Results 61 to 70 of about 62,552 (281)
Human factor H-related protein 2 (CFHR2) regulates complement activation. [PDF]
PLoS ONE, 2013 Mutations and deletions within the human CFHR gene cluster on chromosome 1 are associated with diseases, such as dense deposit disease, CFHR nephropathy or age-related macular degeneration. Resulting mutant CFHR proteins can affect complement regulation.
Hannes U Eberhardt +10 more
doaj +1 more source
Monoclonal gammopathy of renal significance: Diagnostic workup [PDF]
, 2017 The clinical spectrum of diseases associated with monoclonal gammopathies is wide and they are most commonly the consequence of renal deposition of monoclonal immunoglobulin or its components.
Cabrita, A. +5 more
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Dense deposit disease in a child with febrile sore throat
Saudi Journal of Kidney Diseases and Transplantation, 2017 Dense deposit disease or membranoproliferative glomerulonephritis type II is a rare glomerulopathy characterized on renal biopsy by deposition of abnormal electron-dense material in the glomerular basement membrane.
Giovanni Conti +4 more
doaj
Function and Dysfunction of Complement Factor H During Formation of Lipid-Rich Deposits
Frontiers in Immunology, 2020 Complement-mediated inflammation or dysregulation in lipid metabolism are associated with the pathogenesis of several diseases. These include age-related macular degeneration (AMD), C3 glomerulonephritis (C3GN), dense deposit disease (DDD ...
Seppo Meri, Seppo Meri, Karita Haapasalo
doaj +1 more source
Frontiers in Ophthalmology, 2023 IntroductionAge related macular degeneration (AMD) causes legal blindness worldwide, with few therapeutic targets in early disease and no treatments for 80% of cases.
David M. G. Anderson +14 more
doaj +1 more source
Iron biochemistry is correlated with amyloid plaque morphology in an established mouse model of Alzheimer’s disease [PDF]
, 2017 A signature characteristic of Alzheimer's disease (AD) is aggregation of amyloid-beta (Aβ) fibrils in the brain. Nevertheless, the links between Aβ and AD pathology remain incompletely understood.
Collingwood, Joanna F. +7 more
core +3 more sources
Dense intramembranous deposit disease: New pathologic features
Kidney International, 1984 The pathologic and clinical features of 16 patients with dense intramembranous deposit disease are described. By light microscopy nine patients had membranoproliferative glomerulonephritis, five had focal segmental necrotizing glomerulonephritis with segmental epithelial crescents, four of whom also had a prominent tubulointerstitial nephritis, and two
Sibley, Richard K., Kim, Youngki
openaire +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source