Systematic Review and Meta-Analysis of the Effect of Statins on Circulating E-Selectin, L-Selectin, and P-Selectin [PDF]
Biomedicines, 2021 The pleiotropic effects of statins might involve preventing inflammatory cell adhesion to the endothelium, which is a critical step in the pathogenesis of atherosclerosis.
Angelo Zinellu, Arduino A. Mangoni
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Immune Responses to IAV Infection and the Roles of L-Selectin and ADAM17 in Lymphocyte Homing [PDF]
Pathogens, 2022 Influenza A virus (IAV) infection is a global public health burden causing up to 650,000 deaths per year. Yearly vaccination programmes and anti-viral drugs currently have limited benefits; therefore, research into IAV is fundamental.
Sophie G. Reed, Ann Ager
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The Role of L-Selectin in HIV Infection [PDF]
Frontiers in Microbiology, 2021 HIV envelope glycoprotein is the most heavily glycosylated viral protein complex identified with over 20 glycans on its surface. This glycan canopy is thought to primarily shield the virus from host immune recognition as glycans are poor immunogens in ...
Jason Segura +6 more
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L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy [PDF]
Frontiers in Immunology, 2019 The homing molecule, L-selectin (CD62L), is commonly used as a T cell activation marker, since expression is downregulated following engagement of the T cell receptor.
H. Angharad Watson +13 more
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L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling [PDF]
Frontiers in Immunology, 2019 L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has been extensively characterized as a tethering/rolling receptor.
Aleksandar Ivetic +2 more
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Single-Step Purification of Monomeric l-Selectin via Aptamer Affinity Chromatography [PDF]
Sensors, 2017 l-selectin is a transmembrane receptor expressed on the surface of white blood cells and responsible for the tethering of leukocytes to vascular endothelial cells.
Christian Kuehne +2 more
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Urine L-selectin reflects clinical and histological renal disease activity and treatment response in lupus nephritis across multi-ethnicity [PDF]
Frontiers in Immunology, 2023 ObjectiveThere is an urgent need for novel biomarkers in lupus nephritis (LN). We report a non-invasive urinary biomarker, L-selectin, in two independent multi-ethnic cohorts.MethodsuL-selectin was tested cross-sectionally in a Chinese cohort (n=255) and
Yiwei Shen +23 more
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Serine Phosphorylation of L-Selectin Regulates ERM Binding, Clustering, and Monocyte Protrusion in Transendothelial Migration [PDF]
Frontiers in Immunology, 2019 The migration of circulating leukocytes toward damaged tissue is absolutely fundamental to the inflammatory response, and transendothelial migration (TEM) describes the first cellular barrier that is breached in this process.
Abigail Newe +9 more
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Tetraspanin CD53 Promotes Lymphocyte Recirculation by Stabilizing L-Selectin Surface Expression [PDF]
iScience, 2020 Summary: Tetraspanins regulate key processes in immune cells; however, the function of the leukocyte-restricted tetraspanin CD53 is unknown. Here we show that CD53 is essential for lymphocyte recirculation.
Maria C. Demaria +17 more
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The association of cell adhesion molecules and selectins (VCAM-1, ICAM-1, E-selectin, L-selectin, and P-selectin) with microvascular complications in patients with type 2 diabetes: A follow-up study [PDF]
Frontiers in Endocrinology, 2023 ObjectiveChronic hyperglycemia induces pathogenic changes in the vascular endothelium and leads to the development of microvascular complications in patients with type 2 diabetes mellitus.
Khalid Siddiqui +8 more
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