Results 151 to 160 of about 6,819 (179)

Expression of 17-1A antigen and complement resistance factors CD55 and CD59 on liver metastasis in colorectal cancer

Journal of Gastrointestinal Surgery, 2001
Despite radical surgery, the prognosis for colorectal cancer patients with liver metastases has not changed markedly. Furthermore, no standard adjuvant therapeutic regimen has been developed. Adjuvant therapy with monoclonal antibodies (e.g., against 17-1A), which has been shown to be effective in preventing metastatic relapse in patients with Dukes' C
S B, Hosch, P, Scheunemann, M, Lüth, S, Inndorf, N H, Stoecklein, A, Erbersdobler, A, Rehders, M, Gundlach, W T, Knoefel, J R, Izbicki   +9 more
openaire   +2 more sources

Identification of MIC 11 antigen as an epitope of the CD59 molecule.

Immunology, 1995
The MIC 11 antigen is expressed on human cells and is characterized by reaction with a monoclonal antibody (mAb), 16.3A5. The gene controlling MIC 11 was recently mapped to the p13 region of chromosome 11 within 500 kb of the gene encoding CD59, a complement regulatory protein.
A, Davies, A B, Wilson, J C, Bramley, C, Willers, V, Van Heyningen, W A, Bickmore, P J, Lachmann   +6 more
openaire   +1 more source

CD59: a molecule involved in antigen presentation as well as downregulation of membrane attack complex.

Experimental and clinical immunogenetics, 1992
CD59 is a recently discovered complement (C) regulatory protein. Three activities of CD59 have been recognized so far. It can downregulate the activation of the C cascade at membrane attack complex formation stage, it participates in T-cell rosette formation with erythrocytes and appears to be necessary for T-cell activation.
G T, Venneker, S S, Asghar
openaire   +1 more source

Modulation of protectin (CD59 antigen) cell surface expression on human neoplastic cell lines.

Neoplasma, 1994
The ability of cytokines (IFN alpha, IFN gamma, TNF alpha, IL-1 alpha, IL-6), all-trans retinoic acid, 1,25(OH)2-vitamin D3 and the tumor promoting phorbol ester TPA to regulate cell surface expression of protectin (CD59 antigen) on human hematopoietic and non-hematopoietic neoplastic cell lines was examined with the aid of immunocytofluorometric ...
J, Sedlák, L, Hunáková, J, Duraj, M, Grófová, B, Chorváth   +4 more
openaire   +1 more source

CD59 is a blood group antigen

Molecular Immunology, 2013
M. Anliker, I. von Zabern, B. Höchsmann, C. Dohna-Schwake, H. Kyrieleis, H. Schrezenmeier, C. Weinstock   +6 more
openaire   +2 more sources

Characterization of the membrane attack complex inhibitory protein CD59 antigen on human amniotic cells and in amniotic fluid.

Immunology, 1992
A functional complement system and the potential for its activation are present in human amniotic fluid. We have recently demonstrated that CD59 antigen is present and functionally active on human amniotic epithelial cells (HAEC). We have now further examined the role of this protein on HAEC and have also demonstrated its presence in amniotic fluid (AF)
I A, Rooney, B P, Morgan
openaire   +1 more source

Monoclonal antibodies to two adhesive cell surface antigens (CD43 and CD59) with different distribution on hematopoietic and non-hematopoietic tumor cell lines.

Neoplasma, 1993
Two new murine monoclonal antibodies were prepared by hybridoma technique after immunization with the immature pluripotent leukemia cell line K562. The monoclonal antibody Bra10G (IgG2b) reacted in a non-lineage pattern with all examined hematopoietic neoplastic cell lines and peripheral blood cells (granulocytes, lymphocytes, erythrocytes) of healthy ...
B, Chorváth, L, Hunáková, M, Turzová, M, Sulíková, J, Duraj, P, Speiser, J, Sedlák   +6 more
openaire   +1 more source

Antigen S1, encoded by the MIC1 gene, is characterized as an epitope of human CD59, enabling measurement of mutagen-induced intragenic deletions in the AL cell system.

Somatic cell and molecular genetics, 2001
S1 cell membrane antigen is encoded by the MIC1 gene on human chromosome 11. This antigen has been widely used as a marker for studies in gene mapping or in analysis of mutagen-induced gene deletions/mutations, which utilized the human-hamster hybrid cell-line, AL-J1, carrying human chromosome 11.
A B, Wilson, D, Seilly, C, Willers, D B, Vannais, M, McGraw, C A, Waldren, T K, Hei, A, Davies   +7 more
openaire   +1 more source

Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Proceedings of the National Academy of Sciences of the United States of America, 2022
Ewelina Golec, Alexander Ekstrom, Muhmmad Omar-Hmeadi   +2 more
exaly  

The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus

Cell Reports, 2023
Xiaoli Yang, Zuolong Chen, Yong Shen
exaly