Results 31 to 40 of about 162,041 (218)

C3 Glomerulopathy Diagnosis, Current Treatments, and Emerging Therapies [PDF]

Kidney Medicine
C3 glomerulopathy (C3G) is characterized by prominent deposition of complement component C3 in the kidney glomeruli, leading to glomerular inflammation.
Mahtab Mashayekhi, Jonathan E. Zuckerman, Jonathan Barratt, Richard J. Glassock, Fernando Caravaca-Fontán, Raymond K. Hsu, Arun Rajasekaran, Edgar Lerma, Sahibzadi Mahrukh Noor, Amir Abdipour, Sayna Norouzi   +10 more
doaj   +2 more sources

Three cases of monoclonal gammopathy of renal significance after kidney transplantation. De novo C3 glomerulopathy

Nefrología (English Edition), 2019
Monoclonal gammopathy of renal significance includes all renal disorders caused by a monoclonal immunoglobulin secreted by a non-malignant B-cell clone.
Núria Serra, Carme Facundo, Cristina Canal, Yolanda Arce, Nadia Ayasreh, Anna Vila, Beatriz Bardají, Irene Silva, Víctor López, Silvia Benito, Jose Ballarín, Lluís Guirado   +11 more
doaj   +2 more sources

Comparative Analysis of Proteinuria and Longitudinal Outcomes in Immune Complex Membranoproliferative Glomerulonephritis and C3 Glomerulopathy. [PDF]

Kidney Int Rep
Introduction C3 glomerulopathy (C3G) and primary immune complex–mediated membranoproliferative glomerulonephritis (IC-MPGN) are rare diseases that share a similar pathogenesis; however, the prognostic significance of proteinuria reduction remains poorly ...
Caravaca-Fontán F, Toledo-Rojas R, Huerta A, Pérez-Canga JL, Martínez-Miguel P, Miquel R, Da Silva I, Verdalles Ú, Albornoz M, Durán López CM, Mon C, Fernández-Juárez G, Praga M, C3G study group from the Spanish Group for the Study of Glomerular Diseases.   +13 more
europepmc   +2 more sources

Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy. [PDF]

Front Immunol
Introduction Dysregulation of the alternative pathway of complement underlies the pathogenesis of C3 glomerulopathy (C3G). Because Factor H (FH) prevents excessive alternative pathway activity while Factor H-related protein 1 (FHR-1) is believed to ...
Slagle AK, Ghiringhelli Borsa N, Wang K, Taylor AO, Meyer NC, Jones MB, Walls WD, Nelson AFM, Roberts SM, Sun M, Goicoechea de Jorge E, Rodriguez de Cordoba S, Jalal DI, Nester CM, Zhang Y, Smith RJH.   +15 more
europepmc   +2 more sources

Kidney Transplantation in Children and Adolescents With C3 Glomerulopathy or Immune Complex Membranoproliferative Glomerulonephritis: An International Survey of Current Practice. [PDF]

Pediatr Transplant
Approximately 50% of patients with chronic kidney disease due to C3 glomerulopathy (C3G) or primary immune‐complex membranoproliferative glomerulonephritis (IC‐MPGN) will require dialysis and/or kidney transplantation (KTx) within the first 10 years of ...
Patry C, Webb NJA, Meier M, Pape L, Fichtner A, Höcker B, Tönshoff B.   +6 more
europepmc   +2 more sources

C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases [PDF]

Frontiers in Immunology, 2019
C3 glomerulopathy (C3G) is a severe kidney disease, which is caused by defective regulation of the alternative complement pathway. Disease pathogenesis is heterogeneous and is caused by both autoimmune and genetic factors.
Fei Zhao, Sara Afonso, Susanne Lindner, Andrea Hartmann, Ina Löschmann, Bo Nilsson, Kristina N. Ekdahl, Lutz T. Weber, Sandra Habbig, Gesa Schalk, Michael Kirschfink, Peter F. Zipfel, Peter F. Zipfel, Christine Skerka   +13 more
doaj   +2 more sources

C3 glomerulopathy: a new classification

Nature Reviews Nephrology, 2010
Several distinct pathological patterns of glomerular inflammation are associated with abnormal regulation of the complement system, specifically, with dysregulation of the alternative pathway of the complement system.
Laure-Hélène Noël, H. Terence Cook, Fremeaux-Bacchi, V., Pickering, M. C., Matthew C. Pickering, Fakhouri, F., Fadi Fakhouri, Véronique Frémeaux-Bacchi, Noel, L. H., Cook, H. T.   +9 more
core   +3 more sources

Patterns of Clinical Response to Eculizumab in Patients With C3 Glomerulopathy

American Journal of Kidney Diseases, 2018
International audienceBackground: Cases reports and small series of patients with C3 glomerulopathy have reported variable efficacy of eculizumab.Study design: Case series of C3 glomerulopathy.Setting & participants: Pediatric and adult patients with C3 ...
Moglie Le Quintrec, Anne-Laure Sellier-Leclerc, Eric Daugas   +2 more
exaly   +2 more sources

Clinical Presentation, Treatment Patterns, Burden of Disease, and the Association of Proteinuria with Clinical Outcomes in C3 Glomerulopathy and Primary Immune Complex Membranoproliferative Glomerulonephritis: A Systematic Review.

Nephron
Introduction: Knowledge gaps and controversies remain regarding the natural history and variability of C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN).
Caravaca-Fontán F, Fakhouri F, Pickering MC, Lionikaite V, Baird A, Horneff R, López-Lázaro L, Quintana-Gallardo L, Rich C.   +8 more
europepmc   +2 more sources

C3 glomerulopathy: a kidney disease mediated by alternative pathway deregulation. [PDF]

Front Nephrol
C3 glomerulopathy (C3G) is an ultra-rare complement-mediated kidney disease caused by to the deregulation of the alternative pathway (AP) of proximal complement.
Heidenreich K, Goel D, Priyamvada PS, Kulkarni S, Chakurkar V, Khullar D, Singh R, Bale C, Zipfel PF.   +8 more
europepmc   +2 more sources