Results 51 to 60 of about 162,041 (218)

Heterozygous laminin β2 mutation in C3 glomerulopathy

Saudi Journal of Kidney Diseases and Transplantation, 2021
C3 glomerulopathy is usually seen with the presence of C3 nephritic factor, homozygous or heterozygous mutations in the regulatory complement proteins factor H, factor I, or C3. We describe the presence of heterozygous laminin β2 mutation in a patient of
Manish R Balwani, Amit S Pasari, Amol R Bhawane, Priyanka R Tolani   +3 more
doaj   +1 more source

C3 glomerulopathy associated with both hypertensive retinopathy and purtscher-like retinopathy

American Journal of Ophthalmology Case Reports, 2022
Purpose: This article reports the case of a 21-year-old woman with both hypertensive retinopathy and Purtscher-like retinopathy in association with C3 glomerulopathy.
Moosa Zaidi, Kapil Mishra, Huy Vu Nguyen, Paul Peter Miller, Hashem Ghoraba, Irmak Karaca, Wataru Matsumiya, Quan Dong Nguyen, Loh-Shan Bryan Leung   +8 more
doaj   +1 more source

Why Is C5a Inflammatory Complement Inhibition Not Enough to Improve C3 Glomerulopathy? [PDF]

J Am Soc Nephrol
Zipfel PF, Skerka C.
europepmc   +2 more sources

Favorable effect of bortezomib in dense deposit disease associated with monoclonal gammopathy: a case report

BMC Nephrology, 2018
Background Complement component 3 (C3) glomerulopathy, which includes dense deposit disease (DDD) and C3 glomerulonephritis, is caused by dysregulation of the alternative complement pathway.
Shuma Hirashio, Ayaka Satoh, Takahiro Arima, Kouichi Mandai, Tadasuke Awaya, Kumi Oshima, Shigeo Hara, Takao Masaki   +7 more
doaj   +1 more source

Recurrence of rare disease after kidney transplant [PDF]

Journal of Nephropharmacology, 2023
The incidence of chronic kidney diseases (CKDs) by rare etiologies is growing along with other CKDs. This mini-review discusses the epidemiology, pathogenesis, clinical presentation, and diagnosis of rare kidney disease recurrence after kidney ...
Farahnoosh Farnood, Seyyedeh Mina Hejazian, Kamal Boostani, Alireza Mardomi, Mohammadreza Ardalan   +4 more
doaj   +1 more source

A new complement factor B mutation associated with crescentic C3 glomerulopathy; a case report [PDF]

Journal of Nephropathology, 2019
Background: C3 glomerulopathy is a recently described entity classified as complementassociated glomerular disease. Case Presentation: We report a case of a 48-year-old man referred to the nephrology department for nephrotic syndrome with rapidly ...
Sofia Semedo Coelho, Ana Raquel Fernandes, Elsa Soares, Patrícia Valério, Bruno Matos, Helena Romão, Mário Góis, Helena Sousa, Teresa Fidalgo, Ana Sofia Natário, Carlos Barreto   +10 more
doaj   +1 more source

Clinical Safety and Efficacy of Pegcetacoplan in a Phase 2 Study of Patients with C3 Glomerulopathy and Other Complement-Mediated Glomerular Diseases

Kidney International Reports, 2023
Introduction Dysregulated complement activation is likely the primary driver of disease in C3 glomerulopathy (C3G) and contributes to other complement-mediated diseases, including immunoglobulin A nephropathy (IgAN), lupus nephritis (LN), and primary ...
B. Dixon, L. Greenbaum, Liwei Huang, S. Rajan, C. Ke, Yiwei Zhang, Li Li   +6 more
semanticscholar   +1 more source

C4d at Crossroads Between Post-Infectious Glomerulonephritis and C3 Glomerulopathy

International Journal of Nephrology and Renovascular Disease, 2021
Shaarif Bashir,1 Mudassar Hussain,1 Aurangzeb Afzal,2 Usman Hassan,1 Maryam Hameed,1 Sajid Mushtaq1 1Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, 54000, Pakistan; 2Department of Nephrology, Lahore General ...
Bashir S, Hussain M, Afzal A, Hassan U, Hameed M, Mushtaq S   +5 more
doaj  

Gain-of-Function Mutations R249C and S250C in Complement C2 Protein Increase C3 Deposition in the Presence of C-Reactive Protein

Frontiers in Immunology, 2021
The impairment of the alternative complement pathway contributes to rare kidney diseases such as atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G).
Aleksandra Urban, Daria Kowalska, Grzegorz Stasiłojć, Alicja Kuźniewska, Anna Skrobińska, Emilia Arjona, Eugenia Castellote Alonso, María Ángeles Fenollosa Segarra, Ilse Jongerius, Ilse Jongerius, Robbert Spaapen, Simon Satchell, Marcel Thiel, Stanisław Ołdziej, Santiago Rodriguez de Córdoba, Marcin Okrój   +15 more
doaj   +1 more source

C3 Glomerulopathy and Related Disorders in Children: Etiology-Phenotype Correlation and Outcomes [PDF]

, 2021
BACKGROUND AND OBJECTIVES: Membranoproliferative GN and C3 glomerulopathy are rare and overlapping disorders associated with dysregulation of the alternative complement pathway.
Wilson, V, McLoughlin, A-C, Cooke, K, McAlinden, P, Marks, SD, Cook, HT, Goodship, THJ, Marchbank, KJ, Richardson, G, Maxwell, H, Harris, CL, MPGN/DDD/C3 Glomerulopathy Rare Disease Group and National Study, Pickering, MC, Pappworth, IY, Malcomson, R, Gale, DP, Johnson, SA, Morgan, BP, Lomax-Browne, H, Hakobyan, S, Wong, EKS, Ward, S, Kavanagh, D, Denton, H, Christian, M   +24 more
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