Results 41 to 50 of about 16,816 (256)
Complement-Mediated Glomerular Diseases: A Tale of 3 Pathways
Kidney International Reports, 2016 A renewed interest in the role of complement in the pathogenesis of glomerular diseases has improved our understanding of their basic, underlying physiology.
Andrew S. Bomback +2 more
doaj +1 more source
Recurrent C3 Glomerulonephritis with an ADAMTS 13 Gene Variant: A Case Report and Literature Review
Saudi Journal of Kidney Diseases and Transplantation, 2021 C3 glomerulonephritis (C3GN) is a recently described form of GN that mainly occurs in children and young adults. It results from dysregulation of the alternative complement pathway. Studies have shown that dense deposit disease has a high recurrence rate;
Reem A. Al Zahrani +2 more
doaj +1 more source
Kayser fleischer ring: A strong clinical indicator of neuro-wilson's
TNOA Journal of Ophthalmic Science and Research, 2017 A female child presenting with features of lupus nephritis was referred for ophthalmic evaluation related to autoimmune diseases. It turned out to be a dense yellow-brown deposit of Kayser Fleischer (KF) Ring and sunflower cataract following which ...
Rajalakshmi Selvaraj +2 more
doaj +1 more source
C3 Glomerulopathy: A Review with Emphasis on Ultrastructural Features
Glomerular Diseases, 2022 C3 glomerulopathy (C3G) is a rare disease resulting from dysregulation of the alternative complement pathway, resulting in the deposition of complement component 3 (C3) in the kidney.
Jean Hou, Kevin Yi Mi Ren, Mark Haas
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Eculizumab in dense-deposit disease after renal transplantation
, 2014 Dense-deposit disease (DDD) is a rare glomerulopathy characterized by electron-dense deposits in the glomerular basement membrane. About 50 % of patients with DDD progress to end-stage kidney disease and require dialysis within 10 years of diagnosis, and
Rodríguez de Córdoba, Santiago +7 more
core +1 more source
The role of complement iC3b in dense deposit disease [PDF]
, 2015 Dense deposit disease (DDD) is a rare, progressive and incurable kidney disease characterized by complement C3 accumulation along the glomerular basement membrane (GBM).
Barbour, Thomas David
core +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Treatment of C3 Glomerulopathy in Adult Kidney Transplant Recipients: A Systematic Review
Medical Sciences, 2020 Background: C3 glomerulopathy (C3G), a rare glomerular disease mediated by alternative complement pathway dysregulation, is associated with a high rate of recurrence and graft loss after kidney transplantation (KTx).
Maria L Gonzalez Suarez +11 more
doaj +1 more source
Diagnostic Problems in C3 Glomerulopathy
Biomedicines, 2023 Background: C3 glomerulopathies (C3GN) are a group of rare kidney diseases associated with impaired complement regulation. The effects of this disease include the accumulation of complement C3 in the kidneys. Based on the clinical data, as well as light,
Leszek Niepolski +11 more
doaj +1 more source