Results 91 to 100 of about 216,693 (188)

Factor B and C4b2a Autoantibodies in C3 Glomerulopathy

Frontiers in Immunology, 2019
C3 Glomerulopathy (C3G) is a renal disease mediated primarily by dysregulation of the alternative pathway of complement. Complement is the cornerstone of innate immunity.
Jill J. Hauer, Dingwu Shao, Yuzhou Zhang, Carla M. Nester, Richard J. H. Smith   +4 more
doaj   +1 more source

Monoclonal Antibodies for the Treatment of the C3 Glomerulopathies [PDF]

Clinical Journal of the American Society of Nephrology, 2012
Our understanding of glomerular disease has been steadily progressing from pattern-based histologic classification and empirical immunosuppressive treatments to better molecular characterization of disease and, albeit more slowly, to more targeted therapies.
openaire   +2 more sources

Proof of concept of a new plasma complement Factor H from waste plasma fraction

Frontiers in Immunology
IntroductionComplement factor H (FH) is a major regulator of the complement alternative pathway, its mutations predispose to an uncontrolled activation in the kidney and on blood cells and to secondary C3 deficiency.
Filippo Mori, Giancarlo Pascali, Giancarlo Pascali, Silvia Berra, Alessandra Lazzarotti, Daniele Panetta, Silvia Rocchiccioli, Elisa Ceccherini, Francesco Norelli, Antonio Morlando, Roberta Donadelli, Alberto Clivio, Claudio Farina, Marina Noris, Piero A. Salvadori, Giuseppe Remuzzi   +15 more
doaj   +1 more source

Ten years of C3 glomerulopathy

Cohort of 280 biopsy proven cases of C3 glomerulopathy (C3G) from 2014 to 2023 in The Netherlands. The dataset incudes the following variables: age at diagosis, patient's sex, histological disease pattern of the biopsy, primary C3G variant diagnosed ...
Overwijk, Rick, Bajema, Ingeborg
core   +1 more source

C3 Glomerulopathy

Ayehu G, Atari M, Hassanein M, Jhaveri KD.   +3 more
europepmc   +2 more sources

Properdin in C3 glomerulopathy

, 2016
24 p.-3 fig.-3 tab.Properdin (P) stabilizes the alternative pathway (AP) convertases, being the only known positive regulator of complement system. In addition, P is a pattern recognition molecule able to initiate directly the AP on non-self surfaces ...
Nozal, Pilar, Rodríguez de Córdoba, Santiago, Tortajada, Agustín, López-Trascasa, Margarita, Bravo García-Morato, María, Garrido, Sofía, Corvillo, Fernando   +6 more
core   +1 more source

C3 glomerulopathy

Nephrology Dialysis Transplantation, 2019
Koopman, J.J.E., Vries, A.P.J. de, Bajema, I.M.   +2 more
openaire   +3 more sources

C3 glomerulopathy triggered by infection-A rare case report

Asian Journal of Medical Sciences
C3 glomerulopathy (C3G) is a rare condition caused by dysregulation of the alternative complement pathway. Although a link between Group A streptococcal infection and C3G has been proposed, underlying complement abnormalities—genetic or acquired—are ...
Diksha Samsukha , Rohidas T Borse, Nagnath Redewad , Meenal Chandanwale   +3 more
doaj   +1 more source

Evolving complexity of complement-related diseases: C3 glomerulopathy and atypical haemolytic uremic syndrome

, 2018
PURPOSE OF REVIEW: The current review will discuss recent advances in our understanding of the pathology of C3 glomerulopathy and atypical haemolytic uremic syndrome (aHUS). RECENT FINDINGS: C3 glomerulopathy and aHUS are associated with abnormalities of
H. Terence Cook, Cook, H Terence
core   +1 more source

Recent advances in C3 glomerulopathy with monoclonal gammopathy

Linchuang shenzangbing zazhi
As a rare monoclonal gammopathy, C3 glomerulopathy with monoclonal gammopathy （C3G-MIg） is a major cause of renal injury in patients aged over 50 years. The key pathogenesis of C3G-MIg is that monoclonal immunoglobulins act as an autoantibody or directly
Yi-lan Cheng, Lu Zhang, Hui-ming Wang
doaj   +1 more source