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Dense deposit disease (DDD) is an orphan disease that primarily affects children and young adults without sexual predilection. Studies of its pathophysiology have shown conclusively that it is caused by fluid-phase dysregulation of the alternative ...
Smith RJ, Harris CL, Pickering MC.
europepmc +3 more sources
Dense deposit disease and C3 glomerulopathy. [PDF]
SummaryC3 glomerulopathy refers to those renal lesions characterized histologically by predominant C3 accumulation within the glomerulus, and pathogenetically by aberrant regulation of the alternative pathway of complement.
Barbour TD +2 more
europepmc +3 more sources
Dense deposit disease in a child with febrile sore throat
Dense deposit disease or membranoproliferative glomerulonephritis type II is a rare glomerulopathy characterized on renal biopsy by deposition of abnormal electron-dense material in the glomerular basement membrane.
Giovanni Conti +4 more
doaj +3 more sources
Deposit insurance systems and bank risk [PDF]
The link from deposit insurance to bank risk taking has been widely analysed, but has been the subject of relatively little empirical work. This work contributes to the existing literature by exploring microeconomic aspects of the deposit insurance–bank
Davis, EP, Obasi, U
core +6 more sources
A new complement factor B mutation associated with crescentic C3 glomerulopathy; a case report [PDF]
Background: C3 glomerulopathy is a recently described entity classified as complementassociated glomerular disease. Case Presentation: We report a case of a 48-year-old man referred to the nephrology department for nephrotic syndrome with rapidly ...
Sofia Semedo Coelho +10 more
doaj +1 more source
Pathology of C3 Glomerulopathy [PDF]
C3 glomerulopathy is a renal disorder involving dysregulation of alternative pathway complement activation. In most instances, a membranoproliferative pattern of glomerular injury with a prevalence of C3 deposition is observed by immunofluorescence ...
Su-Jin Shin, Yoonje Seong, Beom Jin Lim
doaj +1 more source
Eculizumab as a treatment for C3 glomerulopathy: a single-center retrospective study
Background C3 Glomerulopathy (C3G) is a rare glomerular disease caused by dysregulation of the complement pathway. Based on its pathophysiology, treatment with the monoclonal antibody eculizumab targeting complement C5 may be a therapeutic option. Due to
Thomas Welte +6 more
doaj +1 more source
Remissions and progression of C3 glomerulopathy
Aim. To analyze the outcomes of C3-glomerulopathy (C3-GP) and determine the associated factors. Materials and methods. A retrospective single-center study included 60 patients with newly diagnosed C3-GP (with primary C3-GP pC3-GP 82%). Of these, 48 (
Anna V. Karunnaya +1 more
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Dense deposit disease associated with monoclonal gammopathy of undetermined significance. [PDF]
Sethi S +8 more
europepmc +2 more sources
Complement Factor I Variants in Complement-Mediated Renal Diseases
C3 glomerulopathy (C3G) and atypical hemolytic uremic syndrome (aHUS) are two rare diseases caused by dysregulated activity of the alternative pathway of complement secondary to the presence of genetic and/or acquired factors. Complement factor I (FI) is
Yuzhou Zhang +12 more
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