Results 31 to 40 of about 13,368,448 (174)

Transcriptional regulation of mouse l-selectin [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2009
L-selectin mediates the initial tethering and rolling of lymphocytes in high endothelial venules. To study the transcriptional regulation of mouse L-selectin, we cloned 4.5 kb 5'-flanking sequences of the mouse sell. Luciferase analysis of serial 5'-deletion mutants showed that the first 285 bp was sufficient to drive high promoter activity in EL4 ...
Xitong, Dang, Nikolai A, Raffler, Klaus, Ley   +2 more
openaire   +2 more sources

Dysregulation of Biomarkers of Hemostatic Activation and Inflammatory Processes are Associated with Adverse Outcomes in Pulmonary Embolism

Clinical and Applied Thrombosis/Hemostasis, 2022
Introduction The pathophysiology of pulmonary embolism (PE) represents complex, multifactorial processes involving blood cells, vascular endothelium, and the activation of inflammatory pathways.
Iman Darwish B.S., Jawed Fareed PhD, Yevgeniy Brailovsky D.O., Debra Hoppensteadt PhD, Brett Slajus M.P.H., Emily Bontekoe B.S., Frank De Stefano B.S., Trent Reed D.O., Amir Darki MSc., M.D.   +8 more
doaj   +1 more source

L-Selectin-deficient SJL and C57BL/6 mice are not resistant to experimental autoimmune encephalomyelitis [PDF]

, 2008
L-selectin has been suggested to play a role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis.
Axinia Döring, Uboldi, Chiara, Estess, Pila, Siegelman, Mark, Engelhardt, Britta, Pila Estess, Mark Siegelman, Alt, Carsten, Britta Engelhardt, Chiara Uboldi, Döring, Axinia, Carsten Alt   +11 more
core   +1 more source

L-selectin Is Essential for Delivery of Activated CD8+ T Cells to Virus-Infected Organs for Protective Immunity

Cell Reports, 2016
Cytotoxic CD8+ T lymphocytes play a critical role in the host response to infection by viruses. The ability to secrete cytotoxic chemicals and cytokines is considered pivotal for eliminating virus. Of equal importance is how effector CD8+ T cells home to
Rebar N. Mohammed, H. Angharad Watson, Miriam Vigar, Julia Ohme, Amanda Thomson, Ian R. Humphreys, Ann Ager   +6 more
doaj   +1 more source

Serum E-selectin and endothelial cell-specific Molecule-1 levels among people living with HIV on long term ART in Uganda: a pilot cross-sectional study

AIDS Research and Therapy, 2023
Background Prolonged exposure to HIV and anti-retroviral therapy (ART) has been linked with endothelial cell activation which subsequently predisposes people living with HIV (PLWH) to cardiovascular diseases.
Andrew Weil Semulimi, Charles Batte, Alice Bayiyana, Mariam Nakabuye, John Mukisa, Barbara Castelnuovo, Rosalind Parkes Ratanshi, Bruce J Kirenga, Isaac Ssinabulya   +8 more
doaj   +1 more source

Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes

eLife, 2016
Myeloid-derived suppressor cells (MDSC) contribute to an immunosuppressive network that drives cancer escape by disabling T cell adaptive immunity. The prevailing view is that MDSC-mediated immunosuppression is restricted to tissues where MDSC co-mingle ...
Amy W Ku, Jason B Muhitch, Colin A Powers, Michael Diehl, Minhyung Kim, Daniel T Fisher, Anand P Sharda, Virginia K Clements, Kieran O'Loughlin, Hans Minderman, Michelle N Messmer, Jing Ma, Joseph J Skitzki, Douglas A Steeber, Bruce Walcheck, Suzanne Ostrand-Rosenberg, Scott I Abrams, Sharon S Evans   +17 more
doaj   +1 more source

Stem Cell Enrichment with Selectin Receptors: Mimicking the pH Environment of Trauma

Sensors, 2013
The isolation of hematopoietic stem and progenitor cells (HSPCs) is critical for transplantation therapy and HSPC research, however current isolation techniques can be prohibitively expensive, time-consuming, and produce variable results. Selectin-coated
Michael R. King, Jane Liesveld, Thong M. Cao, Michael J. Mitchell   +3 more
doaj   +1 more source

Toll-Like Receptor induced CD11b and L-selectin response in patients with coronary artery disease. [PDF]

PLoS ONE, 2013
Toll-Like Receptor (TLR) -2 and -4 expression and TLR-induced cytokine response of inflammatory cells are related to atherogenesis and atherosclerotic plaque progression.
Ellen H A M Elsenberg, Marieke A Hillaert, Hester M den Ruijter, Jan-Willem E M Sels, Vincent P W Scholtes, Hendrik M Nathoe, Johan Kuiper, J Wouter Jukema, Pieter A Doevendans, Gerard Pasterkamp, Imo E Hoefer   +10 more
doaj   +1 more source

Elevated serum L-selectin levels and decreased L-selectin expression on CD8+ lymphocytes in systemic sclerosis [PDF]

Clinical and Experimental Immunology, 2001
SUMMARYL-selectin is expressed on most circulating leucocytes and mediates leucocyte rolling on endothelium at sites of inflammation. Following rolling or activation of leucocytes, cell surface L-selectin is released as soluble L-selectin (sL-selectin).
Y, Shimada, M, Hasegawa, K, Takehara, S, Sato   +3 more
openaire   +2 more sources

IL-8-induced L-selectin shedding regulates its binding kinetics to PSGL-1

, 2009
L-selectin plays a crucial role in inflammation cascade by initiating the tethering and rolling of leukocytes on endothelium wall. While many L-selectin molecules are rapidly shed from the cell surface upon activation, the remaining membrane-anchored L ...
贾潇凌, 龙勉, 陈娟
core   +1 more source