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C3 glomerulopathy [version 1; referees: 4 approved] [PDF]
F1000Research, 2017 C3 glomerulopathy is a recently defined entity that encompasses a group of kidney diseases caused by abnormal control of complement activation with deposition of complement component C3 in glomeruli leading to variable glomerular inflammation. Before the
H. Terence Cook
doaj +6 more sources
C3 glomerulopathy: consensus report. [PDF]
Kidney International, 2013 C3 glomerulopathy is a recently introduced pathological entity whose original definition was glomerular pathology characterized by C3 accumulation with absent or scanty immunoglobulin deposition.
LAVIN, PETER
core +11 more sources
Update on C3 glomerulopathy [PDF]
Nephrology Dialysis Transplantation, 2014 C3 glomerulopathy refers to a disease process in which abnormal control of complement activation, degradation or deposition results in predominant C3 fragment deposition within the glomerulus and glomerular damage.
Ruseva, MM, Pickering, MC, Barbour, TD
core +5 more sources
Recent insights into C3 glomerulopathy [PDF]
Nephrology Dialysis Transplantation, 2012 ‘C3 glomerulopathy’ is a recent disease classification comprising several rare types of glomerulonephritis (GN), including dense deposit disease (DDD), C3 glomerulonephritis (C3GN) and CFHR5 nephropathy. These disorders share the key histological feature
Pickering, MC, Cook, HT, Barbour, TD
core +5 more sources
Treating C3 glomerulopathy with eculizumab [PDF]
BMC Nephrology, 2018 Background C3 glomerulopathy (C3G) is a rare, but severe glomerular disease with grim prognosis. The complex pathogenesis is just unfolding, and involves acquired as well as inherited dysregulation of the alternative pathway of the complement cascade ...
Thomas Welte +7 more
doaj +4 more sources
Glomerular C4d Staining Does Not Exclude a C3 Glomerulopathy
Kidney International Reports, 2019 Introduction: C4d, an early product in the classical/lectin complement pathway has shown potential in the evaluation of C3 glomerulopathy where its absence would support an alternative pathway abnormality.
Geetika Singh +11 more
doaj +2 more sources
C3 glomerulopathy in cystic fibrosis: a case report
BMC Nephrology, 2018 Background C3 glomerulonephritis is a rare glomerulopathy characterized at renal biopsy by C3 deposition, alone or with scanty immunoglobulins, as well as by an electron-dense material in mesangium, subendothelial and subepithelial space.
Domenico Santoro +9 more
doaj +2 more sources
An Interdisciplinary Diagnostic Approach to Guide Therapy in C3 Glomerulopathy [PDF]
Frontiers in Immunology, 2022 Since the re-classification of membranoproliferative glomerulonephritis the new disease entity C3 glomerulopathy is diagnosed if C3 deposition is clearly dominant over immunoglobulins in immunohistochemistry or immunofluorescence.
Tilman Schmidt +9 more
doaj +2 more sources
Evaluation of the children with C3 glomerulopathy
Saudi Journal of Kidney Diseases and Transplantation, 2020 C3 glomerulopathy (C3G) is a clinical spectrum that presents with a variety of symptoms, ranging from a mild disease with asymptomatic microhematuria and/or proteinuria to severe disease with nephritic or nephrotic syndrome and renal impairment.
Ayse Seda Pinarbasi +5 more
doaj +4 more sources
C3 glomerulopathy: a new classification
Nature Reviews Nephrology, 2010 Several distinct pathological patterns of glomerular inflammation are associated with abnormal regulation of the complement system, specifically, with dysregulation of the alternative pathway of the complement system.
Laure-Hélène Noël +9 more
core +3 more sources