Results 1 to 10 of about 12,701 (240)
Selectins—The Two Dr. Jekyll and Mr. Hyde Faces of Adhesion Molecules—A Review
Molecules, 2020 Selectins belong to a group of adhesion molecules that fulfill an essential role in immune and inflammatory responses and tissue healing. Selectins are glycoproteins that decode the information carried by glycan structures, and non-covalent interactions ...
Jaroslav Koca +2 more
exaly +3 more sources
Interplay of integrins and selectins in metastasis [PDF]
Molecular OncologyMetastasis is a hallmark of malignancy and poses a formidable challenge for oncologists. This complex process begins when the primary malignant cells start to proliferate unlimitedly.
Diana Maltseva +2 more
doaj +2 more sources
Early in vitro results indicate that de-O-acetylated sialic acids increase Selectin binding in cancers [PDF]
Frontiers in OncologyCancers utilize a simple glycan, Sialic Acid, to engage in metastatic processes via the Sialic acid (Sia) -Selectin pathway. Selectins recognize and bind to sialylated substrates, resulting in adhesion, migration, and extravasation, however, how ...
Kakali Das +7 more
doaj +2 more sources
Targeting Selectins Mediated Biological Activities With Multivalent Probes
Frontiers in Chemistry, 2021 Selectins are type-I transmembrane glycoproteins that are ubiquitously expressed on activated platelets, endothelial cells, and leukocytes. They bind to cell surface glycoproteins and extracellular matrix ligands, regulate the rolling of leukocytes in ...
Prashant Jain +2 more
exaly +3 more sources
Dual implication of endothelial adhesion molecules in tumor progression and cancer immunity [PDF]
Cell Adhesion & MigrationAdhesion molecules are proteins expressed at the surface of various cell types. Their main contribution to immunity is to allow the infiltration of immune cells in an inflamed site.
Louis-Emmanuel Chriqui +2 more
doaj +2 more sources
Predictive value of plasma sICAM-1 and sP-Selectins in the risk of death in patients with acute respiratory distress syndrome [PDF]
Journal of Medical BiochemistryBackground: To evaluate the predictive value of sICAM-1 and sP-Selectins in the risk of death in a prospective cohort of adult acute respiratory distress syndrome (ARDS). Methods: Adult ARDS patients were included.
Jing Pan +4 more
doaj +2 more sources
Opportunities for the treatment of atherosclerosis: Selectins
Pharmacological ResearchDespite the widespread availability of selectins for tumor therapy, their contribution to atherosclerosis has long been under-emphasized due to their “cofactor’s” status and technological limitations.
Nai-Hong Chen, Ling Zhao, Yan Yang
exaly +3 more sources
Journal of Innate Immunity, 2021 Expression of the extensively glycosylated Ebolavirus glycoprotein (EBOV-GP) induces physical alterations of surface molecules and plays a crucial role in viral pathogenicity.
Mostafa Jarahian +11 more
doaj +1 more source
Lung-Derived Selectins Enhance Metastatic Behavior of Triple Negative Breast Cancer Cells
Biomedicines, 2021 The lung is one of the deadliest sites of breast cancer metastasis, particularly for triple negative breast cancer (TNBC). We have previously shown that the lung produces several soluble factors that may enhance the metastatic behavior of TNBC, including
Sami U. Khan +4 more
doaj +1 more source
Biomedicines, 2022 Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by thrombosis and/or obstetric complications in the presence of antiphospholipid antibodies (aPL).
Ula Štok +6 more
doaj +1 more source