor H, the main complement regulator of the alternative pathway, it may also be implicated in the pathomechanism of kidney ...
Nóra Garam +74 more
doaj +1 more source
Refractory C3 glomerulonephritis unresponsive to bortezomib
NefrologíaTaha Enes Cetin +4 more
doaj +2 more sources
Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice [PDF]
, 2019 Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-function mutations in complement-regulating proteins or gain-of-function mutations in complement-activating proteins.
Atkinson, John P +11 more
core +3 more sources
Effectiveness of mycophenolate mofetil in C3 glomerulonephritis [PDF]
Kidney International, 2015 C3 glomerulonephritis is a clinicopathologic entity defined by the presence of isolated or dominant deposits of C3 on immunofluorescence. To explore the effect of immunosuppression on C3 glomerulonephritis, we studied a series of 60 patients in whom a complete registry of treatments was available over a median follow-up of 47 months.
Cristina, Rabasco +30 more
openaire +2 more sources
Regulating complement in the kidney: insights from CFHR5 nephropathy
Disease Models & Mechanisms, 2011 Complement factor H related protein 5 (CFHR5) nephropathy is a monogenic disorder of complement regulation that is endemic in Cyprus. The disease is characterised by haematuria, C3 glomerulonephritis and kidney failure. Its identification suggests a role
Daniel P. Gale, Matthew C. Pickering
doaj +1 more source
Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis [PDF]
Kidney Research and Clinical Practice, 2023 Background Alternative complement pathway dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and ...
Jiwon Ryu +14 more
doaj +1 more source