Results 11 to 20 of about 6,839 (215)

C3 glomerulopathy [version 1; referees: 4 approved] [PDF]

F1000Research, 2017
C3 glomerulopathy is a recently defined entity that encompasses a group of kidney diseases caused by abnormal control of complement activation with deposition of complement component C3 in glomeruli leading to variable glomerular inflammation. Before the
H. Terence Cook
doaj   +5 more sources

Diagnostic Problems in C3 Glomerulopathy

Biomedicines, 2023
Background: C3 glomerulopathies (C3GN) are a group of rare kidney diseases associated with impaired complement regulation. The effects of this disease include the accumulation of complement C3 in the kidneys. Based on the clinical data, as well as light,
Leszek Niepolski, Anna Czekała, Monika Seget-Dubaniewicz, Magdalena Frydrychowicz, Patrycja Talarska-Markiewicz, Angelika Kowalska, Jagoda Szmelter, Wiesława Salwa-Żurawska, Tomasz Sirek, Dawid Sobański, Beniamin Oskar Grabarek, Jakub Żurawski   +11 more
doaj   +3 more sources

Treating C3 glomerulopathy with eculizumab [PDF]

BMC Nephrology, 2018
Background C3 glomerulopathy (C3G) is a rare, but severe glomerular disease with grim prognosis. The complex pathogenesis is just unfolding, and involves acquired as well as inherited dysregulation of the alternative pathway of the complement cascade ...
Thomas Welte, Frederic Arnold, Julia Kappes, Maximilian Seidl, Karsten Häffner, Carsten Bergmann, Gerd Walz, Elke Neumann-Haefelin   +7 more
doaj   +4 more sources

Remissions and progression of C3 glomerulopathy

Терапевтический архив, 2022
Aim. To analyze the outcomes of C3-glomerulopathy (C3-GP) and determine the associated factors. Materials and methods. A retrospective single-center study included 60 patients with newly diagnosed C3-GP (with primary C3-GP pC3-GP 82%). Of these, 48 (
Anna V. Karunnaya, Vladimir A. Dobronravov   +1 more
doaj   +3 more sources

Overview of C3 Glomerulopathy [PDF]

Frontiers in Pediatrics, 2016
C3 glomerulopathy is an umbrella term, which includes several rare forms of glomerulonephritis (GN) with underlying defects in the alternate complement cascade. A common histological feature noted in all these GN is dominant C3 deposition in the glomerulus.
Deepa H. Chand, Roberto Gordillo, Vimal Master Sankar Raj   +2 more
core   +4 more sources

C3 glomerulopathy: consensus report [PDF]

Kidney International, 2013
C3 glomerulopathy is a recently introduced pathological entity whose original definition was glomerular pathology characterized by C3 accumulation with absent or scanty immunoglobulin deposition.
Alpers, Charles E, Appel, Gerald B, Bajema, Ingeborg M, Bedrosian, Camille, Braun, Michael, Cook, H Terence, D'Agati, Vivette D, de Jorge, Elena Goicoechea, Doyle, Mittie, Fakhouri, Fadi, Fervenza, Fernando C, Fogo, Agnes B, Fremeaux-Bacchi, Veronique, Gale, Daniel P, Griffin, Gene, Haas, Mark, Harris, Claire L, Holers, V Michael, Johnson, Sally, Lavin, Peter J, Medjeral-Thomas, Nicholas, Morgan, B Paul, Nast, Cynthia C, Nester, Carla M, Noel, Laure-Helene, Peters, D Keith, Pickering, Matthew C, Rodriguez de Cordoba, Santiago, Servais, Aude, Sethi, Sanjeev, Smith, Richard J, Song, Wen-Chao, Tamburini, Paul, Thurman, Joshua M, Zavros, Michael   +34 more
core   +9 more sources

C3 glomerulopathy

Cleveland Clinic Journal of Medicine, 2023
C3 glomerulopathy (C3G) is a rare kidney disease that causes kidney dysfunction as a result of dysregulation of the complement system alternate pathway (AP). C3G encompasses 2 separate disorders, C3 glomerulonephritis and dense deposit disease. The presentation and natural history is variable and kidney biopsy is needed to confirm the diagnosis.
Ali, Mehdi, Jonathan J, Taliercio
openaire   +2 more sources

C3 glomerulopathy associated with both hypertensive retinopathy and purtscher-like retinopathy

American Journal of Ophthalmology Case Reports, 2022
Purpose: This article reports the case of a 21-year-old woman with both hypertensive retinopathy and Purtscher-like retinopathy in association with C3 glomerulopathy.
Moosa Zaidi, Kapil Mishra, Huy Vu Nguyen, Paul Peter Miller, Hashem Ghoraba, Irmak Karaca, Wataru Matsumiya, Quan Dong Nguyen, Loh-Shan Bryan Leung   +8 more
doaj   +1 more source

Acquired drivers of C3 glomerulopathy. [PDF]

Clin Kidney J
Abstract C3 glomerulopathy (C3G) is a group of heterogeneous ultrarare kidney diseases characterized by dysregulated activation of the complement alternative pathway (AP) leading to excessive C3 cleavage. Diagnosis relies on kidney biopsy showing predominant C3 deposition in the glomerular basement membrane, with electron microscopy ...
Welsh SJ, Zhang Y, Smith RJH.
europepmc   +3 more sources

Favorable effect of bortezomib in dense deposit disease associated with monoclonal gammopathy: a case report

BMC Nephrology, 2018
Background Complement component 3 (C3) glomerulopathy, which includes dense deposit disease (DDD) and C3 glomerulonephritis, is caused by dysregulation of the alternative complement pathway.
Shuma Hirashio, Ayaka Satoh, Takahiro Arima, Kouichi Mandai, Tadasuke Awaya, Kumi Oshima, Shigeo Hara, Takao Masaki   +7 more
doaj   +1 more source