Results 61 to 70 of about 16,816 (256)

C3 glomerulopathy in children: experience at a resource-limited center [PDF]

Clinical and Experimental Pediatrics
Background In children, C3 glomerulopathy (C3G) is a heterogeneous disease characterized by diverse clinicopathological profiles and kidney outcomes. However, diagnostic work-up in resource-limited settings is challenging because of the unavailability of
Soumya Reddy, Abhishek Ghante, Mahesha Vankalakunti, Anil Vasudevan   +3 more
doaj   +1 more source

Lysolipids are prominent in subretinal drusenoid deposits, a high-risk phenotype in age-related macular degeneration

Frontiers in Ophthalmology, 2023
IntroductionAge related macular degeneration (AMD) causes legal blindness worldwide, with few therapeutic targets in early disease and no treatments for 80% of cases.
David M. G. Anderson, Ankita Kotnala, Ankita Kotnala, Lukasz G. Migas, N. Heath Patterson, Léonore E. M. Tideman, Dongfeng Cao, Bibek Adhikari, Jeffrey D. Messinger, Thomas Ach, Sara Tortorella, Raf Van de Plas, Raf Van de Plas, Christine A. Curcio, Kevin L. Schey   +14 more
doaj   +1 more source

Dense Deposit Disease: A 29-Years Electron Microscopy Experience

, 2013
Introduction: Dense Deposit Disease (DDD) is a devastating renal disease that leads to renal failure within 10 years of diagnosis in about half of affected patients.
Salman, MI, Elhefnawy, NG, Seif, EI, Ibrahim, EA   +3 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Extraglomerular dense deposits in dense deposit disease.

Archives of pathology & laboratory medicine, 1982
A search was made for dense deposits in sites other than kidney with the use of skin biopsy specimens obtained from patients with dense-deposit disease (DDD) and tissues from autopsy material. Dense deposits were not present in basement membranes at the epidermal-dermal junction or around dermal capillaries in three skin biopsy specimens.
P, Thorner, R, Baumal
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

C3 Glomerulopathy Diagnosis, Current Treatments, and Emerging Therapies

Kidney Medicine
C3 glomerulopathy (C3G) is characterized by prominent deposition of complement component C3 in the kidney glomeruli, leading to glomerular inflammation.
Mahtab Mashayekhi, Jonathan E. Zuckerman, Jonathan Barratt, Richard J. Glassock, Fernando Caravaca-Fontán, Raymond K. Hsu, Arun Rajasekaran, Edgar Lerma, Sahibzadi Mahrukh Noor, Amir Abdipour, Sayna Norouzi   +10 more
doaj   +1 more source

Diagnostic and Prognostic Comparison of Immune-Complex-Mediated Membranoproliferative Glomerulonephritis and C3 Glomerulopathy

Cells, 2023
Membranoproliferative glomerulonephritis (MPGN) is subdivided into immune-complex-mediated glomerulonephritis (IC-MPGN) and C3 glomerulopathy (C3G).
Marja Kovala, Minna Seppälä, Anne Räisänen-Sokolowski, Seppo Meri, Eero Honkanen, Kati Kaartinen   +5 more
doaj   +1 more source

Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies

, 2012
Dense deposit disease and glomerulonephritis with isolated C3 deposits are glomerulopathies characterized by deposits of C3 within or along the glomerular basement membrane.
Le Quintrec, Moglie, Karras, Alexandre, Roumenina, Lubka T., Frémeaux-Bacchi, Véronique, Dragon-Durey, Marie-Agnès, Provot, François, Servais, Aude, Noël, Laure-Hélène, Niaudet, Patrick, Macher, Marie-Alice, Grünfeld, Jean-Pierre, Ngo, Stephanie, Zuber, Julien, Moulin, Bruno, Lesavre, Philippe   +14 more
core   +1 more source