Results 61 to 70 of about 216,693 (188)

C3 glomerulopathies: dense deposit disease and C3 glomerulonephritis

Frontiers in Medicine, 2023
Dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are types of membranoproliferative glomerulonephritis classified as C3 glomerulopathies. These conditions are characterized by an increased number of intraglomerular cells and diffuse thickening of the glomerular capillary walls, along with the deposition of C3 and minimal or absent ...
Claudio Ponticelli, Marta Calatroni, Marta Calatroni, Gabriella Moroni, Gabriella Moroni   +4 more
openaire   +3 more sources

First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high‐quality data, expert consensus was additionally obtained through a modified Delphi process.
Giorgia Olivieri, Andrea Bordugo, Birute Burnyte, Alessandro Costetti, Maria‐Luz Couce, Luisa Diogo, Francois Feillet, D. Sean Froese, Benedetta Greco, Jean‐Louis Gueant, Luciana Hannibal, Friederike Hörster, Viktor Kožich, Giancarlo La Marca, Irini Manoli, Fanny Mochel, Lorenzo Orazi, Belén Pérez, Manuel Schiff, Bernd C. Schwahn, Ida Schwartz, Karolina M. Stepien, Jolanta Sykut‐Cegielska, Trine Tangeraas, Rolf H. Zetterström, Carlo Dionisi‐Vici, Martina Huemer   +26 more
wiley   +1 more source

COQ2‐Associated Primary Coenzyme Q10 Deficiency Presenting With Proteinuria: A Case Report and Literature Review

Molecular Genetics &Genomic Medicine, Volume 14, Issue 7, July 2026.
We report a female pediatric patient with compound heterozygous *COQ2* variants (c.368G>A, c.908A>G) presenting PCOQ10D; high‐dose CoQ10 plus enalapril maleate resolved proteinuria and preserved renal function. ABSTRACT Background Primary coenzyme Q10 (CoQ10) deficiency (PCOQ10D) is an autosomal recessive mitochondrial disorder caused by pathogenic ...
Yuqi Yue, Fei Zhao, Qiuxia Chen
wiley   +1 more source

Global Consultation for Clinical Xenotransplantation: International Xenotransplantation Association Consensus and Communiqué Update

Xenotransplantation, Volume 33, Issue 4, July/August 2026.
ABSTRACT Xenotransplantation has entered a phase of accelerated clinical translation, necessitating renewed international consensus on governance, ethics, safety, and regulatory oversight. In September 2025, the International Xenotransplantation Association (IXA), in partnership with The Transplantation Society (TTS) and with engagement from the World ...
Wayne J. Hawthorne, Eckhard Wolf, Peter J. Cowan, Wei Wang, Ik Jin Yun, Paolo Brenner, Greg Korbutt, Raphael P. H. Meier, Megan Sykes, Léo H. Bühler, Linda Scobie, Olga Garkavenko, Hyunil Kim, Daniel J. Hurst, Richard N. Pierson III, Robert Rieben, Manuel Pascual, Nicole Scholes‐Robertson, Emanuele Cozzi, Adrián Abalovich, Alexandre Loupy, Hidetaka Hara, Rita Bottino, Burcin Ekser, Muhammad M. Mohiuddin, Jay Fishman   +25 more
wiley   +1 more source

C3 Glomerulonephritis: A Rare Etiology of the Pulmonary Renal Syndrome

Kidney Medicine, 2019
C3 Glomerulopathy is a rare form of kidney disease due to dysregulation of the alternative complement pathway. We report a case of a college-aged woman with C3 glomerulonephritis (C3GN), presenting with the unexpected extrarenal manifestation of ...
Shane A. Bobart, Sanjeev Sethi, Fernando C. Fervenza   +2 more
doaj   +1 more source

Decoding the Factor H‐Related Proteins: Gatekeepers of Complement Dysregulation in AMD

European Journal of Immunology, Volume 56, Issue 6, June 2026.
This review will explore the role of the factor H‐related (FHR) proteins in age‐related macular degeneration (AMD), their accumulation in the outer blood/retinal barrier, and how they may contribute to barrier dysfunction and inflammation. ABSTRACT Age‐related macular degeneration (AMD) is the third most common form of blindness in the Western world ...
Jiaqi Tang, Nathalie Zgoda, Simon J. Clark   +2 more
wiley   +1 more source

C3 Glomerulopathy: Novel Treatment Paradigms

Kidney International Reports
C3 glomerulopathy (C3G) is diagnosed by kidney biopsy, with immunofluorescence showing isolated or dominant C3 staining, indicating hyperactivity of the alternative complement pathway as the key driver of glomerular injury.
Blanca Tarragon Estebanez, Andrew S. Bomback   +1 more
doaj   +1 more source

Multimodal imaging of retinal pigment epithelial detachments in patients with C3 glomerulopathy: case report and review of the literature

BMC Ophthalmology, 2017
Background To describe the optical coherence tomography angiograhy (OCTA) of drusenoid pigment epithelial detachments (PEDs) in a woman affected by Complement 3 (C3) glomerulopathy, which represents a spectrum of glomerular diseases characterized on ...
Valeria Kheir, Ali Dirani, Matthieu Halfon, Jean-Pierre Venetz, Georges Halabi, Yan Guex-Crosier   +5 more
doaj   +1 more source

Shifting From Systemic to Precision‐Targeted Complement Therapies: Opportunities and Hurdles

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Complement therapeutics have expanded considerably, but systemic inhibitors remain limited by infection risks, breakthrough events, and loss of physiological functions. Emerging targeted approaches aim for organ‐, tissue‐, or cell‐specific modulation of complement activity, potentially offering greater precision while reducing treatment burden and ...
Marco Mannes, Wioleta M. Zelek, Leendert A. Trouw   +2 more
wiley   +1 more source

Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN.

BACKGROUND: C3 glomerulopathy and primary immune-complex membranoproliferative glomerulonephritis (MPGN) generally result in glomerular C3 deposition and irreversible kidney damage.
Delmas, Yahsou, Han, Seung Hyeok, Mastrangelo, Antonio, Kinnman, Nils, Szamosi, Johan, Wallace, Dean, Van De Kar, Nicole, Pickering, Matthew C, Nester, Carla M, Deschatelets, Pascal, Dixon, Bradley P, Bomback, Andrew S, VALIANT Trial Investigators Group, Fakhouri, Fadi, Zecher, Daniel, Kopyt, Nelson, DO, FASN, FACP, Ariceta, Gema, Vivarelli, Marina, Mizuno, Masashi, Abad-Franch, Lydia, Remuzzi, Giuseppe, Li, Li, López-Lázaro, Luis, Le Quintrec, Moglie, Isbel, Nicole, Gale, Daniel P, Licht, Christoph, Walker, Patrick D, Wang, Zhongshen, Greenbaum, Larry A, Francois, Cedric, Neves de Holanda, Maria Izabel   +31 more
core   +6 more sources