Results 201 to 210 of about 306,421 (309)

Carbohydrate fatty acid monosulphate ester adjuvant enhances the immunogenicity of influenza antigens <i>via</i> TLR4/2-dependent mechanisms. [PDF]

Front Immunol
Retnakumar SV, Singh SC, Bonam SR, Chauvin C, Mathew MJ, Nielsen IB, Boyle C, Hilgers L, Søgaard M, Platenburg PP, Bayry J.   +10 more
europepmc   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Mixed Signals: T Cells as Architects of IgE Immunity. [PDF]

Immunol Rev
Tierney AL, Bezerra WP, Eisenbarth SC, Williams A.   +3 more
europepmc   +1 more source

Natural cutaneous anthrax infection, but not vaccination, induces a CD4(+) T cell response involving diverse cytokines. [PDF]

, 2015
Altmann, DM, Ascough, S, Baillie, L, Boyton, RJ, Doganay, M, Ingram, RJ, Maillere, B, Metan, G, Reynolds, CJ, Robinson, JH, Williamson, DE   +10 more
core   +1 more source

Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance

Advanced Science, EarlyView.
A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou, Ke Li, Xuelan Li, Lei Yi, Zhengxiang Wang, Huan Ding, Sheng Wu, Feiyu Liu, Yuan Li, Rui Cheng, Jianliang Shen   +10 more
wiley   +1 more source

Dietary Antigen Interaction with Intestinal Epithelial Cells. [PDF]

Curr Allergy Asthma Rep
Reichel PE, Chakraborty S, Tay HL, Hogan SP.   +3 more
europepmc   +1 more source

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source

Dendritic cells in hematologic malignancies: a brief review of immunoregulation to new perspectives. [PDF]

Biochem Med (Zagreb)
de Almeida GB, Dos Santos MM, de Oliveira Barbosa D, Conceição RR, de Almeida Lopes B, de Melo Santos HH, Marchioro SB.   +6 more
europepmc   +1 more source

scResponse: A Rank‐Based Method for Identifying Cell States That Contribute to Immunotherapy Response by Single‐Cell Data

Advanced Science, EarlyView.
Although the tumor microenvironment is known to shape immunotherapy response, its key determinants remain elusive, underscoring the critical need for single‐cell resolution analytical frameworks. We present scResponse, an efficient algorithm to quantify single‐cell responses to immunotherapy. By capturing diverse cellular subtypes and states associated
Qi Dong, Haijun Huang, Yuxiu Wang, Bo Jiang, Yuzheng Chen, Huanhuan Xu, Jing Ren, Shengnan Guo, Tianhao Li, Mingjie Zhang, Tianyu Zhai, Wenbo Yang, Kaidong Liu, Cheng Lyu, Jingxuan Kang, Mingshuo Zhang, Yupeng Lu, Binghui Si, Shujun Cao, Dandan Xu, Zong Chen, Dapeng Hao   +21 more
wiley   +1 more source

The dual role of T cells in solid organ transplant rejection and immune tolerance. [PDF]

Front Immunol
Zhang Z, Zhao N, Miao Y, Sun Y, Liu C, Cao N, Liu C, Ding Y, Li J, Li N.   +9 more
europepmc   +1 more source