Facile supermolecular aptamer inhibitors of L-selectin. [PDF]
PLoS ONE, 2015 Multivalent interactions occur frequently in nature, where they mediate high-affinity interactions between cells, proteins, or molecules. Here, we report on a method to generate multivalent aptamers (Multi-Aptamers) that target L-selectin function using ...
Elizabeth K Chang +6 more
doaj +7 more sources
L-selectin-dependent and -independent homing of naïve lymphocytes through the lung draining lymph node support T cell response to pulmonary Mycobacterium tuberculosis infection. [PDF]
PLoS Pathogens, 2023 Recruiting large numbers of naïve lymphocytes to lymph nodes is critical for mounting an effective adaptive immune response. While most naïve lymphocytes utilize homing molecule L-selectin to enter lymph nodes, some circulating cells can traffic to the ...
Lina Daniel +5 more
doaj +2 more sources
ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. [PDF]
Sci Rep, 2019 L-selectin on T-cells is best known as an adhesion molecule that supports recruitment of blood-borne naïve and central memory cells into lymph nodes.
Mohammed RN +21 more
europepmc +6 more sources
A cell-extrinsic ligand acquired by activated T cells in lymph node can bridge L-selectin and P-selectin. [PDF]
PLoS ONE, 2018 P-selectin expressed on activated endothelia and platelets supports recruitment of leukocytes expressing P-selectin ligand to sites of inflammation.
Douglas A Carlow +2 more
doaj +2 more sources
Highly glycosylated MUC1 mediates high affinity L-selectin binding at the human endometrial surface [PDF]
Journal of Nanobiotechnology, 2021 Background Sialyl-Lewis X/L-selectin high affinity binding interactions between transmembrane O-glycosylated mucins proteins and the embryo have been implicated in implantation processes within the human reproductive system.
Lewis W. Francis +13 more
doaj +2 more sources
Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and CCR7 [PDF]
Frontiers in Immunology, 2019 Normal function of the adaptive immune system requires trafficking of T cells between the blood and lymphoid organs. Lymphocyte homing to lymph nodes requires that they cross endothelial barriers present in blood vessels and lymphatics.
Ana Dios-Esponera +4 more
doaj +2 more sources
HIV-1 targets L-selectin for adhesion and induces its shedding for viral release [PDF]
Nature Communications, 2018 HIV binding is mediated via CD4 and chemokine co-receptors, but this does not explain the preferential infection of central memory CD4+ T cells. Here the authors show HIV targets L-selectin, induces shedding from the infected cell, and inhibition of L ...
Joseph Kononchik +15 more
doaj +2 more sources
Plasma soluble L-selectin in medicated patients with schizophrenia and healthy controls. [PDF]
PLoS ONE, 2017 Immune dysfunction has been implicated in the pathophysiology of schizophrenia. Leukocyte migration to the site of inflammation is a fundamental step of immune response which involves P-, E-, and L-selectins.
Satyajit Mohite +10 more
doaj +2 more sources
L-selectin regulates human neutrophil transendothelial migration. [PDF]
J Cell Sci, 2021 ABSTRACT The migration of circulating neutrophils towards damaged or infected tissue is absolutely critical to the inflammatory response. L-selectin is a cell adhesion molecule abundantly expressed on circulating neutrophils. For over two decades, neutrophil L-selectin has been assigned the exclusive role of supporting tethering and ...
Rahman I +11 more
europepmc +6 more sources
Dynamic biochemical tissue analysis detects functional L-selectin ligands on colon cancer tissues. [PDF]
PLoS ONE, 2017 A growing body of evidence suggests that L-selectin ligands presented on circulating tumor cells facilitate metastasis by binding L-selectin presented on leukocytes. Commonly used methods for detecting L-selectin ligands on tissues, e.g., immunostaining,
Grady E Carlson +6 more
doaj +1 more source