Results 111 to 120 of about 6,839 (215)

Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway [PDF]

, 2017
TRPC6 plays a critical role in proteinuric kidney diseases, and TRPC3 is involved in tubulointerstitialdamage and renal fibrosis in obstructed kidneys. Podocyte loss is a characteristic event in diabetic nephropathy(DN).
Birnbaumer, Lutz, He, Xiju, Li, Shoutian, Liao, Yanhong, Liu, Benju, Xu, Benke   +5 more
core  

Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]

, 2017
IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna, Delles, Christian, Filip, Szymon, Gakiopoulou, Chara, Jankowski, Joachim, Krochmal, Magdalena, Markoska, Katerina, Mischak, Harald, Orange, Clare, Spasovski, Goce, Vlahou, Antonia, Zoidakis, Jerome   +11 more
core   +2 more sources

Proof of concept of a new plasma complement Factor H from waste plasma fraction

Frontiers in Immunology
IntroductionComplement factor H (FH) is a major regulator of the complement alternative pathway, its mutations predispose to an uncontrolled activation in the kidney and on blood cells and to secondary C3 deficiency.
Filippo Mori, Giancarlo Pascali, Giancarlo Pascali, Silvia Berra, Alessandra Lazzarotti, Daniele Panetta, Silvia Rocchiccioli, Elisa Ceccherini, Francesco Norelli, Antonio Morlando, Roberta Donadelli, Alberto Clivio, Claudio Farina, Marina Noris, Piero A. Salvadori, Giuseppe Remuzzi   +15 more
doaj   +1 more source

El Síndrome Nefrótico en la provincia de Castellón: un estudio retrospectivo de los pacientes biopsiados en el 2014 [PDF]

, 2017
Treball de Final de Grau en Medicina. Codi: MD1158. Curs acadèmic 2016-2017Antecedentes: El síndrome nefrótico (proteinuria superior a 3.5g/día, hipoproteinemia, edema generalizado e hiperlipidemias) es una manifestación de diferentes patologías. Como su
Saez Rius, Amanda
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Urine Complement Proteins and the Risk of Kidney Disease Progression and Mortality in Type 2 Diabetes. [PDF]

, 2018
ObjectiveWe examined the association of urine complement proteins with progression to end-stage renal disease (ESRD) or death in people with type 2 diabetes and proteinuric diabetic kidney disease (DKD).Research design and methodsUsing targeted mass ...
Afkarian, Maryam, Babenko, Ilona, Durbin-Johnson, Blythe, Mehrotra, Rajnish, Rocke, David M, Vaisar, Tomas, Whitlock, Kathryn   +6 more
core   +1 more source

C3 glomerulopathy triggered by infection-A rare case report

Asian Journal of Medical Sciences
C3 glomerulopathy (C3G) is a rare condition caused by dysregulation of the alternative complement pathway. Although a link between Group A streptococcal infection and C3G has been proposed, underlying complement abnormalities—genetic or acquired—are ...
Diksha Samsukha , Rohidas T Borse, Nagnath Redewad , Meenal Chandanwale   +3 more
doaj   +1 more source

World small animal veterinary association renal pathology initiative: classification of glomerular diseases in dogs [PDF]

, 2015
Aresu, L, Brovida, C, Brown, C A, Cianciolo, R E, Cowgill, L D, Heiene, R, James, C, Jansen, J H, Kass, PH, Lees, G E, Mohr, F C, Polzin, D J, Spangler, W L, Syme, H M, Vaden, S L, van de Lugt, JJ, van Dongen, A M   +16 more
core   +2 more sources

Diabetes Mellitus and Renal Disease: When to Perform a Renal Biopsy? [PDF]

, 2009
Background: Several studies suggest that nondiabetic renal disease (NDRD) is common in patients with diabetes mellitus. The aim of this analysis of renal biopsies in diabetic patients was (a) to assess the prevalence and type of NDRD and (b) to identify ...
Carvalho, F, Matias, P, Ribeiro Santos, J, Viana, H   +3 more
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C3 glomerulopathy

Nephrology Dialysis Transplantation, 2019
Koopman, J.J.E., Vries, A.P.J. de, Bajema, I.M.   +2 more
openaire   +3 more sources

Recent advances in C3 glomerulopathy with monoclonal gammopathy

Linchuang shenzangbing zazhi
As a rare monoclonal gammopathy, C3 glomerulopathy with monoclonal gammopathy （C3G-MIg） is a major cause of renal injury in patients aged over 50 years. The key pathogenesis of C3G-MIg is that monoclonal immunoglobulins act as an autoantibody or directly
Yi-lan Cheng, Lu Zhang, Hui-ming Wang
doaj   +1 more source