Results 31 to 40 of about 5,589,445 (235)

Recurrent C3 Glomerulonephritis with an ADAMTS 13 Gene Variant: A Case Report and Literature Review

Saudi Journal of Kidney Diseases and Transplantation, 2021
C3 glomerulonephritis (C3GN) is a recently described form of GN that mainly occurs in children and young adults. It results from dysregulation of the alternative complement pathway. Studies have shown that dense deposit disease has a high recurrence rate;
Reem A. Al Zahrani, Ahmed M. A. Y. Nazmi, Turki O. Al Hussain   +2 more
doaj   +1 more source

Kayser fleischer ring: A strong clinical indicator of neuro-wilson's

TNOA Journal of Ophthalmic Science and Research, 2017
A female child presenting with features of lupus nephritis was referred for ophthalmic evaluation related to autoimmune diseases. It turned out to be a dense yellow-brown deposit of Kayser Fleischer (KF) Ring and sunflower cataract following which ...
Rajalakshmi Selvaraj, Subashini Kaliaperumal, Pooja Kumari   +2 more
doaj   +1 more source

C3 Glomerulopathy: A Review with Emphasis on Ultrastructural Features

Glomerular Diseases, 2022
C3 glomerulopathy (C3G) is a rare disease resulting from dysregulation of the alternative complement pathway, resulting in the deposition of complement component 3 (C3) in the kidney.
Jean Hou, Kevin Yi Mi Ren, Mark Haas
doaj   +1 more source

Dense deposit disease in Korean children: a multicenter clinicopathologic study. [PDF]

J Korean Med Sci, 2012
The purpose of this study was to investigate the clinical, laboratory, and pathologic characteristics of dense deposit disease (DDD) in Korean children and to determine whether these characteristics differ between Korean and American children with DDD ...
Park SJ, Kim YJ, Ha TS, Lim BJ, Jeong HJ, Park YH, Lee DY, Kim PK, Kim KS, Chung WY, Shin JI.   +10 more
europepmc   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Treatment of C3 Glomerulopathy in Adult Kidney Transplant Recipients: A Systematic Review

Medical Sciences, 2020
Background: C3 glomerulopathy (C3G), a rare glomerular disease mediated by alternative complement pathway dysregulation, is associated with a high rate of recurrence and graft loss after kidney transplantation (KTx).
Maria L Gonzalez Suarez, Charat Thongprayoon, Panupong Hansrivijit, Karthik Kovvuru, Swetha R Kanduri, Narothama R Aeddula, Aleksandra I Pivovarova, Api Chewcharat, Tarun Bathini, Michael A Mao, Arpita Basu, Wisit Cheungpasitporn   +11 more
doaj   +1 more source

FHR-5 Serum Levels and CFHR5 Genetic Variations in Patients With Immune Complex-Mediated Membranoproliferative Glomerulonephritis and C3-Glomerulopathy

Frontiers in Immunology, 2021
BackgroundFactor H-related protein 5 (FHR-5) is a member of the complement Factor H protein family. Due to the homology to Factor H, the main complement regulator of the alternative pathway, it may also be implicated in the pathomechanism of kidney ...
Nóra Garam, Marcell Cserhalmi, Zoltán Prohászka, Zoltán Prohászka, Ágnes Szilágyi, Nóra Veszeli, Nóra Veszeli, Edina Szabó, Barbara Uzonyi, Attila Iliás, Christof Aigner, Alice Schmidt, Martina Gaggl, Gere Sunder-Plassmann, Dóra Bajcsi, Jürgen Brunner, Alexandra Dumfarth, Daniel Cejka, Stefan Flaschberger, Hana Flögelova, Ágnes Haris, Ágnes Hartmann, Andreas Heilos, Thomas Mueller, Krisztina Rusai, Klaus Arbeiter, Johannes Hofer, Johannes Hofer, Johannes Hofer, Dániel Jakab, Mária Sinkó, Erika Szigeti, Csaba Bereczki, Viktor Janko, Kata Kelen, György S. Reusz, Attila J. Szabó, Nóra Klenk, Krisztina Kóbor, Nika Kojc, Maarten Knechtelsdorfer, Mario Laganovic, Adrian Catalin Lungu, Anamarija Meglic, Rina Rus, Tanja Kersnik Levart, Ernesta Macioniene, Marius Miglinas, Anna Pawłowska, Tomasz Stompór, Ludmila Podracka, Michael Rudnicki, Gert Mayer, Romana Rysava, Jana Reiterova, Marijan Saraga, Marijan Saraga, Tomáš Seeman, Jakub Zieg, Eva Sládková, Natasa Stajic, Tamás Szabó, Andrei Capitanescu, Simona Stancu, Miroslav Tisljar, Kresimir Galesic, András Tislér, Inga Vainumäe, Martin Windpessl, Tomas Zaoral, Galia Zlatanova, Mihály Józsi, Mihály Józsi, Dorottya Csuka, Dorottya Csuka   +74 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Diagnostic Problems in C3 Glomerulopathy

Biomedicines, 2023
Background: C3 glomerulopathies (C3GN) are a group of rare kidney diseases associated with impaired complement regulation. The effects of this disease include the accumulation of complement C3 in the kidneys. Based on the clinical data, as well as light,
Leszek Niepolski, Anna Czekała, Monika Seget-Dubaniewicz, Magdalena Frydrychowicz, Patrycja Talarska-Markiewicz, Angelika Kowalska, Jagoda Szmelter, Wiesława Salwa-Żurawska, Tomasz Sirek, Dawid Sobański, Beniamin Oskar Grabarek, Jakub Żurawski   +11 more
doaj   +1 more source