Results 61 to 70 of about 217,483 (203)

C3 glomerulonephritis and thrombotic microangiopathy of renal allograft after pulmonary infection in a male with concomitant two complement factor I gene variations: a case report

BMC Nephrology, 2018
BackgroundIt has been suggested that C3 glomerulonephritis (C3GN) and atypical hemolytic-uremic syndrome (a stereotypical phenotype of thrombotic microangiopathy), two rare entities caused by complement alternative pathway dysregulation share overlapping
J. Wen, Wei Wang, Feng Xu, Jun Sun, Jinsong Chen, X. Ni   +5 more
semanticscholar   +1 more source

Pathology of C3 Glomerulonephritis

Journal of the Korean Society of Pediatric Nephrology, 2013
사구체에 면역글로불린은 음성이면서 C3 만 침착되는 경우, 다른 원인이 없는 경우 C3GN을 의심하여야 한다. 광학현미경으로는 세포의 증식이 있는 경우와 없는 경우가 있지만, 전자현미경으로는 EDD가 내피세포 밑으로 혹은 메산지움 등에 침착함을 확인하여야 한다. 대체보체경로의 조절이상이 원인임으로 혈청 C3 치를 비롯하여 CFH, CFI, CFB 등을 측정하여야 하며, C3 nephritic factor, anti-factor H 자가항체 등을 조사하는 것이 필요하다. 보체 조절이상을 일으키는 유전자 돌연변이를 조사해 보아야 한다. 예후는 안정적이지만, 치료는 대증적이다.
openaire   +1 more source

Durable remission of C3 glomerulonephritis with mycophenolate mofetil [PDF]

Nephrology, 2017
AbstractIn C3 glomerulopathy, uncontrolled complement C3 activation via the alternative pathway results in glomerular C3 deposition and, in many cases, progressive renal failure. Despite advances in understanding of C3G pathogenesis over the last few years, there are no proven treatments.
Nicole, Lioufas, Moira, Finlay, Thomas, Barbour   +2 more
openaire   +2 more sources

C3 glomerulonephritis in Cape Town, South Africa - a case series

, 2023
Background  C3 glomerulonephritis (C3GN) is a rare disease of the alternative complement pathway and is associated with poor kidney and patient outcomes. There are no studies from sub-Saharan Africa.
Chothia, Mogamat-Yazied, Hargey, Irfaan, Coetzee, Liezel, Bates, William   +3 more
core   +1 more source

Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice

Frontiers in Immunology, 2021
Recombinant human factor H (hFH) has potential for treating diseases linked to aberrant complement regulation including C3 glomerulopathy (C3G) and dry age-related macular degeneration.
Heather Kerr, Heather Kerr, Andrew P. Herbert, Elisavet Makou, Dariusz Abramczyk, Talat H. Malik, Hannah Lomax-Browne, Yi Yang, Yi Yang, Isabel Y. Pappworth, Isabel Y. Pappworth, Harriet Denton, Harriet Denton, Anna Richards, Kevin J. Marchbank, Kevin J. Marchbank, Matthew C. Pickering, Paul N. Barlow, Paul N. Barlow   +18 more
doaj   +1 more source

Plasma C3 and C4 Concentrations in Management of Glomerulonephritis [PDF]

BMJ, 1973
As part of a larger study of serial complement profiles in glomerulonephritis plasma C3 and C4 concentrations were measured using commercially available immunodiffusion plates. A total of 303 samples were obtained from 128 patients suffering from forms of nephritis associated with hypocomplementaemia—namely, lupus nephritis, mesangiocapillary ...
J S, Cameron, R M, Vick, C S, Ogg, W M, Seymour, C, Chantler, D R, Turner   +5 more
openaire   +2 more sources

Etiopathogenetic, Morphological, Diagnostic and Therapeutic Aspects of Acute Glomerulonephritis: Current Status

Архивъ внутренней медицины, 2020
The review provides up-to-date information on the etiological factors and pathogenic mechanisms of development, morphological changes, clinical and laboratory manifestations of acute glomerulonephritis, as well as therapeutic possibilities for its ...
I. T. Murkamilov, I. S. Sabirov, V. V. Fomin, Zh. A. Murkamilova, K. A. Aytbaev   +4 more
doaj   +1 more source

Clinicopathological and prognostic study of IgA-dominant postinfectious glomerulonephritis

BMC Nephrology, 2021
Background The clinicopathological and prognostic features of IgA-dominant postinfectious glomerulonephritis and its difference from the primary IgA nephropathy remains to be investigated.
Ziyuan Huang, Bo Chen, Ying Zhou, Yan Liang, Wenxian Qiu, Yinqiu Lv, Xiaokai Ding, Ji Zhang, Chaosheng Chen   +8 more
doaj   +1 more source

A case of recurrent proliferative glomerulonephritis with monoclonal IgG deposits or de novo C3 glomerulonephritis after kidney transplantation

Nephrology, 2018
Proliferative glomerulonephritis with monoclonal immunoglobulin (Ig)G deposits (PGNMID) is a rare disease with a treatment that is not well established.
T. Tamura, K. Unagami, M. Okumi, Y. Kakuta, S. Horita, H. Ishida, J. Koike, K. Honda, K. Tanabe, K. Nitta   +9 more
semanticscholar   +1 more source

C3 glomerulonephritis in multiple myeloma: A case report and literature review. [PDF]

Medicine (Baltimore), 2016
C3 glomerulonephritis (C3 GN) is a recently defined entity characterized by predominant C3 deposition in glomeruli due to abnormal activation of the alternative pathway of complement system. C3 GN has been reported to be associated with several systemic diseases.
Yin G, Cheng Z, Zeng CH, Liu ZH.
europepmc   +3 more sources