Results 1 to 10 of about 16,816 (256)
A long history of dense deposit disease [PDF]
BMC Ophthalmology, 2018 Background Dense Deposit Disease is a rare condition affecting the Bruch’s membrane and the glomerular basement membrane. We report the progression of the ocular manifestations over a 30 year follow up period, longer than any previous report.
Alan Cunningham, Ajay Kotagiri
doaj +6 more sources
C3 glomerulopathies: dense deposit disease and C3 glomerulonephritis [PDF]
Frontiers in Medicine, 2023 Dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are types of membranoproliferative glomerulonephritis classified as C3 glomerulopathies.
Claudio Ponticelli +4 more
doaj +6 more sources
Mol Immunol, 2011 Dense deposit disease (DDD) is an orphan disease that primarily affects children and young adults without sexual predilection. Studies of its pathophysiology have shown conclusively that it is caused by fluid-phase dysregulation of the alternative pathway of complement, however the role played by genetics and autoantibodies like C3 nephritic factors ...
Smith RJ, Harris CL, Pickering MC.
europepmc +6 more sources
Blockade of Alternative Complement Pathway in Dense Deposit Disease [PDF]
Case Reports in Nephrology, 2014 A patient aged 17 with dense deposit disease associated with complement activation, circulating C3 Nef, and Factor H mutation presented with nephrotic syndrome and hypertension.
Aurore Berthe-Aucejo +6 more
doaj +7 more sources
Dense deposit disease and C3 glomerulopathy.
Semin Nephrol, 2013 C3 glomerulopathy refers to those renal lesions characterized histologically by predominant C3 accumulation within the glomerulus, and pathogenetically by aberrant regulation of the alternative pathway of complement. Dense deposit disease is distinguished from other forms of C3 glomerulopathy by its characteristic appearance on electron microscopy. The
Barbour TD +2 more
europepmc +5 more sources
The Retinal Complications of C3 Dense Deposit Disease: A Scoping Review [PDF]
VisionPeople with C3 Dense Deposit Disease (C3DDD), a rare autoimmune disease, often also have ocular complications. Due to the rarity of this disease, there is little known about ocular complications in populations across the world. This paper aimed to assess
Jolene McCarney +4 more
doaj +3 more sources
A Child with Dense Deposit Disease and Decreased Classic Complement Pathway Activity [PDF]
Acta Clinica Croatica, 2021 We report a rare case of nephritic syndrome underlying dense deposit disease (DDD) with alternative complement pathway dysfunction explained with both C3 nephritic factor (C3NeF) antibodies and DDD associated polymorphism of factor H. An 8-year-old boy
Ivana Trutin +4 more
doaj +2 more sources
Dense Deposit Disease Involving C3 and C4d Deposits. [PDF]
Indian J Nephrol, 2018 Dense deposit disease (DDD), earlier called Type II membranoproliferative glomerulonephritis is distinct disease having frequent relapses reaching end-stage kidney disease by 10-year in up to 50%-60% of cases and high recurrence rate in the allograft. The term DDD is derived from its distinctive ribbon-like osmiophilic deposits in the lamina densa of ...
Vankalakunti M +6 more
europepmc +3 more sources
Iptacopan treatment for recurrent dense deposit disease after kidney transplant: A case report [PDF]
SAGE Open Medical Case ReportsC3 glomerulopathies, including dense deposit disease, are rare kidney disorders caused by dysregulation of the alternative complement pathway. Recurrence after kidney transplantation is common and can threaten graft survival.
Lean AlKhatib +3 more
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Meningococcemia in a Boy with Dense Deposit Disease Receiving the C5 Complement Inhibitor Ravulizumab: A Case Report [PDF]
Clinical Practice and Cases in Emergency MedicineIntroduction: Dense deposit disease, also known as C3 glomerulopathy, is a rare renal disorder caused by abnormal complement deposition in the glomerular basement membrane.
Andrew J. Gonedes +4 more
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