Results 51 to 60 of about 217,483 (203)

Eculizumab for dense deposit disease and C3 glomerulonephritis. [PDF]

Clinical Journal of the American Society of Nephrology, 2012
Summary Background and objectives The principle defect in dense deposit disease and C3 glomerulonephritis is hyperactivity of the alternative complement pathway. Eculizumab, a monoclonal antibody that binds to C5 to prevent formation of the membrane attack complex, may prove beneficial.
A. Bomback, Richard J. H. Smith, G. Barile, Yuzhou Zhang, Eliot C Heher, L. Herlitz, M. Stokes, G. Markowitz, V. D’Agati, P. Canetta, J. Radhakrishnan, G. Appel   +11 more
semanticscholar   +3 more sources

Clinico-Pathogenic Similarities and Differences between Infection-Related Glomerulonephritis and C3 Glomerulopathy

, 2023
Recently, the comprehensive concept of “infection-related glomerulonephritis (IRGN)” has replaced that of postinfectious glomerulonephritis (PIGN) because of the diverse infection patterns, epidemiology, clinical features, and pathogenesis ...
Kazuhiro Takeuchi, Mariko Kamata, Togo Aoyama, Yasuo Takeuchi, Tetsuya Abe, Yukihiro Wada, Sayumi Kawamura, Takashi Oda, Ryoma Miyasaka   +8 more
core   +1 more source

Regulating complement in the kidney: insights from CFHR5 nephropathy

Disease Models & Mechanisms, 2011
Complement factor H related protein 5 (CFHR5) nephropathy is a monogenic disorder of complement regulation that is endemic in Cyprus. The disease is characterised by haematuria, C3 glomerulonephritis and kidney failure. Its identification suggests a role
Daniel P. Gale, Matthew C. Pickering
doaj   +1 more source

Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance

, 2010
Complement activation is known to have deleterious effects on organ transplantation. On the other hand, the complement system is also known to have an important role in regulating immune responses.
Cook, T, Derbyshire, Katy, Dyson, Julian, Cook, Terence, Chai, JG, Coe, D, Scott, Diane, Dumitriu, IE, Baruah, Paramita, Coe, David, Dumitriu, Ingrid E; id_orcid, Dyson, J, Baruah, P, Derbyshire, K, Simpson, Elizabeth, Botto, Marina, Addey, C, Scott, D, Addey, Caroline, Botto, M, Chai, Jian-Guo, Simpson, E   +21 more
core   +1 more source

C4d at Crossroads Between Post-Infectious Glomerulonephritis and C3 Glomerulopathy

International Journal of Nephrology and Renovascular Disease, 2021
Shaarif Bashir,1 Mudassar Hussain,1 Aurangzeb Afzal,2 Usman Hassan,1 Maryam Hameed,1 Sajid Mushtaq1 1Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, 54000, Pakistan; 2Department of Nephrology, Lahore General ...
Bashir S, Hussain M, Afzal A, Hassan U, Hameed M, Mushtaq S   +5 more
doaj  

Concurrent Acute Glomerulonephritis and Retropharyngeal Abscess in 10 Year Boy: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2017
Postinfectious Glomerulonephritis (PIGN) usually follows 1-2 weeks after respiratory tract infection and 4-6 weeks after skin infection. Acute Glomerulonephritis (AGN) is uncommon with simultaneous severe throat infections. We describe a 10-year-old boy
Sudha Yadav, Deepali Garg, Narain Das Vaswani, Jaya Shankar Kaushik, Seema Rohilla   +4 more
doaj   +1 more source

Glomerular C4d deposition in proliferative glomerular diseases

Indian Journal of Pathology and Microbiology, 2021
Introduction: The aim of this study was to evaluate the immunohistochemical expression of C4d in native renal biopsies of proliferative glomerular diseases, complement pathways in these diseases, and assess the relationship of C4d with histological and ...
Sarojini Raman, Pallavi Mishra, Ansuman Panigrahi, Nikunj K Rout, Kanakalata Dash   +4 more
doaj   +1 more source

#627 C3 glomerulonephritis and C3-dominant infection related glomerulonephritis—are they similar?

Nephrology Dialysis Transplantation
Abstract Background C3 glomerulonephritis (C3GN) and C3 dominant infection related glomerulonephritis (C3-IRGN) comprise two important immune complex mediated diseases. C3GN is caused by dysregulation of the alternate pathway by congenital or acquired abnormalities in the complement pathway.
Mythri Shankar, Ranjitha Siddalingappa, Sreedhara C.G., Kishan A., Karthik Tenannkore   +4 more
openaire   +1 more source

Immune complex glomerulonephritis in C4- and C3-deficient mice

, 1998
Immune complex glomerulonephritis in C4- and C3-deficient mice. In this study, we examined the roles of C4 and C3 in immune complex glomerulonephritis by actively immunizing C4-deficient (C4 –/–), C3 deficient (C3 –/–) and wild-type mice with apoferritin.
Alexander, Jessy J., Chun He, Carroll, Michael C., Mark Haas, Richard J. Quigg, Alice Lim, Jessy J. Alexander, Michael C. Carroll, Haas, Mark, He, Chun, Quigg, Richard J., Lim, Alice   +11 more
core   +1 more source

Unmasking the C3ulprit

Graduate Medical Education Research Journal, 2023
Mentor: Prasanth Ravipati Program: Nephrology Type: Case Report Background: C3 glomerulonephritis (C3GN) is a rare disease with pathology findings typically showing a proliferative pattern with C3 deposition on immunofluorescence (IF) and negative ...
Audai Maayah, Brian Benes, Kathleen Borghoff, Kirk Foster, Prasanth Ravipati   +4 more
doaj   +1 more source