Results 21 to 30 of about 16,635 (234)

A new complement factor B mutation associated with crescentic C3 glomerulopathy; a case report [PDF]

Journal of Nephropathology, 2019
Background: C3 glomerulopathy is a recently described entity classified as complementassociated glomerular disease. Case Presentation: We report a case of a 48-year-old man referred to the nephrology department for nephrotic syndrome with rapidly ...
Sofia Semedo Coelho, Ana Raquel Fernandes, Elsa Soares, Patrícia Valério, Bruno Matos, Helena Romão, Mário Góis, Helena Sousa, Teresa Fidalgo, Ana Sofia Natário, Carlos Barreto   +10 more
doaj   +1 more source

Pathology of C3 Glomerulopathy [PDF]

Childhood Kidney Diseases, 2019
C3 glomerulopathy is a renal disorder involving dysregulation of alternative pathway complement activation. In most instances, a membranoproliferative pattern of glomerular injury with a prevalence of C3 deposition is observed by immunofluorescence ...
Su-Jin Shin, Yoonje Seong, Beom Jin Lim
doaj   +1 more source

Dense Deposit Disease Associated With Monoclonal Gammopathy of Undetermined Significance [PDF]

American Journal of Kidney Diseases, 2010
Sanjeev Sethi, Lynn Cornell, Yuzhou Zhang   +2 more
exaly   +2 more sources

Eculizumab as a treatment for C3 glomerulopathy: a single-center retrospective study

BMC Nephrology, 2023
Background C3 Glomerulopathy (C3G) is a rare glomerular disease caused by dysregulation of the complement pathway. Based on its pathophysiology, treatment with the monoclonal antibody eculizumab targeting complement C5 may be a therapeutic option. Due to
Thomas Welte, Frederic Arnold, Lukas Westermann, Felix A. Rottmann, Martin J. Hug, Elke Neumann-Haefelin, Athina Ganner   +6 more
doaj   +1 more source

Remissions and progression of C3 glomerulopathy

Терапевтический архив, 2022
Aim. To analyze the outcomes of C3-glomerulopathy (C3-GP) and determine the associated factors. Materials and methods. A retrospective single-center study included 60 patients with newly diagnosed C3-GP (with primary C3-GP pC3-GP 82%). Of these, 48 (
Anna V. Karunnaya, Vladimir A. Dobronravov   +1 more
doaj   +1 more source

Anti-factor H antibody affecting factor H cofactor activity in a patient with dense deposit disease [PDF]

CKJ: Clinical Kidney Journal, 2012
Santiago Rodríguez de Cordoba, Margarita Lopez-Trascasa, Mihály Jozsi   +2 more
exaly   +2 more sources

Complement Factor I Variants in Complement-Mediated Renal Diseases

Frontiers in Immunology, 2022
C3 glomerulopathy (C3G) and atypical hemolytic uremic syndrome (aHUS) are two rare diseases caused by dysregulated activity of the alternative pathway of complement secondary to the presence of genetic and/or acquired factors. Complement factor I (FI) is
Yuzhou Zhang, Renee X. Goodfellow, Nicolo Ghiringhelli Borsa, Hannah C. Dunlop, Stephen A. Presti, Nicole C. Meyer, Dingwu Shao, Sarah M. Roberts, Michael B. Jones, Gabriella R. Pitcher, Amanda O. Taylor, Carla M. Nester, Richard J. H. Smith   +12 more
doaj   +1 more source

Rare Case of C3 Glomerulopathy in a Patient of Type 1 Diabetes Mellitus

Saudi Journal of Kidney Diseases and Transplantation, 2022
Complement component 3 glomerulopathy (C3G) is a recently defined entity comprising dense deposit disease and C3 glomerulonephritis. It is associated with nonrenal diseases such as diabetes mellitus (DM) type 1, ocular drusen, acquired partial ...
Suraj Godara, Karan Kumar Saraf
doaj   +1 more source

Diverse Clinical Presentations of C3 Dominant Glomerulonephritis

Frontiers in Medicine, 2020
C3 dominant immunofluorescence staining is present in a subset of patients with idiopathic immune complex membranoproliferative glomerulonephritis (iMPGN).
Ramy M. Hanna, Ramy M. Hanna, Jean Hou, Huma Hasnain, Farid Arman, Umut Selamet, Umut Selamet, James Wilson, Samuel Olanrewaju, Jonathan E. Zuckerman, Marina Barsoum, Julie M. Yabu, Ira Kurtz, Ira Kurtz   +13 more
doaj   +1 more source

Treating C3 glomerulopathy with eculizumab

BMC Nephrology, 2018
Background C3 glomerulopathy (C3G) is a rare, but severe glomerular disease with grim prognosis. The complex pathogenesis is just unfolding, and involves acquired as well as inherited dysregulation of the alternative pathway of the complement cascade ...
Thomas Welte, Frederic Arnold, Julia Kappes, Maximilian Seidl, Karsten Häffner, Carsten Bergmann, Gerd Walz, Elke Neumann-Haefelin   +7 more
doaj   +1 more source