C3 glomerulonephritis with genetically confirmed C3 deficiency in a pediatric patient: a case report [PDF]
Complement component 3 glomerulonephritis (C3GN) is a rare kidney disease characterized by complement dysregulation that results in prominent complement component 3 (C3) deposition in the kidneys. The clinical course of C3GN varies from mild hematuria to
Ji Hong Kim +8 more
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C3 glomerulopathy associated with mycoplasma pneumoniae infection and positive IgA staining
Background Patients with C3 glomerulopathy (C3G) often have a history of infection, which implies that infection may lead to abnormal activation of the complement alternative pathway (CAP) and induce the development of C3G.
Zhi-Yu Duan +7 more
doaj +1 more source
Schistosomal nephropathy has long been related to the hepatosplenic form of schistosomiasis. In the last few years, 24 patients with hepatointestinal schistosomiasis and the nephrotic syndrome were studied.
H. Abensur +6 more
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Influenza a H1N1 associated acute glomerulonephritis in an adolescent
Influenza virus primarily affects the respiratory system. It rarely causes extrapulmonary complications, with otitis media and febrile seizures being the most common in children.
Garyfallia Syridou +9 more
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COMPLEMENT-MEDIATED ADIPOCYTE LYSIS BY NEPHRITIC FACTOR SERA [PDF]
Recent data indicate a previously unsuspected link between the complement system and adipocyte biology. Murine adipocytes produce key components of the alternative pathway of complement and are able to activate this pathway.
Lachmann, PJ +10 more
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In this study, we evaluated the utility of polyclonal rabbit anti-human IgA, IgG, IgM, Kappa, Lambda - FITC antibody cocktail (CTA) in identifying immune complex deposits in conjunction with C3 & C1q antibodies in consecutive transplant renal biopsies. A
Shilpi Thakur +2 more
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Successful simultaneous liver-kidney transplantation for renal failure associated with hereditary complement C3 deficiency. [PDF]
Hereditary complement C3 deficiency is associated with recurrent bacterial infections and proliferative glomerulonephritis. We describe a case of an adult with complete deficiency of complement C3 due to homozygous mutations in C3 gene: c.1811delT ...
Delaney, Michael +19 more
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Glomerulonephritis with isolated C3 deposits and monoclonal gammopathy: a fortuitous association? [PDF]
International audienceBACKGROUND AND OBJECTIVES: Glomerular deposition of monoclonal Ig has been exceptionally described as the cause of membranoproliferative glomerulonephritis, through activation of the complement alternative pathway (CAP).
Christine Fen Chong +15 more
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Primary immune complex membranoproliferative glomerulonephritis and C3 glomerulonephritis: experience of two rare diseases from a single centre [PDF]
Background: This study has been conducted to evaluate and compare the clinicopathological profile and treatment outcome of primary immune complex membranoproliferative glomerulonephritis (IC-MPGN) and C3 glomerulonephritis (C3 GN), two rare glomerular ...
Barai, Tonmay +3 more
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Pathogenesis and approaches to therapy of membranoproliferative glomerulonephritis [PDF]
In 1965, it was observed that patients with glomerulonephritis with persistently low serum concentrations of C3 evolved to have similar glomerular morphologic characteristics, particularly recognizable in biopsy specimens stained by the Jones methenamine
West, Clark D., Clark D. West
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