Plasma soluble L-selectin in medicated patients with schizophrenia and healthy controls. [PDF]
PLoS ONE, 2017 Immune dysfunction has been implicated in the pathophysiology of schizophrenia. Leukocyte migration to the site of inflammation is a fundamental step of immune response which involves P-, E-, and L-selectins.
Satyajit Mohite +10 more
doaj +2 more sources
Eosinophil adhesion to nasal polyp endothelium is P-selectin-dependent.
, 1994 Tissue eosinophilia is a characteristic feature of a number of inflammatory diseases including asthma and nasal polyposis. Eosinophil migration into tissues is controlled in part by interactions between eosinophil adhesion receptors and counter ...
Fiona A. Symon (7618805) +7 more
core +7 more sources
L-selectin regulates human neutrophil transendothelial migration. [PDF]
J Cell Sci, 2021 The migration of circulating neutrophils towards damage/infected tissue is absolutely critical to the inflammatory response. L-selectin is a cell adhesion molecule abundantly expressed on circulating neutrophils.
Rahman I +11 more
europepmc +3 more sources
Dynamic biochemical tissue analysis detects functional L-selectin ligands on colon cancer tissues. [PDF]
PLoS ONE, 2017 A growing body of evidence suggests that L-selectin ligands presented on circulating tumor cells facilitate metastasis by binding L-selectin presented on leukocytes. Commonly used methods for detecting L-selectin ligands on tissues, e.g., immunostaining,
Grady E Carlson +6 more
doaj +1 more source
The Cytoplasmic Domain of L-Selectin Participates in Regulating L-Selectin Endoproteolysis [PDF]
The Journal of Immunology, 2001 Abstract Neutrophil recruitment at sites of inflammation is regulated by a series of adhesion and activation events. L-selectin (CD62L) is a leukocyte expressed adhesion protein that is important for neutrophil accumulation and rolling along the vascular endothelium.
E, Matala +3 more
openaire +2 more sources
Calmodulin adopts an extended conformation when interacting with L-selectin in membranes. [PDF]
PLoS ONE, 2013 Calmodulin, an intracellular calcium-binding protein, is thought to regulate ectodomain shedding of many membrane proteins, but the underlying molecular mechanism has remained unclear.
Wei Deng, John A Putkey, Renhao Li
doaj +1 more source
The Journal of Immunology, 2006 By 1983, when the article by Gallatin, Weissman, and Butcher ([1][1]) was published in Nature , it was clear that blood-borne lymphocytes migrate selectively (“home”) to secondary lymphoid organs.
openaire +2 more sources
Role of P-selectin in platelet sequestration in pulmonary capillaries during endotoxemia [PDF]
, 2006 Background: There is growing evidence that platelets accumulate in the lung and contribute to the pathogenesis of acute lung injury during endotoxemia.
Schenkat, Sonja +4 more
core +1 more source
Interaction of Calmodulin with l-Selectin at the Membrane Interface: Implication on the Regulation of l-Selectin Shedding [PDF]
Journal of Molecular Biology, 2011 The calmodulin (CaM) hypothesis of ectodomain shedding stipulates that CaM, an intracellular Ca²⁺-dependent regulatory protein, associates with the cytoplasmic domain of L-selectin to regulate ectodomain shedding of L-selectin on the other side of the plasma membrane.
Wei, Deng +4 more
openaire +2 more sources
Frontiers in Medicine, 2020 Selectins [endothelial (E), platelet (P), and leucocytes (L)] are a class of cell adhesion molecules, stimulated in response to inflammation. Pre-eclampsia is characterized by inflammation, and angiotensin II is pro-inflammatory.
Hiten D. Mistry +5 more
doaj +1 more source