Results 31 to 40 of about 62,552 (281)
The next steps in improving the outcomes of advanced ovarian cancer [PDF]
, 2015 Worldwide ovarian cancer affects over 200,000 women per year. Overall survival rates are poor due to two predominate reasons. First, the majority of patients present with advanced disease creating significant difficulty with effecting disease eradication.
Blagden, S +3 more
core +1 more source
Treating C3 glomerulopathy with eculizumab
BMC Nephrology, 2018 Background C3 glomerulopathy (C3G) is a rare, but severe glomerular disease with grim prognosis. The complex pathogenesis is just unfolding, and involves acquired as well as inherited dysregulation of the alternative pathway of the complement cascade ...
Thomas Welte +7 more
doaj +1 more source
Diverse Clinical Presentations of C3 Dominant Glomerulonephritis
Frontiers in Medicine, 2020 C3 dominant immunofluorescence staining is present in a subset of patients with idiopathic immune complex membranoproliferative glomerulonephritis (iMPGN).
Ramy M. Hanna +13 more
doaj +1 more source
Dense deposit disease: clinicopathologic study of 32 pediatric and adult patients. [PDF]
Clin J Am Soc Nephrol, 2009 Dense deposit disease (DDD) is a rare disorder that most commonly affects children. This study reports the largest North American series addressing clinicopathologic and outcome differences in children and adults.Thirty-two patients with DDD were analyzed from the archives of Columbia University between 1977 and 2007.
Nasr SH +7 more
europepmc +4 more sources
Age and diabetes related changes of the retinal capillaries: an ultrastructural and immunohistochemical study [PDF]
, 2015 Normal human aging and diabetes are associated with a gradual decrease of cerebral flow in the brain with changes in vascular architecture. Thickening of the capillary basement membrane and microvascular fibrosis are evident in the central nervous system
ARTICO, Marco +10 more
core +1 more source
Diagnostic and therapeutic challenges in dense deposit disease: case report
PočkiWe report a complex case of a 15-year-old girl initially diagnosed with post-streptococcal glomerulonephritis (PSGN) but later identified as having dense deposit disease, which was initially classified as type 2 membranoproliferative glomerulonephritis ...
Anand Prasad +3 more
doaj +1 more source
Autoimmunity, 2018 Complement convertases are enzymatic complexes, which play a critical role in propagation and amplification of the complement cascade. Under physiological conditions, convertases decay shortly after being formed in either spontaneous or inhibitor-driven ...
Aleksandra Urban +6 more
doaj +1 more source
Regulating complement in the kidney: insights from CFHR5 nephropathy
Disease Models & Mechanisms, 2011 Complement factor H related protein 5 (CFHR5) nephropathy is a monogenic disorder of complement regulation that is endemic in Cyprus. The disease is characterised by haematuria, C3 glomerulonephritis and kidney failure. Its identification suggests a role
Daniel P. Gale, Matthew C. Pickering
doaj +1 more source
Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery. [PDF]
, 2018 Injectable hydrogels with tunable physiochemical and biological properties are potential tools for improving neural stem/progenitor cell (NSPC) transplantation to treat central nervous system (CNS) injury and disease.
Czechanski, A +6 more
core +1 more source
Recurrent C3 Glomerulonephritis with an ADAMTS 13 Gene Variant: A Case Report and Literature Review
Saudi Journal of Kidney Diseases and Transplantation, 2021 C3 glomerulonephritis (C3GN) is a recently described form of GN that mainly occurs in children and young adults. It results from dysregulation of the alternative complement pathway. Studies have shown that dense deposit disease has a high recurrence rate;
Reem A. Al Zahrani +2 more
doaj +1 more source