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Engineering TME-activated CD47-specific CAR macrophage via Arg1 promoter for safe and effective solid tumor immunotherapy. [PDF]
J Immunother CancerDu F +13 more
europepmc +1 more source
Functional Analysis of CD47/IAP in Cultured Central Nervous System Neurons [PDF]
コシミズ, ヒサツグ +1 more
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Advanced Materials, 2023
Immunomodulation of tumor‐associated macrophages (TAMs) into tumor‐inhibiting M1‐like phenotype is a promising but challenging strategy. Cleverly, tumor cells overexpress CD47, a “don't eat me” signal that ligates with the signal regulatory protein alpha
Xing-Jie Liang
exaly +2 more sources
Immunomodulation of tumor‐associated macrophages (TAMs) into tumor‐inhibiting M1‐like phenotype is a promising but challenging strategy. Cleverly, tumor cells overexpress CD47, a “don't eat me” signal that ligates with the signal regulatory protein alpha
Xing-Jie Liang
exaly +2 more sources
Arteriosclerosis, Thrombosis, and Vascular Biology, 2008 CD47, originally named integrin-associated protein, is a receptor for thrombospondin-1. A number of important roles for CD47 have been defined in regulating the migration, proliferation, and survival of vascular cells, and in regulation of innate and adaptive immunity.
David D Roberts
exaly +4 more sources
Cancer Letters, 2023
Cross-talk between the tumor microenvironment (TME) and cancer cells plays an important role in acquired drug resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs).
Jia-Yin Lu +16 more
semanticscholar +1 more source
Cross-talk between the tumor microenvironment (TME) and cancer cells plays an important role in acquired drug resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs).
Jia-Yin Lu +16 more
semanticscholar +1 more source
CD47 Peptide-Cloaked Lipid Nanoparticles Promote Cell-Specific mRNA Delivery.
Molecular TherapymRNA-based therapeutics delivered via lipid nanoparticles (LNP-mRNA) hold great promise for treating diverse diseases. However, further improvements are needed to refine outcomes in non-vaccine, extrahepatic applications, such as minimizing the ...
T. Papp +15 more
semanticscholar +1 more source
Life Sciences, 2020
CD47 (cluster of differentiation 47) is a ubiquitously expressed transmembrane protein that belongs to the immunoglobulin superfamily. CD47 is both a receptor for the matricellular protein thrombospondin-1 (TSP-1) and a ligand for signal-regulatory protein alpha (SIRPα).
Quanli, Cheng +4 more
openaire +2 more sources
CD47 (cluster of differentiation 47) is a ubiquitously expressed transmembrane protein that belongs to the immunoglobulin superfamily. CD47 is both a receptor for the matricellular protein thrombospondin-1 (TSP-1) and a ligand for signal-regulatory protein alpha (SIRPα).
Quanli, Cheng +4 more
openaire +2 more sources
USP2 inhibition unleashes CD47-restrained phagocytosis and enhances anti-tumor immunity
Nature CommunicationsThe CD47/SIRPα axis conveys a ‘don’t eat me’ signal, thereby thwarting the phagocytic clearance of tumor cells. Although blocking antibodies targeting CD47 have demonstrated promising anti-tumor effects in preclinical models, clinical trials involving ...
Panpan Dai +23 more
semanticscholar +1 more source
ACS Nano, 2023
Enabling macrophages to phagocytose tumor cells holds great potential for cancer therapy but suffers from tremendous challenges because the tumor cells upregulate antiphagocytosis molecules (such as CD47) on their surface.
Jia-Qi Luo +6 more
semanticscholar +1 more source
Enabling macrophages to phagocytose tumor cells holds great potential for cancer therapy but suffers from tremendous challenges because the tumor cells upregulate antiphagocytosis molecules (such as CD47) on their surface.
Jia-Qi Luo +6 more
semanticscholar +1 more source