Results 41 to 50 of about 216,693 (188)

Glomerular C3 Deposition Is an Independent Risk Factor for Allograft Failure in Kidney Transplant Recipients With Transplant Glomerulopathy

Kidney International Reports, 2019
Introduction: Transplant glomerulopathy (TG) becomes increasingly prevalent in kidney transplant recipients over time, and it is strongly associated with allograft failure.
Sarah E. Panzer, Emily Joachim, Sandesh Parajuli, Weixiong Zhong, Brad C. Astor, Arjang Djamali   +5 more
doaj   +1 more source

Acquired drivers of C3 glomerulopathy. [PDF]

Clin Kidney J
Abstract C3 glomerulopathy (C3G) is a group of heterogeneous ultrarare kidney diseases characterized by dysregulated activation of the complement alternative pathway (AP) leading to excessive C3 cleavage. Diagnosis relies on kidney biopsy showing predominant C3 deposition in the glomerular basement membrane, with electron microscopy ...
Welsh SJ, Zhang Y, Smith RJH.
europepmc   +3 more sources

C3 Glomerulopathy

, 2018
<p>C3 glomerulopathy (C3G) encompasses a group of severe renal diseases characterized by “dominant C3” deposition in the renal glomerulus. Patients typically present as nephritic nephrotics, with hematuria, hypertension, heavy proteinuria and edema.
Xue Xiao, Carla M. Nester, Val C. Sheffield, Robert F. Mullins, Paul B. McCray, Richard J.H. Smith   +5 more
openaire   +3 more sources

C3 glomerulopathy and current dilemmas [PDF]

Clinical and Experimental Nephrology, 2016
C3 glomerulopathy (C3G) is a recently identified disease entity caused by dysregulation of the alternative complement pathway, and dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are its components. Because laboratory detection of complement dysregulation is still uncommon in practice, "dominant C3 deposition by two orders greater than ...
Naoko Ito, Ryuji Ohashi, Michio Nagata
openaire   +2 more sources

C3 glomerulopathy: what's in a name? [PDF]

, 2012
Whereas early classifications of membranoproliferative glomerulonephritis (MPGN) were based on morphologic features, the modern approach is directed at immunofluorescence findings. Glomerular deposits of C3 alone, without immunoglobulin, are the hallmark
D'Agati, Vivette D., Bomback, Andrew S.
core   +1 more source

Acquired partial lipodystrophy and C3 glomerulopathy: Dysregulation of the complement system as a common mechanism

Nefrología (English Edition), 2018
The activation of the alternative pathway of the complement is involved in the development of several renal diseases, such as atypical haemolytic uraemic syndrome and C3 glomerulopathy. In C3 glomerulopathy, a high percentage of patients have circulating
Fernando Corvillo, Margarita López-Trascasa   +1 more
doaj   +1 more source

C3 Glomerulopathy With Concurrent Thrombotic Microangiopathy: Clinical and Immunological Features

, 2023
International audienceKey Points We evidenced terminal pathway activation (C5b-9 deposits) in most of the glomeruli on kidney biopsy of C3 glomerulopathy. The amount of C5b-9 deposits correlated with disease prognosis in C3 glomerulopathy.
Rabant, Marion, Sophie Caillard, Karras, Alexandre, Ferlicot, Sophie, Didier Ducloux, Kandel, Christine, Dragon-Durey, Marie-Agnès, Caillard, Sophie, El Sissy, Carine, Melchior Chabannes, Audard, Vincent, Ducloux, Didier, Daugas, Eric, Alexandre Karras, Bridoux, Frank, Carine El Sissy, Sophie Chauvet, Thervet, Eric, Christine Kandel, Sophie Ferlicot, Paula Vieira Martins, Carole Philipponnet, Philipponnet, Carole, Vincent Audard, Olagne, Jérôme, Chauvet, Sophie, David Buob, Thomas Crepin, Buob, David, Eric Daugas, Crepin, Thomas, Frémeaux-Bacchi, Véronique, Meuleman, Marie Sophie, Marie-Agnès Dragon-Durey, Marie Sophie Meuleman, Véronique Frémeaux-Bacchi, Eric Thervet, Vieira Martins, Paula, Jérôme Olagne, Frank Bridoux, Chabannes, Melchior, Marion Rabant   +41 more
core   +1 more source

Factor B Inhibition with Iptacopan in Recurrent C3 Glomerulopathy Following Kidney Transplant: A Report of Two Cases

Kidney Medicine
C3 glomerulopathy is a rare disease caused by fluid phase dysregulation of the alternative complement pathway. Currently, treatment depends on clinical and histological severity and includes nephroprotection, unspecific immunosuppression, and terminal ...
Víctor J. Escudero-Saiz, Ángela Gonzalez, Adriana García-Herrera, Ana B. Larque, Andrew S. Bomback, Laura Morantes, Marta Martínez-Chillarón, Júlia Ollé, Elena Guillén, Marc Xipell, Alicia Molina-Andújar, Diana Rodríguez, Elena Cuadrado, Judit Cacho, Carolt Arana, Núria Esforzado, Carla Bastida, Esteban Poch, Fritz Diekman, David Cucchiari, Luis F. Quintana, Miquel Blasco   +21 more
doaj   +1 more source

Lipodistrofia parcial adquirida y glomerulopatía C3: la desregulación del sistema del complemento como mecanismo común

Nefrología, 2018
Resumen: La activación de la vía alternativa del complemento interviene en el desarrollo de varias enfermedades renales, como el síndrome hemolítico urémico atípico o la glomerulopatía C3.
Fernando Corvillo, Margarita López-Trascasa   +1 more
doaj   +1 more source

Efficacy of targeted complement inhibition in experimental C3 glomerulopathy [PDF]

, 2015
C3 glomerulopathy refers to renal disorders characterised by abnormal accumulation of C3 within the kidney, commonly along the glomerular basement membrane (GBM).
Lasaro, MA, Sun, F, Wang, Y, Ruseva, MM, Pickering, MC, Liu-Chen, S, Yu, Z-X, Bouchard, K, Peng, T, Marozsan, A   +9 more
core   +1 more source