Results 31 to 40 of about 216,693 (188)

Pegcetacoplan in idiopathic and familial pediatric C3 glomerulopathy. [PDF]

Pediatr Nephrol
C3 glomerulopathy (C3G) and immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) represent a continuous spectrum of a glomerular disease driven by dysregulation of the complement and characterized by C3 deposition alone or ...
Román Ortiz E, Sáez Bello M, Reparaz Suevos A, Perez Ebri M, Aguilar Bacallado F, LLopis Salvia P, Climente Martí M, Rodriguez de Córdoba S.   +7 more
europepmc   +2 more sources

Three cases of monoclonal gammopathy of renal significance after kidney transplantation. De novo C3 glomerulopathy

Nefrología (English Edition), 2019
Monoclonal gammopathy of renal significance includes all renal disorders caused by a monoclonal immunoglobulin secreted by a non-malignant B-cell clone.
Núria Serra, Carme Facundo, Cristina Canal, Yolanda Arce, Nadia Ayasreh, Anna Vila, Beatriz Bardají, Irene Silva, Víctor López, Silvia Benito, Jose Ballarín, Lluís Guirado   +11 more
doaj   +1 more source

A new complement factor B mutation associated with crescentic C3 glomerulopathy; a case report [PDF]

Journal of Nephropathology, 2019
Background: C3 glomerulopathy is a recently described entity classified as complementassociated glomerular disease. Case Presentation: We report a case of a 48-year-old man referred to the nephrology department for nephrotic syndrome with rapidly ...
Sofia Semedo Coelho, Ana Raquel Fernandes, Elsa Soares, Patrícia Valério, Bruno Matos, Helena Romão, Mário Góis, Helena Sousa, Teresa Fidalgo, Ana Sofia Natário, Carlos Barreto   +10 more
doaj   +1 more source

Gain-of-Function Mutations R249C and S250C in Complement C2 Protein Increase C3 Deposition in the Presence of C-Reactive Protein

Frontiers in Immunology, 2021
The impairment of the alternative complement pathway contributes to rare kidney diseases such as atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G).
Aleksandra Urban, Daria Kowalska, Grzegorz Stasiłojć, Alicja Kuźniewska, Anna Skrobińska, Emilia Arjona, Eugenia Castellote Alonso, María Ángeles Fenollosa Segarra, Ilse Jongerius, Ilse Jongerius, Robbert Spaapen, Simon Satchell, Marcel Thiel, Stanisław Ołdziej, Santiago Rodriguez de Córdoba, Marcin Okrój   +15 more
doaj   +1 more source

C4d at Crossroads Between Post-Infectious Glomerulonephritis and C3 Glomerulopathy

International Journal of Nephrology and Renovascular Disease, 2021
Shaarif Bashir,1 Mudassar Hussain,1 Aurangzeb Afzal,2 Usman Hassan,1 Maryam Hameed,1 Sajid Mushtaq1 1Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, 54000, Pakistan; 2Department of Nephrology, Lahore General ...
Bashir S, Hussain M, Afzal A, Hassan U, Hameed M, Mushtaq S   +5 more
doaj  

Tres casos de gammapatía monoclonal de significado renal postrasplante renal: nefropatía c3 de novo

Nefrología, 2019
Resumen: La gammapatía monoclonal de significado renal incluye todas las enfermedades renales causadas por una inmunoglobulina monoclonal secretada por un clon de célula B no maligno. Por definición, los pacientes con gammapatía monoclonal de significado
Núria Serra, Carme Facundo, Cristina Canal, Yolanda Arce, Nadia Ayasreh, Anna Vila, Beatriz Bardají, Irene Silva, Víctor López, Silvia Benito, Jose Ballarín, Lluís Guirado   +11 more
doaj   +1 more source

Eculizumab as a treatment for C3 glomerulopathy: a single-center retrospective study

BMC Nephrology, 2023
Background C3 Glomerulopathy (C3G) is a rare glomerular disease caused by dysregulation of the complement pathway. Based on its pathophysiology, treatment with the monoclonal antibody eculizumab targeting complement C5 may be a therapeutic option. Due to
Thomas Welte, Frederic Arnold, Lukas Westermann, Felix A. Rottmann, Martin J. Hug, Elke Neumann-Haefelin, Athina Ganner   +6 more
doaj   +1 more source

C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: a diagnostic and therapeutic challenge [PDF]

Brazilian Journal of Nephrology
C3 glomerulopathy represents a heterogeneous group of glomerulopathies characterized by hyperactivity of the alternative complement pathway. Although the pathophysiology is incompletely understood, an association between this disease and monoclonal ...
Bárbara Beirão, Mariana Freitas, Natália Silva, Patrícia Ferraz, Catarina Prata, Teresa Morgado   +5 more
doaj   +1 more source

C3 Glomerulopathy [PDF]

Clinical Journal of the American Society of Nephrology, 2014
Summary Background and objectives The term C3 glomerulopathy describes renal disorders characterized by the presence of glomerular deposits composed of C3 in the absence of significant amounts of Ig. On the basis of electron microscopy appearance, subsets of C3 glomerulopathy include dense deposit disease (DDD) and C3
Nicholas R, Medjeral-Thomas, Michelle M, O'Shaughnessy, John A, O'Regan, Carol, Traynor, Michael, Flanagan, Limy, Wong, Chia Wei, Teoh, Atif, Awan, Mary, Waldron, Tom, Cairns, Patrick, O'Kelly, Anthony M, Dorman, Matthew C, Pickering, Peter J, Conlon, H Terence, Cook   +14 more
openaire   +2 more sources

Diverse Clinical Presentations of C3 Dominant Glomerulonephritis

Frontiers in Medicine, 2020
C3 dominant immunofluorescence staining is present in a subset of patients with idiopathic immune complex membranoproliferative glomerulonephritis (iMPGN).
Ramy M. Hanna, Ramy M. Hanna, Jean Hou, Huma Hasnain, Farid Arman, Umut Selamet, Umut Selamet, James Wilson, Samuel Olanrewaju, Jonathan E. Zuckerman, Marina Barsoum, Julie M. Yabu, Ira Kurtz, Ira Kurtz   +13 more
doaj   +1 more source