Results 41 to 50 of about 62,552 (281)
Anti-factor H antibody affecting factor H cofactor activity in a patient with dense deposit disease. [PDF]
Clin Kidney J, 2012 Nozal P +7 more
europepmc +2 more sources
Complement-Mediated Glomerular Diseases: A Tale of 3 Pathways
Kidney International Reports, 2016 A renewed interest in the role of complement in the pathogenesis of glomerular diseases has improved our understanding of their basic, underlying physiology.
Andrew S. Bomback +2 more
doaj +1 more source
Kayser fleischer ring: A strong clinical indicator of neuro-wilson's
TNOA Journal of Ophthalmic Science and Research, 2017 A female child presenting with features of lupus nephritis was referred for ophthalmic evaluation related to autoimmune diseases. It turned out to be a dense yellow-brown deposit of Kayser Fleischer (KF) Ring and sunflower cataract following which ...
Rajalakshmi Selvaraj +2 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Clinical Practice and Cases in Emergency MedicineIntroduction: Dense deposit disease, also known as C3 glomerulopathy, is a rare renal disorder caused by abnormal complement deposition in the glomerular basement membrane.
Andrew J. Gonedes +4 more
doaj +1 more source
C3 Glomerulopathy: A Review with Emphasis on Ultrastructural Features
Glomerular Diseases, 2022 C3 glomerulopathy (C3G) is a rare disease resulting from dysregulation of the alternative complement pathway, resulting in the deposition of complement component 3 (C3) in the kidney.
Jean Hou, Kevin Yi Mi Ren, Mark Haas
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
What makes gouty inflammation so variable? [PDF]
, 2017 Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem.
Terkeltaub, Robert
core +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Treatment of C3 Glomerulopathy in Adult Kidney Transplant Recipients: A Systematic Review
Medical Sciences, 2020 Background: C3 glomerulopathy (C3G), a rare glomerular disease mediated by alternative complement pathway dysregulation, is associated with a high rate of recurrence and graft loss after kidney transplantation (KTx).
Maria L Gonzalez Suarez +11 more
doaj +1 more source