Results 21 to 30 of about 5,589,445 (235)

Rare Case of C3 Glomerulopathy in a Patient of Type 1 Diabetes Mellitus

Saudi Journal of Kidney Diseases and Transplantation, 2022
Complement component 3 glomerulopathy (C3G) is a recently defined entity comprising dense deposit disease and C3 glomerulonephritis. It is associated with nonrenal diseases such as diabetes mellitus (DM) type 1, ocular drusen, acquired partial ...
Suraj Godara, Karan Kumar Saraf
doaj   +1 more source

Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY. [PDF]

, 2010
The unparalleled collection of clinical data and biomaterials within the EHDN's REGISTRY can expedite the search for disease modifiers (genetic and environmental) of age at onset and disease progression that could be harnessed for the development of ...
Handley, Olivia J, Landwehrmeyer, G Bernhard, Aileen K Ho, Bisson, Jonathan Ian, Schwenke C, David Craufurd, Dunnett, Stephen B., Handley, Olivia, Investigators of the European Huntington's Disease Network, The, DI MARIA, EMILIO, Craufurd D, Dunnett, SB, Carsten Schwenke, the investigators of the European Huntington's Disease Network, Craufurd, David, Edward Wild, Landwehrmeyer, GB, Busse, Monica, Rosser, Anne Elizabeth, Olivia J Handley, Romano Silvia., Tabrizi SJ, Ho, Aileen K., Wild, E, Landwehrmeyer GB, Craufurd, D, Tabrizi, SJ, Tabrizi, Sarah J., Handley, OJ, Rickards, Hugh, Dunnett, Stephen, Ho, Aileen K, Orth, Michael, Ho, AK, Wild, Edward, Stephen B. Dunnett, Sarah J Tabrizi, Wild, EJ, Landwehrmeyer, G. Bernhard, Naji, Jenny, Landwehrmeyer, G. Bernhard, Wild E, Investigators of the European Huntington's Disease Network, Handley, Olivia J., Orth, M, Ellison-Rose, Lynda, Tabrizi, Sarah J, Price, Kathleen, Ho AK, ABBRUZZESE, GIOVANNI, Schwenke, C, Ho, A, Orth M, Handley OJ, Schwenke, Carsten, Dunnett SB, Dunnett, Stephen B, Michael Orth, G. Bernhard Landwehrmeyer   +59 more
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Treating C3 glomerulopathy with eculizumab

BMC Nephrology, 2018
Background C3 glomerulopathy (C3G) is a rare, but severe glomerular disease with grim prognosis. The complex pathogenesis is just unfolding, and involves acquired as well as inherited dysregulation of the alternative pathway of the complement cascade ...
Thomas Welte, Frederic Arnold, Julia Kappes, Maximilian Seidl, Karsten Häffner, Carsten Bergmann, Gerd Walz, Elke Neumann-Haefelin   +7 more
doaj   +1 more source

Diverse Clinical Presentations of C3 Dominant Glomerulonephritis

Frontiers in Medicine, 2020
C3 dominant immunofluorescence staining is present in a subset of patients with idiopathic immune complex membranoproliferative glomerulonephritis (iMPGN).
Ramy M. Hanna, Ramy M. Hanna, Jean Hou, Huma Hasnain, Farid Arman, Umut Selamet, Umut Selamet, James Wilson, Samuel Olanrewaju, Jonathan E. Zuckerman, Marina Barsoum, Julie M. Yabu, Ira Kurtz, Ira Kurtz   +13 more
doaj   +1 more source

Dense intramembranous deposit disease: New pathologic features [PDF]

, 1984
Dense intramembranous deposit disease: New pathologic features. The pathologic and clinical features of 16 patients with dense intramembranous deposit disease are described.
Sibley, Richard K., Kim, Youngki
core   +1 more source

Diagnostic and therapeutic challenges in dense deposit disease: case report [PDF]

We report a complex case of a 15-year-old girl initially diagnosed with post-streptococcal glomerulonephritis (PSGN) but later identified as having dense deposit disease, which was initially classified as type 2 membranoproliferative glomerulonephritis ...
Harsha Shahi, Anand Prasad, Dhruv Jain, Navya Jaiswal   +3 more
core   +1 more source

Regulating complement in the kidney: insights from CFHR5 nephropathy

Disease Models & Mechanisms, 2011
Complement factor H related protein 5 (CFHR5) nephropathy is a monogenic disorder of complement regulation that is endemic in Cyprus. The disease is characterised by haematuria, C3 glomerulonephritis and kidney failure. Its identification suggests a role
Daniel P. Gale, Matthew C. Pickering
doaj   +1 more source

H deficiency in two brothers with atypical dense intramembranous deposit disease [PDF]

, 1986
H deficiency in two brothers with atypical dense intramembranous deposit disease. We report an H deficiency in two Algerian brothers who had early–onset glomerulonephritis. In addition, one suffered from serious lung infections.
Philippe Lesavre, Hauptmann, Georges, Patrick Niaudet, Georges Hauptmann, Niaudet, Patrick, Abdelatif Bensenouci, Bensenouci, Abdelatif, Marie–Claire Gubler, Halbwachs–Mecarelli, Lise, Micheline Levy, Gérard Kohout, Levy, Micheline, Lise Halbwachs–Mecarelli, Gubler, Marie–Claire, Kohout, Gérard, Lesavre, Philippe   +15 more
core   +1 more source

Gain of function mutant of complement factor B K323E mimics pathogenic C3NeF autoantibodies in convertase assays

Autoimmunity, 2018
Complement convertases are enzymatic complexes, which play a critical role in propagation and amplification of the complement cascade. Under physiological conditions, convertases decay shortly after being formed in either spontaneous or inhibitor-driven ...
Aleksandra Urban, Anna Borowska, Anna Felberg, Lambertus van den Heuvel, Grzegorz Stasiłojć, Elena Volokhina, Marcin Okrój   +6 more
doaj   +1 more source

Complement-Mediated Glomerular Diseases: A Tale of 3 Pathways

Kidney International Reports, 2016
A renewed interest in the role of complement in the pathogenesis of glomerular diseases has improved our understanding of their basic, underlying physiology.
Andrew S. Bomback, Glen S. Markowitz, Gerald B. Appel   +2 more
doaj   +1 more source