Results 81 to 90 of about 18,807 (198)

An inherited defect in the C3 convertase, C3b,Bb, associated with glomerulonephritis [PDF]

, 1983
An inherited defect in the C3 convertase, C3b,Bb, associated with glomerulonephritis. The control of the amplification C3 convertase, C3b,Bb, of the serum complement system has been found to be defective in five members of a family spanning three ...
Beischel, Linda, West, Clark D., Coleman, Thomas H., Marder, Harold K., Forristal, Judith   +4 more
core   +1 more source

A case of glomerulonephritis with dominant C3 with organized deposits complicated by non-tuberculous mycobacteria

Human Pathology Reports
We report a case of membranoproliferative glomerulonephritis (MPGN) with dominant C3 and uniquely organized deposits complicated by pulmonary non-tuberculous mycobacterial (NTM) infection.
Masanori Sudo, Chihiro Sakurazawa, Yuichi Sakamaki, Masato Habuka, Asa Ogawa, Yumi Ito, Naofumi Imai, Sayuri Takamura, Satoshi Ito, Akira Shimizu, Shin Goto, Suguru Yamamoto   +11 more
doaj   +1 more source

C4 nephritic factor in patients with immune-complex-mediated membranoproliferative glomerulonephritis and C3-glomerulopathy

Orphanet Journal of Rare Diseases, 2019
Background Acquired or genetic abnormalities of the complement alternative pathway are the primary cause of C3glomerulopathy(C3G) but may occur in immune-complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) as well. Less is known about the
Nóra Garam, Zoltán Prohászka, Ágnes Szilágyi, Christof Aigner, Alice Schmidt, Martina Gaggl, Gere Sunder-Plassmann, Dóra Bajcsi, Jürgen Brunner, Alexandra Dumfarth, Daniel Cejka, Stefan Flaschberger, Hana Flögelova, Ágnes Haris, Ágnes Hartmann, Andreas Heilos, Thomas Mueller, Krisztina Rusai, Klaus Arbeiter, Johannes Hofer, Dániel Jakab, Mária Sinkó, Erika Szigeti, Csaba Bereczki, Viktor Janko, Kata Kelen, György S. Reusz, Attila J. Szabó, Nóra Klenk, Krisztina Kóbor, Nika Kojc, Maarten Knechtelsdorfer, Mario Laganovic, Adrian Catalin Lungu, Anamarija Meglic, Rina Rus, Tanja Kersnik-Levart, Ernesta Macioniene, Marius Miglinas, Anna Pawłowska, Tomasz Stompór, Ludmila Podracka, Michael Rudnicki, Gert Mayer, Romana Rysava, Jana Reiterova, Marijan Saraga, Tomáš Seeman, Jakub Zieg, Eva Sládková, Tamás Szabó, Andrei Capitanescu, Simona Stancu, Miroslav Tisljar, Kresimir Galesic, András Tislér, Inga Vainumäe, Martin Windpessl, Tomas Zaoral, Galia Zlatanova, Dorottya Csuka   +60 more
doaj   +1 more source

Voclosporin‐induced gingival enlargement: A case report

Clinical Advances in Periodontics, Volume 16, Issue 2, Page 338-343, June 2026.
Abstract Background Drug‐influenced gingival enlargement (DIGE) is a recognized adverse effect of certain medications, particularly immunosuppressants like cyclosporin and tacrolimus. However, there have been no documented cases of DIGE associated with voclosporin, a newer calcineurin inhibitor used primarily to treat lupus nephritis.
Francesca Racca, Jessica M. Greco, Dimitris N. Tatakis   +2 more
wiley   +1 more source

C3 nephritic factor can be associated with membranous glomerulonephritis. [PDF]

, 2015
International audienceC3 nephritic factor (C3NeF) has been described in association with membranoproliferative glomerulonephritis and is involved in 80 % of cases of dense deposit disease.
Guigonis, Vincent, Bérard, Étienne, Thouret, Marie-Christine, Niel, Olivier, Cassuto, Élisabeth, Frémeaux-Bacchi, Véronique, Dallocchio, Aymeric   +6 more
core  

A Rare Presentation of Granulomatosis With Polyangiitis: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Granulomatosis with polyangiitis (GPA) is a rare ANCA‐associated necrotizing vasculitis that predominantly affects the respiratory tract and kidneys. Gastrointestinal involvement is uncommon, and pancreatic manifestations are exceedingly rare. Diffuse alveolar hemorrhage (DAH) represents a severe and potentially fatal complication. We report a
Anil Shahi, Ayush Neupane, Bishaka Adhikari   +2 more
wiley   +1 more source

Understanding the complement-mediated glomerular diseases: focus on membranoproliferative glomerulonephritis and C3 glomerulopathies [PDF]

, 2016
An enhanced understanding of the role of complement in the pathogenesis of membranoproliferative glomerulonephritis has led to reclassification of the latter into immunoglobulin-mediated and non-immunoglobulin-mediated disease.
Lionaki, S., Gakiopoulou, H., Boletis, J.N.   +2 more
core  

PPP2R3C serves as a negative regulator associated with reduced T cell hyperactivation and renal protection in lupus

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Downregulation of PPP2R3C in lupus CD4+ T cells unleashes JNK/c‑Jun and PLCγ1 signalling, driving calcium influx and inflammatory cytokine production. Reconstitution of PPP2R3C expression curbs T cell activation, lowers autoantibody levels and alleviates lupus nephritis, highlighting PPP2R3C as a promising therapeutic candidate. Abstract Background CD4+
Xuan Fang, Yi Qin, Jinhui Tao, Zhou Zhou, Minglong Cai, Hong Zhang, Xiangpei Li, Xiaomei Li, Zhu Chen   +8 more
wiley   +1 more source

Shifting From Systemic to Precision‐Targeted Complement Therapies: Opportunities and Hurdles

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Complement therapeutics have expanded considerably, but systemic inhibitors remain limited by infection risks, breakthrough events, and loss of physiological functions. Emerging targeted approaches aim for organ‐, tissue‐, or cell‐specific modulation of complement activity, potentially offering greater precision while reducing treatment burden and ...
Marco Mannes, Wioleta M. Zelek, Leendert A. Trouw   +2 more
wiley   +1 more source

Atypical Hemolytic Uremic Syndrome Recurrence after Renal Transplantation: C3-Glomerulonephritis as an Initial Presentation [PDF]

, 2015
Risk for atypical hemolytic uremic syndrome (aHUS) recurrence after renal transplantation is low with an isolated membrane cofactor protein mutation (MCP).
Frémeaux Bacchi, Véronique, Martin, Pierre-Yves, Villard, Jean, Moll, Solange, Bouatou, Yassine, Hadaya, Karine   +5 more
core   +1 more source