Results 31 to 40 of about 16,635 (234)
Regulating complement in the kidney: insights from CFHR5 nephropathy
Disease Models & Mechanisms, 2011 Complement factor H related protein 5 (CFHR5) nephropathy is a monogenic disorder of complement regulation that is endemic in Cyprus. The disease is characterised by haematuria, C3 glomerulonephritis and kidney failure. Its identification suggests a role
Daniel P. Gale, Matthew C. Pickering
doaj +1 more source
Complement-Mediated Glomerular Diseases: A Tale of 3 Pathways
Kidney International Reports, 2016 A renewed interest in the role of complement in the pathogenesis of glomerular diseases has improved our understanding of their basic, underlying physiology.
Andrew S. Bomback +2 more
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Recurrent C3 Glomerulonephritis with an ADAMTS 13 Gene Variant: A Case Report and Literature Review
Saudi Journal of Kidney Diseases and Transplantation, 2021 C3 glomerulonephritis (C3GN) is a recently described form of GN that mainly occurs in children and young adults. It results from dysregulation of the alternative complement pathway. Studies have shown that dense deposit disease has a high recurrence rate;
Reem A. Al Zahrani +2 more
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Autoimmunity, 2018 Complement convertases are enzymatic complexes, which play a critical role in propagation and amplification of the complement cascade. Under physiological conditions, convertases decay shortly after being formed in either spontaneous or inhibitor-driven ...
Aleksandra Urban +6 more
doaj +1 more source
Kayser fleischer ring: A strong clinical indicator of neuro-wilson's
TNOA Journal of Ophthalmic Science and Research, 2017 A female child presenting with features of lupus nephritis was referred for ophthalmic evaluation related to autoimmune diseases. It turned out to be a dense yellow-brown deposit of Kayser Fleischer (KF) Ring and sunflower cataract following which ...
Rajalakshmi Selvaraj +2 more
doaj +1 more source
C3 Glomerulopathy: A Review with Emphasis on Ultrastructural Features
Glomerular Diseases, 2022 C3 glomerulopathy (C3G) is a rare disease resulting from dysregulation of the alternative complement pathway, resulting in the deposition of complement component 3 (C3) in the kidney.
Jean Hou, Kevin Yi Mi Ren, Mark Haas
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Treatment of C3 Glomerulopathy in Adult Kidney Transplant Recipients: A Systematic Review
Medical Sciences, 2020 Background: C3 glomerulopathy (C3G), a rare glomerular disease mediated by alternative complement pathway dysregulation, is associated with a high rate of recurrence and graft loss after kidney transplantation (KTx).
Maria L Gonzalez Suarez +11 more
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Diagnostic Problems in C3 Glomerulopathy
Biomedicines, 2023 Background: C3 glomerulopathies (C3GN) are a group of rare kidney diseases associated with impaired complement regulation. The effects of this disease include the accumulation of complement C3 in the kidneys. Based on the clinical data, as well as light,
Leszek Niepolski +11 more
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