Results 1 to 10 of about 49,530 (262)

Immunomodulator Testing on Ethanol Extract of Gynura procumbens Leaves to Mus musculus Adaptive Immune System: in Vitro Study [PDF]

Journal of Experimental Life Science, 2014
Immunomodulator is a substance that has an ability to modulate the activity and function of immune system. Gynura procumbens supposed to has benefit as an immunomodulator because of it afficacy to cure many diseases. The aim of this study is to determine
Dinia Rizqi Dwijayanti, Muhaimin Rifa'i
doaj   +4 more sources

CD62L expression marks a functionally distinct subset of memory B cells

Cell Reports, 2023
Summary: The memory B cell response consists of phenotypically distinct subsets that differ in their ability to respond upon antigen re-encounter.
Christopher H. Hanson, Brittany Henry, Pradhnesh Andhare, Frank J. Lin, Haley Pak, Jackson S. Turner, Lucas J. Adams, Tom Liu, Daved H. Fremont, Ali H. Ellebedy, Brian J. Laidlaw   +10 more
doaj   +4 more sources

Diabetes exacerbates myasthenia gravis by enhancing pathological thymic output via the GPR183-7α,25-OHC axis [PDF]

Journal of Neuroinflammation
Background Diabetes mellitus (DM) could exacerbate experimental autoimmune myasthenia gravis (EAMG) by affecting both the innate and adaptive immune systems, although the specific mechanism remains unclear.
Jing Dong, Xin Shi, Xu-dong Gu, Ying Yang, Yi-Lin He, Yang Zhou, Heng Li, Tong Du, Wei-yue Si, Shu-li Wei, Chang Liu, Bing Yang, Yan-bin Li, Rui-Sheng Duan, Chun-Lin Yang, Peng Zhang   +15 more
doaj   +2 more sources

The shedding of CD62L (L-selectin) regulates the acquisition of lytic activity in human tumor reactive T lymphocytes. [PDF]

PLoS ONE, 2011
CD62L/L-selectin is a marker found on naïve T cells and further distinguishes central memory (Tcm, CD62L+) from effector memory (Tem, CD62L-) T cells. The regulation of CD62L plays a pivotal role in controlling the traffic of T lymphocytes to and from ...
Shicheng Yang, Fang Liu, Qiong J Wang, Steven A Rosenberg, Richard A Morgan   +4 more
doaj   +1 more source

Increased CD11b and Decreased CD62L in Blood and Airway Neutrophils from Long-Term Smokers with and without COPD

Journal of Innate Immunity, 2020
There is incomplete mechanistic understanding of the mobilization of neutrophils in the systemic and local compartment in smokers with chronic obstructive pulmonary disease (COPD).
Marit Stockfelt, Karin Christenson, Anders Andersson, Lena Björkman, Médea Padra, Bettina Brundin, Koustav Ganguly, Helga Asgeirsdottir, Sara Lindén, Ingemar Qvarfordt, Johan Bylund, Anders Lindén   +11 more
doaj   +1 more source

L-Selectin/CD62L Is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men

Cells, 2020
CD62L (L-Selectin) dependent lymphocyte infiltration is known to induce inflammatory bowel disease (IBD), while its function in the liver, especially in non-alcoholic steatohepatitis (NASH), remains unclear.
Hannah K. Drescher, Angela Schippers, Stefanie Rosenhain, Felix Gremse, Laura Bongiovanni, Alain de Bruin, Sreepradha Eswaran, Suchira U. Gallage, Dominik Pfister, Marta Szydlowska, Mathias Heikenwalder, Sabine Weiskirchen, Norbert Wagner, Christian Trautwein, Ralf Weiskirchen, Daniela C. Kroy   +15 more
doaj   +1 more source

Impaired tissue homing by the Ikzf3N159S variant is mediated by interfering with Ikaros function

Frontiers in Immunology, 2023
AIOLOS, encoded by IKZF3, is a member of the IKZF family of proteins that plays an important role in regulating late B-cell differentiation. Human individuals heterozygous for the AIOLOS p.N160S variant displayed impaired humoral immune responses as well
Jingjie Chang, Motoi Yamashita, Motoi Yamashita, Aditya K. Padhi, Kam Y. J. Zhang, Ichiro Taniuchi   +5 more
doaj   +1 more source

Elicited soybean extract attenuates proinflammatory cytokines expression by modulating TLR3/TLR4 activation in high−fat, high−fructose diet mice

Journal of Ayurveda and Integrative Medicine, 2021
Background: The high−fat, high−fructose diet (HFFD) provokes overnutrition and inflammation directly, mainly through Toll−like receptors (TLRs). Soybean (Glycine max L.) contains isoflavone that can be transformed into glyceollin by microbial and ...
Mochammad Fitri Atho’illah, Yunita Diyah Safitri, Farida Dewi Nur’aini, Sri Widyarti, Hideo Tsuboi, Muhaimin Rifa’i   +5 more
doaj   +1 more source

Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin. [PDF]

, 2012
Expression of the cell-surface antigen CD10 has long been used to define the lymphoid commitment of human cells. Here we report a unique lymphoid-primed population in human bone marrow that was generated from hematopoietic stem cells (HSCs) before onset ...
Crooks, Gay M, Ge, Shundi, Hao, Qian-Lin, Kohn, Lisa A, Mikkola, Hanna KA, Parekh, Chintan, Sasidharan, Rajkumar, Zhu, Yuhua   +7 more
core   +1 more source

IMPACT OF HIV INFECTION AND TUBERCULOSIS ON THE PERIPHERAL BLOOD T-CELL DIFFERENTIATION

Инфекция и иммунитет, 2017
Tuberculosis is the leading cause of death among HIV infected individuals. In this regard, an important task is the timely detection of tuberculosis in HIV infected patients.
E. V. Vasileva, I. V. Kudryavtsev, G. V. Maximov, V. N. Verbov, M. K. Serebriakova, A. P. Tkachuk, Areg A. Totolian   +6 more
doaj   +1 more source