Results 11 to 20 of about 16,816 (256)

Eculizumab in Pediatric Dense Deposit Disease. [PDF]

Clin J Am Soc Nephrol, 2015
Dense deposit disease (DDD), a subtype of C3 glomerulopathy, is a rare disease affecting mostly children. Treatment options are limited. Debate exists whether eculizumab, a monoclonal antibody against complement factor C5, is effective in DDD. Reported data are scarce, especially in children.The authors analyzed clinical and histologic data of five ...
Oosterveld MJ, Garrelfs MR, Hoppe B, Florquin S, Roelofs JJ, van den Heuvel LP, Amann K, Davin JC, Bouts AH, Schriemer PJ, Groothoff JW.   +10 more
europepmc   +8 more sources

Favorable effect of bortezomib in dense deposit disease associated with monoclonal gammopathy: a case report [PDF]

BMC Nephrology, 2018
Background Complement component 3 (C3) glomerulopathy, which includes dense deposit disease (DDD) and C3 glomerulonephritis, is caused by dysregulation of the alternative complement pathway.
Shuma Hirashio, Ayaka Satoh, Takahiro Arima, Kouichi Mandai, Tadasuke Awaya, Kumi Oshima, Shigeo Hara, Takao Masaki   +7 more
doaj   +4 more sources

New approaches to the treatment of dense deposit disease. [PDF]

J Am Soc Nephrol, 2007
The development of clinical treatment protocols usually relies on evidence-based guidelines that focus on randomized, controlled trials. For rare renal diseases, such stringent requirements can represent a significant challenge. Dense deposit disease (DDD; also known as membranoproliferative glomerulonephritis type II) is a prototypical rare disease ...
Smith RJ, Alexander J, Barlow PN, Botto M, Cassavant TL, Cook HT, de Córdoba SR, Hageman GS, Jokiranta TS, Kimberling WJ, Lambris JD, Lanning LD, Levidiotis V, Licht C, Lutz HU, Meri S, Pickering MC, Quigg RJ, Rops AL, Salant DJ, Sethi S, Thurman JM, Tully HF, Tully SP, van der Vlag J, Walker PD, Würzner R, Zipfel PF, Dense Deposit Disease Focus Group.   +28 more
europepmc   +7 more sources

Dense deposit disease: clinicopathologic study of 32 pediatric and adult patients. [PDF]

Clin J Am Soc Nephrol, 2009
Dense deposit disease (DDD) is a rare disorder that most commonly affects children. This study reports the largest North American series addressing clinicopathologic and outcome differences in children and adults.Thirty-two patients with DDD were analyzed from the archives of Columbia University between 1977 and 2007.
Nasr SH, Valeri AM, Appel GB, Sherwinter J, Stokes MB, Said SM, Markowitz GS, D'Agati VD.   +7 more
europepmc   +5 more sources

Dense deposit disease is not a membranoproliferative glomerulonephritis [PDF]

Modern Pathology, 2007
Dense deposit disease (first reported in 1962) was classified as subtype II of membranoproliferative glomerulonephritis in the early 1970s. Over the last 30 years, marked differences in etiology and pathogenesis between type I membranoproliferative glomerulonephritis and dense deposit disease have become apparent.
Patrick D Walker, Franco Ferrario, Kensuke Joh   +2 more
exaly   +4 more sources

Case report: a rare concurrence of dense deposit disease in an adolescent patient with IgA nephropathy [PDF]

BMC Pediatrics
Background Dense deposit disease (DDD) is a rare renal disorder major affecting adolescents and children, characterized by an absence of distinctive clinical symptoms.
Jian-Hui Zhang, Hong-Ping Yu, Ying Chen, Qian Chen, Xiao-Ling Zheng, Jie-Wei Luo, Li Zhang   +6 more
doaj   +2 more sources

Anti-factor H antibody affecting factor H cofactor activity in a patient with dense deposit disease. [PDF]

Clin Kidney J, 2012
4 p.-2 fig.Complement alternative pathway dysregulation seems to be the pathophysiological basis of Dense Deposit Disease (DDD). Here, we describe a monoclonal anti-factor H (FH) autoantibody in a woman diagnosed with DDD with a monoclonal gammapathy ...
Nozal P, Strobel S, Ibernon M, López D, Sánchez-Corral P, Rodríguez de Córdoba S, Józsi M, López-Trascasa M.   +7 more
europepmc   +3 more sources

Dense deposit disease in a child with febrile sore throat

Saudi Journal of Kidney Diseases and Transplantation, 2017
Dense deposit disease or membranoproliferative glomerulonephritis type II is a rare glomerulopathy characterized on renal biopsy by deposition of abnormal electron-dense material in the glomerular basement membrane.
Giovanni Conti, Dominique De Vivo, Agata Vitale, Carmelo Fede, Domenico Santoro   +4 more
doaj   +1 more source

A case of regression of atypical dense deposit disease without C3 deposition in a child [PDF]

Korean Journal of Pediatrics, 2010
Dense deposit disease (DDD) is a rare disorder characterized by the deposition of abnormal electron-dense material within the glomerular basement membrane of the kidneys. The diagnosis is made in most patients between 5 and 15 years of age, and within 10
Min Sun Kim, Pyoung Han Hwang, Mung Jae Kang, Dae-Yeol Lee   +3 more
doaj   +2 more sources

Eculizumab for dense deposit disease and C3 glomerulonephritis. [PDF]

Clin J Am Soc Nephrol, 2012
Summary Background and objectives The principle defect in dense deposit disease and C3 glomerulonephritis is hyperactivity of the alternative complement pathway. Eculizumab, a monoclonal antibody that binds to C5 to prevent formation of the membrane attack complex, may prove beneficial.
Bomback AS, Smith RJ, Barile GR, Zhang Y, Heher EC, Herlitz L, Stokes MB, Markowitz GS, D'Agati VD, Canetta PA, Radhakrishnan J, Appel GB.   +11 more
europepmc   +4 more sources