A cell-extrinsic ligand acquired by activated T cells in lymph node can bridge L-selectin and P-selectin. [PDF]
PLoS ONE, 2018 P-selectin expressed on activated endothelia and platelets supports recruitment of leukocytes expressing P-selectin ligand to sites of inflammation.
Douglas A Carlow +2 more
doaj +3 more sources
Synthetic Glycoprotein Mimics Inhibit L-Selectin-Mediated Rolling and Promote L-Selectin Shedding [PDF]
Chemistry & Biology, 2004 L-selectin is a leukocyte cell-surface protein that facilitates the rolling of leukocytes along the endothelium, a process that leads to leukocyte migration to a site of infection. Preventing L-selectin-mediated rolling minimizes leukocyte adhesion and extravasation; therefore, compounds that inhibit rolling may act as anti-inflammatory agents.
Mowery, Patricia +6 more
core +5 more sources
P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces. [PDF]
PLoS ONE, 2013 Interactions of selectins with cell surface glycoconjugates mediate the first step of the adhesion and signaling cascade that recruits circulating leukocytes to sites of infection or injury.
Yan Zhang +5 more
doaj +2 more sources
L-Selectin Shedding Regulates Leukocyte Recruitment [PDF]
Journal of Experimental Medicine, 2001 The physiologic role of L-selectin shedding is unknown. Here, we investigate the effect of L-selectin shedding on firm adhesion and transmigration. In a tumor necrosis factor α–induced model of inflammation, inhibition of L-selectin shedding significantly increased firm adhesion and transmigration by a lymphocyte function–associated antigen (LFA)-1 and
Klaus F. Ley +2 more
exaly +3 more sources
Highly glycosylated MUC1 mediates high affinity L-selectin binding at the human endometrial surface [PDF]
Journal of Nanobiotechnology, 2021 Background Sialyl-Lewis X/L-selectin high affinity binding interactions between transmembrane O-glycosylated mucins proteins and the embryo have been implicated in implantation processes within the human reproductive system.
Lewis W. Francis +13 more
doaj +2 more sources
Chemoattractant Receptor-induced Phosphorylation of L-selectin [PDF]
Journal of Biological Chemistry, 1997 The selectin adhesion molecules and chemoattractant receptors synergistically regulate leukocyte migration into lymphoid tissues and sites of inflammation, but little is known about how these families of receptors modulate each other's function. In this study, L-selectin was found to be phosphorylated in lymphoblastoid cell lines, and phosphorylation ...
Haribabu, Bodduluri +5 more
openaire +5 more sources
L-selectin and skin damage in systemic sclerosis.
PLoS ONE, 2012 BackgroundL-selectin ligands are induced on the endothelium of inflammatory sites. L-selectin expression on neutrophils and monocytes may mediate the primary adhesion of these cells at sites of inflammation by mediating the leukocyte-leukocyte ...
James V Dunne +2 more
doaj +4 more sources
Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and CCR7 [PDF]
Frontiers in Immunology, 2019 Normal function of the adaptive immune system requires trafficking of T cells between the blood and lymphoid organs. Lymphocyte homing to lymph nodes requires that they cross endothelial barriers present in blood vessels and lymphatics.
Ana Dios-Esponera +4 more
doaj +2 more sources
L-selectin — a signalling receptor for lipopolysaccharide [PDF]
Chemistry & Biology, 1997 The activation of leukocytes by bacterial cell-wall lipopolysaccharide contributes to the pathogenesis of septic shock. We propose that in neutrophils, and possibly other leukocytes, L-selectin can act as a low-affinity lipopolysaccharide receptor.
Malhotra, Rajneesh, Bird, Michael I.
openaire +3 more sources
HIV-1 targets L-selectin for adhesion and induces its shedding for viral release [PDF]
Nature Communications, 2018 HIV binding is mediated via CD4 and chemokine co-receptors, but this does not explain the preferential infection of central memory CD4+ T cells. Here the authors show HIV targets L-selectin, induces shedding from the infected cell, and inhibition of L ...
Joseph Kononchik +15 more
doaj +2 more sources