Results 61 to 70 of about 18,807 (198)
Pathology of C3 Glomerulonephritis
Journal of the Korean Society of Pediatric Nephrology, 2013 사구체에 면역글로불린은 음성이면서 C3 만 침착되는 경우, 다른 원인이 없는 경우 C3GN을 의심하여야 한다. 광학현미경으로는 세포의 증식이 있는 경우와 없는 경우가 있지만, 전자현미경으로는 EDD가 내피세포 밑으로 혹은 메산지움 등에 침착함을 확인하여야 한다. 대체보체경로의 조절이상이 원인임으로 혈청 C3 치를 비롯하여 CFH, CFI, CFB 등을 측정하여야 하며, C3 nephritic factor, anti-factor H 자가항체 등을 조사하는 것이 필요하다. 보체 조절이상을 일으키는 유전자 돌연변이를 조사해 보아야 한다. 예후는 안정적이지만, 치료는 대증적이다.
openaire +1 more source
Retinal findings in glomerulonephritis [PDF]
, 2022 The complement system is part of the innate immune system activated by three distinct pathways: classical, lectin and alternative. It is also involved in retinal development and homoeostasis.
Colville D. J. +5 more
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Graduate Medical Education Research Journal, 2023 Mentor: Prasanth Ravipati Program: Nephrology Type: Case Report Background: C3 glomerulonephritis (C3GN) is a rare disease with pathology findings typically showing a proliferative pattern with C3 deposition on immunofluorescence (IF) and negative ...
Audai Maayah +4 more
doaj +1 more source
Frontiers in Immunology, 2021 Recombinant human factor H (hFH) has potential for treating diseases linked to aberrant complement regulation including C3 glomerulopathy (C3G) and dry age-related macular degeneration.
Heather Kerr +18 more
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ACR Open Rheumatology, Volume 8, Issue 7, July 2026.Objective Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis often leads to severe kidney damage. To better understand ANCA‐associated glomerulonephritis (AAGN) and identify potential new therapeutic targets, we performed comprehensive transcriptomic and compartmental proteomic analysis of kidney biopsies from 23 patients in the ...
Ivana Stojkic +15 more
wiley +1 more source
Durable remission of C3 glomerulonephritis with mycophenolate mofetil [PDF]
Nephrology, 2017 AbstractIn C3 glomerulopathy, uncontrolled complement C3 activation via the alternative pathway results in glomerular C3 deposition and, in many cases, progressive renal failure. Despite advances in understanding of C3G pathogenesis over the last few years, there are no proven treatments.
Nicole, Lioufas +2 more
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De novo C3 glomerulonephritis in a renal allograft [PDF]
, 2017 C3 glomerulonephritis (C3GN) is a recently described, rare glomerular disease characterized by predominant or sole glomerular C3 deposits. Morphologic features of C3GN are similar to those of dense deposit disease (DDD); however, ribbon-like ...
임범진 +4 more
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Animal models of idiopathic membranous nephropathy: Recent advances and future perspectives
Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1325-1337, July 2026.This review focuses on the evolution of idiopathic membranous nephropathy (IMN) animal models from traditional approaches (Heymann nephritis, C‐BSA, APA) to antigen‐specific models (PLA2R, THSD7A), critically evaluating their advances and limitations in replicating human IMN pathology.
Qiuying Liu +6 more
wiley +1 more source
Plasma C3 and C4 Concentrations in Management of Glomerulonephritis [PDF]
BMJ, 1973 As part of a larger study of serial complement profiles in glomerulonephritis plasma C3 and C4 concentrations were measured using commercially available immunodiffusion plates. A total of 303 samples were obtained from 128 patients suffering from forms of nephritis associated with hypocomplementaemia—namely, lupus nephritis, mesangiocapillary ...
J S, Cameron +5 more
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C3 glomerulopathy: what's in a name? [PDF]
, 2012 Whereas early classifications of membranoproliferative glomerulonephritis (MPGN) were based on morphologic features, the modern approach is directed at immunofluorescence findings. Glomerular deposits of C3 alone, without immunoglobulin, are the hallmark
D'Agati, Vivette D., Bomback, Andrew S.
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