Results 31 to 40 of about 43,908 (154)

Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes

eLife, 2016
Myeloid-derived suppressor cells (MDSC) contribute to an immunosuppressive network that drives cancer escape by disabling T cell adaptive immunity. The prevailing view is that MDSC-mediated immunosuppression is restricted to tissues where MDSC co-mingle ...
Amy W Ku, Jason B Muhitch, Colin A Powers, Michael Diehl, Minhyung Kim, Daniel T Fisher, Anand P Sharda, Virginia K Clements, Kieran O'Loughlin, Hans Minderman, Michelle N Messmer, Jing Ma, Joseph J Skitzki, Douglas A Steeber, Bruce Walcheck, Suzanne Ostrand-Rosenberg, Scott I Abrams, Sharon S Evans   +17 more
doaj   +1 more source

Stem Cell Enrichment with Selectin Receptors: Mimicking the pH Environment of Trauma

Sensors, 2013
The isolation of hematopoietic stem and progenitor cells (HSPCs) is critical for transplantation therapy and HSPC research, however current isolation techniques can be prohibitively expensive, time-consuming, and produce variable results. Selectin-coated
Michael R. King, Jane Liesveld, Thong M. Cao, Michael J. Mitchell   +3 more
doaj   +1 more source

Toll-Like Receptor induced CD11b and L-selectin response in patients with coronary artery disease. [PDF]

PLoS ONE, 2013
Toll-Like Receptor (TLR) -2 and -4 expression and TLR-induced cytokine response of inflammatory cells are related to atherogenesis and atherosclerotic plaque progression.
Ellen H A M Elsenberg, Marieke A Hillaert, Hester M den Ruijter, Jan-Willem E M Sels, Vincent P W Scholtes, Hendrik M Nathoe, Johan Kuiper, J Wouter Jukema, Pieter A Doevendans, Gerard Pasterkamp, Imo E Hoefer   +10 more
doaj   +1 more source

Elevated serum L-selectin levels and decreased L-selectin expression on CD8+ lymphocytes in systemic sclerosis [PDF]

Clinical and Experimental Immunology, 2001
SUMMARYL-selectin is expressed on most circulating leucocytes and mediates leucocyte rolling on endothelium at sites of inflammation. Following rolling or activation of leucocytes, cell surface L-selectin is released as soluble L-selectin (sL-selectin).
Y, Shimada, M, Hasegawa, K, Takehara, S, Sato   +3 more
openaire   +2 more sources

P-selectin expression tracks cerebral atrophy in Mexican-Americans

Frontiers in Genetics, 2012
Background and Purpose. We hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure (BP) and cerebral atrophy.
Peter eKochunov, David eGlahn, Elliott eHong, Jack L Lancaster, Joanne eCurran, Matthew eJohnson, Anderson eWinkler, Henry eHolcomb, Jack eKent, Braxton eMitchell, Valeria eKochunov, Rene eOlvera, Shelley eCole, Thomas eDyer, Eric eMoses, Harald eGoring, Laura eAlmasy, Ravi eDuggirala, John eBlangero   +18 more
doaj   +1 more source

L-selectin — a signalling receptor for lipopolysaccharide

Chemistry & Biology, 1997
The activation of leukocytes by bacterial cell-wall lipopolysaccharide contributes to the pathogenesis of septic shock. We propose that in neutrophils, and possibly other leukocytes, L-selectin can act as a low-affinity lipopolysaccharide receptor.
Malhotra, Rajneesh, Bird, Michael I.
openaire   +2 more sources

Immunohistochemical localization of adhesion molecules (CD62 and CD18) in the mammary gland of dairy cows

Czech Journal of Animal Science, 2007
Localization of the L-selectin (CD62L) and β2-integrin (CD18) bearing cells in different tissues of the bovine mammary gland was examined. Five dairy cows of Holstein-Friesian breed in the middle of their second and third lactation cycle were used in the
M. Simon, S. Hluchý, Ľ. Horovská, J. Antalíková, J. Čuboň   +4 more
doaj   +1 more source

Lung-Derived Selectins Enhance Metastatic Behavior of Triple Negative Breast Cancer Cells

Biomedicines, 2021
The lung is one of the deadliest sites of breast cancer metastasis, particularly for triple negative breast cancer (TNBC). We have previously shown that the lung produces several soluble factors that may enhance the metastatic behavior of TNBC, including
Sami U. Khan, Ying Xia, David Goodale, Gabriella Schoettle, Alison L. Allan   +4 more
doaj   +1 more source

Adaptive Observer for Coupled Wave PDE and Infinite ODE With Sampled Data and Unknown Input: Application to Brain Hemodynamics Estimation

International Journal of Adaptive Control and Signal Processing, EarlyView.
This article proposes a convergent adaptive observer for a damped wave PDE and an infinite‐dimensional ODE coupled in cascade using sampled‐in‐space ODE state measurements. The proposed observer estimates the distributed states of the PDE and ODE along with unknown PDE parameters and spatial input.
Zehor Belkhatir, Sarah Mechhoud, Taous‐Meriem Laleg‐Kirati   +2 more
wiley   +1 more source

Neutrophil‐Mimetic MRI Enables Ultra‐Early Detection of Vascular Inflammation After Stroke

Advanced Healthcare Materials, EarlyView.
In this study, we developed neutrophil‐mimetic MRI probes that detect ultra‐early neuroinflammation following ischemic stroke by targeting E‐selectin. Within seconds of their injection, these microparticles mimic initial leukocyte adhesion to the activated cerebral endothelium.
Marion Isabelle Morvan, Damien Levard, Eloïse Lemarchand, Amal Boublay, Charly Helaine, Jolan Malherbe, Mikaël Naveau, Didier Goux, Igor Khalin, Ankita Talukdar, Cheun Pelleter, Charlène Jacqmarcq, Erwan Baudron, Isabelle Bardou, Sara Martinez de Lizarrondo, Maxime Gauberti, Denis Vivien, Antoine Philippe Fournier   +17 more
wiley   +1 more source