Results 71 to 80 of about 216,693 (188)

C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases

Frontiers in Immunology, 2019
C3 glomerulopathy (C3G) is a severe kidney disease, which is caused by defective regulation of the alternative complement pathway. Disease pathogenesis is heterogeneous and is caused by both autoimmune and genetic factors.
Fei Zhao, Sara Afonso, Susanne Lindner, Andrea Hartmann, Ina Löschmann, Bo Nilsson, Kristina N. Ekdahl, Lutz T. Weber, Sandra Habbig, Gesa Schalk, Michael Kirschfink, Peter F. Zipfel, Peter F. Zipfel, Christine Skerka   +13 more
doaj   +1 more source

Randomised, phase 1 evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of iptacopan in healthy volunteers

British Journal of Pharmacology, Volume 183, Issue 11, Page 2874-2889, June 2026.
Abstract Background and Purpose Overactivation of the alternative pathway (AP) underlies several diseases. Iptacopan is an oral, first‐in‐class, highly potent specific inhibitor of factor B, a key AP protease. Experimental Approach The analysis included data from two phase 1 randomised, volunteer‐blinded, placebo‐controlled studies: Study 1, a single ...
Irina Baltcheva, Guido Junge, Kenneth Kulmatycki, Robert Schmouder, Anna Schubart, Marie‐Anne Valentin   +5 more
wiley   +1 more source

Glomerular Capillary Microaneurysms in Membranoproliferative Glomerulonephritis: A Clinicopathological Study Highlighting the Involvement of IgG3

Pathology International, Volume 76, Issue 6, June 2026.
Glomerular capillary microaneurysms (GCMs) were most frequently observed in proliferative glomerulonephritis with monoclonal immunoglobulin G deposits (PGNMID) among MPGN‐pattern glomerular diseases, but were not restricted to this entity. These lesions were characterized by exclusive IgG3‐dominant glomerular deposition, irrespective of light‐chain ...
Akiko Mii, Tomohiro Kaneko, Momoko Arai, Takehisa Yamada, Mayuko Takeuchi, Tetsuya Kashiwagi, Naomi Kuwahara, Arimi Ishikawa, Ryuji Ohashi, Yukinao Sakai, Masato Iwabu, Akira Shimizu   +11 more
wiley   +1 more source

Current concepts in C3 glomerulopathy

Indian Journal of Nephrology, 2014
Complement component 3 glomerulopathy (C3G) is a recently defined entity comprising of dense deposit disease and C3 glomerulonephritis. The key histological feature is the presence of isolated C3 deposits without immunoglobulins. Often masqueradng as some of the common glomerulonephritides this is a prototype disorder occurring from dysregulated ...
Thomas, S., Ranganathan, D., Francis, L., Madhan, K., John, G. T.   +4 more
openaire   +2 more sources

Circulating Complement Levels and C3 Glomerulopathy [PDF]

Clinical Journal of the American Society of Nephrology, 2014
The complement system is an essential part of innate immunity acting as a first-line defense against infection and provides an interface between innate and adaptive immunity ([1][1],[2][2]). It consists of a network of soluble (fluid phase) and cell membrane proteins (solid phase).
Fernando C, Fervenza, Sanjeev, Sethi
openaire   +2 more sources

PLA2R‐Positive Membranous Nephropathy and AA Amyloidosis in an Ethiopian Patient With Chronic Hepatitis B: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT The coexistence of primary phospholipase A2 receptor positive membranous nephropathy and AA amyloidosis in a patient with chronic hepatitis B is an exceedingly rare triad presenting a profound diagnostic and therapeutic challenge. A 38‐year‐old Ethiopian man with nephrotic syndrome and chronic hepatitis B had dual pathology on renal biopsy ...
Betelhem Abreham, Leja Hamza, Azeb Kebede, Daniel Rebuma Bekele, Zekarias Amdemariam   +4 more
wiley   +1 more source

Predictors of poor kidney outcome in children with C3 glomerulopathy

, 2021
Background C3 glomerulopathy (C3G) is characterized by heterogeneous clinical presentation, outcome, and predominant C3 accumulation in glomeruli without significant IgG. There is scarce outcome data regarding childhood C3G.
Cicek, Neslihan, Aksu, Bagdagul, Tabel, Yılmaz, Soylu, Alper, Tekcan, Demet, Pınarbaşı, Ayşe Seda, Düşünsel, Ruhan, PINARBAŞI, AYŞE SEDA, SAYGILI, Seha Kamil, Bakkaloğlu Ezgü, Sevcan Azime, Bayram, Meral Torun, Dönmez, Osman, Saygili, Seha, Yildirim, Zeynep Y., Dursun, İsmail, Yılmaz, Dilek, Celakil, Mehtap Ezel, Gökce, İbrahim, Çomak, Elif, Tasdemir, Mehmet, Canpolat, Nur, TABEL, YILMAZ, TORUN BAYRAM, MERAL, Melek, Engin, YILMAZ, DİLEK, Ozcelik, Gul, Benzer, Meryem, Koyun, Mustafa, Bahat Özdoğan, Elif   +28 more
core   +1 more source

Four cases of C3 glomerulopathy in children and literature review [PDF]

Linchuang erke zazhi
Objective To investigate the clinical phenotypes, pathological characteristics, genetic variants, and treatment outcomes in children with C3 glomerulopathy (C3G), and to provide evidence for precise diagnosis and management.
LI Huarong, CHEN Chaoying, TU Juan, LIN Tiantian, WANG Nannan
doaj   +1 more source

Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Local complement production by pulmonary artery adventitial fibroblasts, activated intracellularly by CFD and CFB and extracellularly by GZMK+ CD8 T cells, and its secretion in soluble form and within EVs promotes macrophage and T cell chemotaxis and activation.
Hui Zhang, Ram Raj Prasad, Sushil Kumar, Min Li, Dallas Jones, Cheng‐Jun Hu, Claudia Mickael, Yen‐Rei Yu, Rubin M. Tuder, Kurt R. Stenmark   +9 more
wiley   +1 more source

C3 glomerulopathy — understanding a rare complement-driven renal disease

, 2019
\ua9 2019, Springer Nature Limited. The C3 glomerulopathies are a group of rare kidney diseases characterized by complement dysregulation occurring in the fluid phase and in the glomerular microenvironment, which results in prominent complement C3 ...
Van der Vlag J, Fakhouri F, Sethi S, Smith RJH, Lambris JD, Kavanagh D, Noris M, Blom AM, Fremeaux-Bacchi V, Remuzzi G, Appel GB, D'Agati VD, Nester CM, Zipfel PF, Pickering MC, Cook HT, Jozsi M, de Cordoba SR   +17 more
core   +6 more sources