Results 51 to 60 of about 62,552 (281)

Diagnostic Problems in C3 Glomerulopathy

Biomedicines, 2023
Background: C3 glomerulopathies (C3GN) are a group of rare kidney diseases associated with impaired complement regulation. The effects of this disease include the accumulation of complement C3 in the kidneys. Based on the clinical data, as well as light,
Leszek Niepolski, Anna Czekała, Monika Seget-Dubaniewicz, Magdalena Frydrychowicz, Patrycja Talarska-Markiewicz, Angelika Kowalska, Jagoda Szmelter, Wiesława Salwa-Żurawska, Tomasz Sirek, Dawid Sobański, Beniamin Oskar Grabarek, Jakub Żurawski   +11 more
doaj   +1 more source

The Response of Cerebral Cortex to Haemorrhagic Damage: Experimental Evidence from a Penetrating Injury Model [PDF]

, 2015
Understanding the response of the brain to haemorrhagic damage is important in haemorrhagic stroke and increasingly in the understanding the cerebral degeneration and dementia that follow head trauma and head-impact sports.
Johnstone, Daniel M., Marotte, Lauren, Purushothuman, Sivaraman, Stone, Jonathan, Stowe, Sally   +4 more
core   +1 more source

Membranoproliferative Glomerulonephritis Type II (Dense Deposit Disease) [PDF]

Journal of the American Society of Nephrology, 2005
Membranoproliferative glomerulonephritis type II (MPGN II) is a rare disease characterized by the deposition of abnormal electron-dense material within the glomerular basement membrane of the kidney and often within Bruch's membrane in the eye. The diagnosis is made in most patients between the ages of 5 and 15 yr, and within 10 yr, approximately half ...
Gerald B, Appel, H Terence, Cook, Gregory, Hageman, J Charles, Jennette, Michael, Kashgarian, Michael, Kirschfink, John D, Lambris, Lynne, Lanning, Hans U, Lutz, Seppo, Meri, Noel R, Rose, David J, Salant, Sanjeev, Sethi, Richard J H, Smith, William, Smoyer, Hope F, Tully, Sean P, Tully, Patrick, Walker, Michael, Welsh, Reinhard, Würzner, Peter F, Zipfel   +20 more
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

FHR-5 Serum Levels and CFHR5 Genetic Variations in Patients With Immune Complex-Mediated Membranoproliferative Glomerulonephritis and C3-Glomerulopathy

Frontiers in Immunology, 2021
BackgroundFactor H-related protein 5 (FHR-5) is a member of the complement Factor H protein family. Due to the homology to Factor H, the main complement regulator of the alternative pathway, it may also be implicated in the pathomechanism of kidney ...
Nóra Garam, Marcell Cserhalmi, Zoltán Prohászka, Zoltán Prohászka, Ágnes Szilágyi, Nóra Veszeli, Nóra Veszeli, Edina Szabó, Barbara Uzonyi, Attila Iliás, Christof Aigner, Alice Schmidt, Martina Gaggl, Gere Sunder-Plassmann, Dóra Bajcsi, Jürgen Brunner, Alexandra Dumfarth, Daniel Cejka, Stefan Flaschberger, Hana Flögelova, Ágnes Haris, Ágnes Hartmann, Andreas Heilos, Thomas Mueller, Krisztina Rusai, Klaus Arbeiter, Johannes Hofer, Johannes Hofer, Johannes Hofer, Dániel Jakab, Mária Sinkó, Erika Szigeti, Csaba Bereczki, Viktor Janko, Kata Kelen, György S. Reusz, Attila J. Szabó, Nóra Klenk, Krisztina Kóbor, Nika Kojc, Maarten Knechtelsdorfer, Mario Laganovic, Adrian Catalin Lungu, Anamarija Meglic, Rina Rus, Tanja Kersnik Levart, Ernesta Macioniene, Marius Miglinas, Anna Pawłowska, Tomasz Stompór, Ludmila Podracka, Michael Rudnicki, Gert Mayer, Romana Rysava, Jana Reiterova, Marijan Saraga, Marijan Saraga, Tomáš Seeman, Jakub Zieg, Eva Sládková, Natasa Stajic, Tamás Szabó, Andrei Capitanescu, Simona Stancu, Miroslav Tisljar, Kresimir Galesic, András Tislér, Inga Vainumäe, Martin Windpessl, Tomas Zaoral, Galia Zlatanova, Mihály Józsi, Mihály Józsi, Dorottya Csuka, Dorottya Csuka   +74 more
doaj   +1 more source

Interpretable classification of Alzheimer's disease pathologies with a convolutional neural network pipeline. [PDF]

, 2018
Neuropathologists assess vast brain areas to identify diverse and subtly-differentiated morphologies. Standard semi-quantitative scoring approaches, however, are coarse-grained and lack precise neuroanatomic localization.
Beckett, Laurel, Chuang, Kangway V, DeCarli, Charles, Dugger, Brittany N, Jin, Lee-Way, Keiser, Michael J, Tang, Ziqi   +6 more
core  

Dynamics of evaporative colloidal patterning

, 2014
Drying suspensions often leave behind complex patterns of particulates, as might be seen in the coffee stains on a table. Here we consider the dynamics of periodic band or uniform solid film formation on a vertical plate suspended partially in a drying ...
Aizenberg, Joanna, Kaplan, C. Nadir, Mahadevan, L., Mandre, Shreyas, Wu, Ning   +4 more
core   +1 more source

Effect of Habitat on Blow Fly (Diptera: Calliphoridae) Oviposition in Michigan [PDF]

, 2017
Forensic entomology applies data gained from insects to aid the criminal justice system. Blow flies (Diptera: Calliphoridae) are usually the first insects to arrive and oviposit (lay eggs) on carrion.
Bugajski, Kristi, Stoller, Parker
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Eculizumab in C3 Glomerulopathy: A Systematic Review of Therapeutic Efficacy and Clinical Outcomes

Pharmaceutics
Background: C3 glomerulopathies (C3G), including dense deposit disease (DDD) and C3 glomerulonephritis (C3GN), are rare kidney disorders driven by dysregulation of the alternative complement pathway.
Dominik Lewandowski, Mateusz Konieczny, Krzysztof Chrzanowski, Marta Jakubowska, Zuzanna Paryzek, Miłosz Miedziaszczyk, Ilona Idasiak-Piechocka   +6 more
doaj   +1 more source