Results 51 to 60 of about 243,843 (158)

The Src‐Family Kinases Hck, Fgr and Lyn Drive Immune Complex‐Mediated Glomerulonephritis Through the Syk Tyrosine Kinase

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
The study aimed to test the role of three Src‐family kinases, Hck, Fgr, and Lyn in immune complex glomerulonephritis. Hck, Fgr, and Lyn were overexpressed in human lupus nephritis and mouse nephrotoxic nephritis. Combined genetic deficiency of the three kinases practically completely protected mice from nephrotoxic nephritis.
Lukács S. Lesinszki, Dorottya Deli, Lili K. Boldizsár, Áron Pánczél, Attila Fintha, Michael G. Robson, Attila Mócsai   +6 more
wiley   +1 more source

Cutaneous IgA Vasculitis in Primary Sjögren Disease: Findings From a Medical Record–Based Review

ACR Open Rheumatology, Volume 8, Issue 7, July 2026.
Objective This study aimed to describe clinical observations of patients presenting with palpable purpura, which is suspected to represent IgA vasculitis (IgAV) based on direct immunofluorescence (DIF), who were ultimately diagnosed with cutaneous vasculitis associated with primary Sjögren disease (SjD).
Shay Brikman, Mohammad Egbaria, Amir Bieber   +2 more
wiley   +1 more source

A case of glomerulonephritis with dominant C3 with organized deposits complicated by non-tuberculous mycobacteria

Human Pathology Reports
We report a case of membranoproliferative glomerulonephritis (MPGN) with dominant C3 and uniquely organized deposits complicated by pulmonary non-tuberculous mycobacterial (NTM) infection.
Masanori Sudo, Chihiro Sakurazawa, Yuichi Sakamaki, Masato Habuka, Asa Ogawa, Yumi Ito, Naofumi Imai, Sayuri Takamura, Satoshi Ito, Akira Shimizu, Shin Goto, Suguru Yamamoto   +11 more
doaj   +1 more source

C4 nephritic factor in patients with immune-complex-mediated membranoproliferative glomerulonephritis and C3-glomerulopathy

Orphanet Journal of Rare Diseases, 2019
Background Acquired or genetic abnormalities of the complement alternative pathway are the primary cause of C3glomerulopathy(C3G) but may occur in immune-complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) as well. Less is known about the
Nóra Garam, Zoltán Prohászka, Ágnes Szilágyi, Christof Aigner, Alice Schmidt, Martina Gaggl, Gere Sunder-Plassmann, Dóra Bajcsi, Jürgen Brunner, Alexandra Dumfarth, Daniel Cejka, Stefan Flaschberger, Hana Flögelova, Ágnes Haris, Ágnes Hartmann, Andreas Heilos, Thomas Mueller, Krisztina Rusai, Klaus Arbeiter, Johannes Hofer, Dániel Jakab, Mária Sinkó, Erika Szigeti, Csaba Bereczki, Viktor Janko, Kata Kelen, György S. Reusz, Attila J. Szabó, Nóra Klenk, Krisztina Kóbor, Nika Kojc, Maarten Knechtelsdorfer, Mario Laganovic, Adrian Catalin Lungu, Anamarija Meglic, Rina Rus, Tanja Kersnik-Levart, Ernesta Macioniene, Marius Miglinas, Anna Pawłowska, Tomasz Stompór, Ludmila Podracka, Michael Rudnicki, Gert Mayer, Romana Rysava, Jana Reiterova, Marijan Saraga, Tomáš Seeman, Jakub Zieg, Eva Sládková, Tamás Szabó, Andrei Capitanescu, Simona Stancu, Miroslav Tisljar, Kresimir Galesic, András Tislér, Inga Vainumäe, Martin Windpessl, Tomas Zaoral, Galia Zlatanova, Dorottya Csuka   +60 more
doaj   +1 more source

A Combined Transcriptomics and Proteomics Approach to Identify Immune Signatures in ANCA‐Associated Glomerulonephritis

ACR Open Rheumatology, Volume 8, Issue 7, July 2026.
Objective Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis often leads to severe kidney damage. To better understand ANCA‐associated glomerulonephritis (AAGN) and identify potential new therapeutic targets, we performed comprehensive transcriptomic and compartmental proteomic analysis of kidney biopsies from 23 patients in the ...
Ivana Stojkic, John P. Shapiro, Arnon Arazi, Huijuan Song, Pearlly Yan, Estela Puchulu‐Campanella, Hubao Wang, William E. Smoyer, Lynn A. Fussner, Anjali Satoskar, Xin Wang, Samir V. Parikh, Stacy P. Ardoin, Dan Koboldt, Brad H. Rovin, Salem Almaani   +15 more
wiley   +1 more source

Animal models of idiopathic membranous nephropathy: Recent advances and future perspectives

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1325-1337, July 2026.
This review focuses on the evolution of idiopathic membranous nephropathy (IMN) animal models from traditional approaches (Heymann nephritis, C‐BSA, APA) to antigen‐specific models (PLA2R, THSD7A), critically evaluating their advances and limitations in replicating human IMN pathology.
Qiuying Liu, Huixian Bian, Jianhua Liu, Lina Wu, Zhijie Zhang, Hongli Zhao, Xiaosong Qin   +6 more
wiley   +1 more source

C3 glomerulonephritis; a rare complication of CLL

, 2020
Kidney disease develops in chronic lymphocytic leukemia (CLL) patients via multiple mechanisms including infiltration, obstruction, tumor lysis syndrome, and glomerular disease.
Srour, Khaled M, Lakshmikanth, Jayanth, Chitturi, Chandrika, Faber, Mark D   +3 more
core   +2 more sources

Unusual Bullous Manifestation of Scabies in Childhood Diagnosed by Dermoscopy: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Scabies is a common ectoparasitic infestation, but atypical variants such as bullous scabies are rare and often misdiagnosed. We report a 12‐year‐old boy who presented with pruritic lesions comprising predominantly vesicles and bullae over the hands, along with a few scattered excoriated papules on the trunk and thighs.
Anupa Khadka, Vikash Paudel
wiley   +1 more source

Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Excessive complement activation is implicated in a broad range of diseases. Therapeutic approaches targeting the complement cascade, from pathway‐selective inhibition to terminal blockade, can effectively control disease activity. However, increasing degrees of complement inhibition are associated with a heightened susceptibility to bacterial, viral ...
Serena Bettoni, Ebba Qviberg, Edward Chaloner, Hayley Lavender, Maisem Laabei   +4 more
wiley   +1 more source

Outcomes and Predictors of Acute Post‐Streptococcal Glomerulonephritis in Hospitalized Children in Northwest Ethiopia: A Multicenter Retrospective Cohort Study

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background Acute post‐streptococcal glomerulonephritis (APSGN) is one of the most critical health conditions. It remains an important cause of acute kidney injury, hospitalization, and long‐term complications for children. Thus, this study aimed to assess the treatment outcome of APSGN and its predictors among pediatric patients at ...
Tilaye Arega Moges, Samuel Berihun Dagnew, Yibeltal Tilaye Yayeh, Samuel Agegnew Wondm, Fisseha Nigussie Dagnew, Getachew Yitayew Tarekegn, Mekdes Kiflu, Asres Agegnehu Worku, Mulugeta Ashagrie Bekahagn, Kale Gubae   +9 more
wiley   +1 more source