Results 21 to 30 of about 62,552 (281)

Eculizumab as a treatment for C3 glomerulopathy: a single-center retrospective study

BMC Nephrology, 2023
Background C3 Glomerulopathy (C3G) is a rare glomerular disease caused by dysregulation of the complement pathway. Based on its pathophysiology, treatment with the monoclonal antibody eculizumab targeting complement C5 may be a therapeutic option. Due to
Thomas Welte, Frederic Arnold, Lukas Westermann, Felix A. Rottmann, Martin J. Hug, Elke Neumann-Haefelin, Athina Ganner   +6 more
doaj   +1 more source

Remissions and progression of C3 glomerulopathy

Терапевтический архив, 2022
Aim. To analyze the outcomes of C3-glomerulopathy (C3-GP) and determine the associated factors. Materials and methods. A retrospective single-center study included 60 patients with newly diagnosed C3-GP (with primary C3-GP pC3-GP 82%). Of these, 48 (
Anna V. Karunnaya, Vladimir A. Dobronravov   +1 more
doaj   +1 more source

Complement C3 variant and the risk of age-related macular degeneration [PDF]

, 2007
Background: Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors.
Armbrecht, AM, Bird, AC, Clayton, DG, Deary, IJ, Dhillon, B, Genetic Factors AMD Study G, Hayward, C, Khan, JC, Matharu, BK, Moore, AT, Morgan, J, Redmond, E, Sepp, T, Shahid, H, Thurlby, DA, Wright, AF, Yates, JRW   +16 more
core   +1 more source

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M, Kishore, U, Kouser, L, Nayak, A, Sim, RB, Stover, CM   +5 more
core   +1 more source

Complement Factor I Variants in Complement-Mediated Renal Diseases

Frontiers in Immunology, 2022
C3 glomerulopathy (C3G) and atypical hemolytic uremic syndrome (aHUS) are two rare diseases caused by dysregulated activity of the alternative pathway of complement secondary to the presence of genetic and/or acquired factors. Complement factor I (FI) is
Yuzhou Zhang, Renee X. Goodfellow, Nicolo Ghiringhelli Borsa, Hannah C. Dunlop, Stephen A. Presti, Nicole C. Meyer, Dingwu Shao, Sarah M. Roberts, Michael B. Jones, Gabriella R. Pitcher, Amanda O. Taylor, Carla M. Nester, Richard J. H. Smith   +12 more
doaj   +1 more source

Dense deposit disease associated with monoclonal gammopathy of undetermined significance. [PDF]

Am J Kidney Dis, 2010
Sethi S, Sukov WR, Zhang Y, Fervenza FC, Lager DJ, Miller DV, Cornell LD, Krishnan SG, Smith RJ.   +8 more
europepmc   +2 more sources

Cosmetic Talc-Related Pulmonary Granulomatosis. [PDF]

, 2017
Inhalation of cosmetic talc can lead to pulmonary foreign-body granulomatosis, though fewer than 10 cases of inhaled cosmetic talc-related pulmonary granulomatosis have been reported in adults.
Adams, Jason Y, Jasuja, Sonia, Kuhn, Brooks T, Schivo, Michael   +3 more
core   +1 more source

Dietary fatty acids and lipoproteins on progression of age-related macular degeneration [PDF]

, 2017
Age-related macular degeneration (AMD) is a medical condition of central loss vision and blindness. Numerous studies have revealed that changes on certain dietary fatty acids (FAs) could have useful for AMD management.
Abia González, María del Rocío, Bermúdez Pulgarín, Beatriz, García Muriana, Francisco José, López Martín, Sergio, Montserrat de la Paz, Sergio, Naranjo Gutiérrez, María del Carmen   +5 more
core   +3 more sources

Rare Case of C3 Glomerulopathy in a Patient of Type 1 Diabetes Mellitus

Saudi Journal of Kidney Diseases and Transplantation, 2022
Complement component 3 glomerulopathy (C3G) is a recently defined entity comprising dense deposit disease and C3 glomerulonephritis. It is associated with nonrenal diseases such as diabetes mellitus (DM) type 1, ocular drusen, acquired partial ...
Suraj Godara, Karan Kumar Saraf
doaj   +1 more source

Iron Age to Medieval entomogamous vegetation and Rhinolophus hipposideros roost in south-eastern Wales (UK) [PDF]

, 2006
Karst cave systems are well developed in Wales (UK) and, in some instances, constitute important bat roosts. Ogof Draenen, near Blaenavon in south-east Wales, is the most recent major cave discovery (1994) with already > 70 km of passages explored ...
Bronk, Bui-Thi, Camacho, Carbonnel, Carbonnel, Carrión, Chambers, Chambers, Coles, Herrera, Jegla, Maher, Maher, Michael J. Simms, Pendleton, Proctor, Rosen, Simms, Simms, Smith, Stuiver, Suzanne A.G. Leroy, Vaughan, Waltham, Warren   +24 more
core   +1 more source