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Recurrence of rare disease after kidney transplant [PDF]
Journal of Nephropharmacology, 2023 The incidence of chronic kidney diseases (CKDs) by rare etiologies is growing along with other CKDs. This mini-review discusses the epidemiology, pathogenesis, clinical presentation, and diagnosis of rare kidney disease recurrence after kidney ...
Farahnoosh Farnood +4 more
doaj +1 more source
Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice [PDF]
, 2019 Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-function mutations in complement-regulating proteins or gain-of-function mutations in complement-activating proteins.
Atkinson, John P +11 more
core +3 more sources
Characterization of C3 in C3 glomerulopathy [PDF]
Nephrology Dialysis Transplantation, 2016 Abstract Background: C3 glomerulopathy (C3G) is caused by overactivity of the alternative pathway of complement that results in bright glomerular C3 staining with minimal or no deposition of immunoglobulins on immunofluorescence microscopy.
Sanjeev, Sethi +7 more
openaire +2 more sources
An Interdisciplinary Diagnostic Approach to Guide Therapy in C3 Glomerulopathy
Frontiers in Immunology, 2022 Since the re-classification of membranoproliferative glomerulonephritis the new disease entity C3 glomerulopathy is diagnosed if C3 deposition is clearly dominant over immunoglobulins in immunohistochemistry or immunofluorescence.
Tilman Schmidt +9 more
doaj +1 more source
Update on C3 glomerulopathy [PDF]
Nephrology Dialysis Transplantation, 2014 C3 glomerulopathy refers to a disease process in which abnormal control of complement activation, degradation or deposition results in predominant C3 fragment deposition within the glomerulus and glomerular damage. Recent studies have improved our understanding of its pathogenesis.
Barbour, TD, Ruseva, MM, Pickering, MC
openaire +4 more sources
Case Reports in Nephrology and Dialysis, 2018 The advances in our understanding of the alternative pathway have emphasized that uncontrolled hyperactivity of this pathway causes 2 distinct disorders that adversely impact the kidney.
Ravneet Bajwa +10 more
doaj +1 more source
Monoclonal gammopathy of renal significance: Diagnostic workup [PDF]
, 2017 The clinical spectrum of diseases associated with monoclonal gammopathies is wide and they are most commonly the consequence of renal deposition of monoclonal immunoglobulin or its components.
Cabrita, A. +5 more
core +1 more source
Nefrología (English Edition), 2019 Monoclonal gammopathy of renal significance includes all renal disorders caused by a monoclonal immunoglobulin secreted by a non-malignant B-cell clone.
Núria Serra +11 more
doaj +1 more source
A new complement factor B mutation associated with crescentic C3 glomerulopathy; a case report [PDF]
Journal of Nephropathology, 2019 Background: C3 glomerulopathy is a recently described entity classified as complementassociated glomerular disease. Case Presentation: We report a case of a 48-year-old man referred to the nephrology department for nephrotic syndrome with rapidly ...
Sofia Semedo Coelho +10 more
doaj +1 more source
Frontiers in Immunology, 2021 The impairment of the alternative complement pathway contributes to rare kidney diseases such as atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G).
Aleksandra Urban +15 more
doaj +1 more source